Citra Tubuh Pada Remaja Putri Menikah Dan Memiliki Anak

Fenomena remaja putri yang menikah dan memiliki anak sudah lazim bagi masyarakat Indonesia. Remaja putri, dalam kaitannya dengan masa pertumbuhan masih tengah tumbuh untuk mencapai kematangan fisik dan mental. Namun, bagi remaja putri yang sudah menikah dan memiliki anak tengah dihadapkan pada keadaan yang berbeda. Remaja putri yang memiliki anak, mengalami keadaan yang umumnya terjadi pada perempuan dewasa, seperti tidak lagi perawan, mengandung, melahirkan anak, menyusui, dan mungkin naiknya berat badan pasca melahirkan. Keadaan tersebut memungkinkan terjadinya perbedaan sikap mental, terutama cara pandang remaja putri terhadap tubuhnya sendiri atau yang biasa disebut dengan citra tubuh. Penelitian ini bertujuan untuk menjelaskan gambaran citra tubuh dan faktor-faktor yang merupakan pembentukan citra tubuh pada remaja putri menikah yang memiliki anak. Penelitian menggunakan pendekatan kualitatif dengan bentuk studi kasus. Karakteristik subjek dalam penelitian ini adalah remaja putri berusia 20 tahun dan telah menikah dan memiliki seorang anak. Hasil penelitian menunjukkan gambaran citra tubuh yang positif pada subjek berdasarkan tiga (3) komponen yang dimiliki subjek. Subjek secara umum tepat mempersepsikan tubuhnya, memiliki sikap puas dan tidak memiliki kecemasan pada tubuhnya, serta tidak menghindari aktivitas yang menunjukkan bentuk tubuhnya. Faktor pembentukan citra tubuh pada subjek adalah siklus hidup, konsep diri, sosialisasi, peran gender, dan distorsi citra tubuh

Tingkat Kedisiplinan Mahasiswa dalam Proses Perkuliahan Jurusan Ilmu Keolahragaan Prodi Penjaskesrek Pontianak 2014

This research aims to determine the level of discipline of students in the lecture in particular disciplines seen from the attitude, honesty and responsibility of students majoring in sport science department of penjaskesrek FKIP UNTAN. The method used is descriptive method of research survey form. The population in this research were 186 students of odd semester. While the sample used is total sampling, amounting to 186 students of odd semester. Based on the results of research conducted on the level of discipline of students in the lecture in Prodi penjaskesrek FKIP UNTAN classified in three classifications are very good at 17.2%, good for 65.1% and 17.7% enough. These data indicate that the level of discipline penjaskesrek students in the lecture included in both categories is equal to 65.1%

Prevention of HIV Transmission Among Men Who Have Sex with Men and Compliance with Sexual Protective Equipment

Sexual orientations, such as gay, lesbian, and bisexual, are prevalent among individuals at high risk of experiencing mental health problems, including drug use, depression, emotional distress, and suicide. Therefore, this study aimed to assess the compliance of men who have sex with men with protective equipment and determine the dominant influential factors. This cross-sectional study included 187 men who had sexual intercourse with men who were recruited from two foundations based in Palembang City, Indonesia, focusing on people living with HIV/AIDS. Data were analyzed using Chi-square and binomial logistic regression. In this context, 50.8% of men who have sexual intercourse with men did not comply with the use of sexual protective equipment, exceeding those in compliance. The multivariate logistic regression showed that knowledge was the dominant factor (PR = 15.733; 95% CI = 4.063-60.920), and most low-knowledge individuals were 15.733 times more at risk of non-compliance. Intensive education is needed regarding the potential risk of transmission, considering the ease of access to condoms

EPIDEMIOLOGICAL ASPECTS OF HIV-TB CO-INFECTION IN PEOPLE WITH HIV/AIDS (PLWHA): A HOSPITAL-BASED STUDY

Introduction : Tuberculosis (TB) is one of the co-infections with high morbidity and mortality in patients with HIV/AIDS (PLWHA). The prevalence of Tuberculosis in HIV patients in Indonesia ranges from 19.7% to 61.5%. Aims: This study aimed to identify predictors of incident HIV-TB co-infection in PLWHA. Methods: This observational study used a case-control design. Cases were defined as patients with HIV/AIDS co-infected with TB, while controls were those with HIV/AIDS without TB co-infection. The study population included 180 PLWHA, comprising 60 cases and 120 controls. Exclusion criteria for the case group were patients who had not completed their medical records and those who were previously infected with TB before HIV infection. Results: Bivariate analysis showed that variables significantly related to TB-HIV were clinical stage, CD4 levels, anemia status, and opportunistic infections. Multivariate logistic regression analysis showed that CD4 levels were the dominant predictor, with an adjusted odds ratio (AOR) of 5.71, 95% confidence interval (CI) 2.84-11.84, p = 0.0001. Meanwhile, clinical stage, anemia status, and opportunistic infections were confounding variables. Conclusion: CD4 levels were found to be a dominant predictor of increased TB-HIV risk. Further efforts should be made to encourage home assistant care initiation and improve medication compliance based on these results

Genotype-dependent associations between serotonin transporter gene (SLC6A4) DNA methylation and late-life depression

International audienceBACKGROUND: Disrupted serotonergic signaling is often a feature of depression and the role of the serotonin transporter gene (SLC6A4), responsible for serotonin re-uptake, has received much attention in this regard. Most studies have focused on the polymorphic 5-HTTLPR upstream repeat, or DNA methylation at the promoter CpG island. Few studies have explored the influence of genetic variation across the gene on DNA methylation, and their combined association with depression risk. The aim of this study was to determine whether genetic variation in the SLC6A4 gene influences promoter DNA methylation, and whether these are associated with depression status.METHOD: The ESPRIT study involves a community-based population of older individuals (> 65 years of age). Major depressive disorder (MDD) was diagnosed according to DSM-IV (American Psychiatric Association, 1994) criteria, and severe depressive symptoms assessed by the Centre for Epidemiological Studies Depression (CES-D) Scale. Sequenom MassARRAY was used to measure SLC6A4 methylation status (n = 302).RESULTS: Nominally significant associations were observed between SLC6A4 genetic variants (5-HTTLPR, rs140700, rs4251417, rs6354, rs25528, rs25531) and DNA methylation at several CpG sites. In multivariate regression, DNA methylation was associated with depression status, but only in the presence of specific genotypes. In individuals homozygous for the short 5-HTTLPR and 5-HTTLPR/r25531 alleles, lower methylation at two CpGs was associated with depression (β = - 0.44 to β = - 0.31; p = 0.001 to p = 0.038).CONCLUSION: We present evidence for genotype-dependent associations between SLC6A4 methylation and depression. Genetic variants may also play a role in influencing promoter methylation levels and its association with depression

BDNF promoter methylation and genetic variation in late-life depression

AbstractThe regulation of the brain-derived neurotrophic factor (BDNF) is important for depression pathophysiology and epigenetic regulation of the BDNF gene may be involved. This study investigated whether BDNF methylation is a marker of depression. One thousand and twenty-four participants were recruited as part of a longitudinal study of psychiatric disorders in general population elderly (age⩾65). Clinical levels of depression were assessed using the Mini International Neuropsychiatric Interview for the diagnosis of major depressive disorder according to the Diagnostic and Statistical Manual of Mental Disorder IV criteria, and the Centre for Epidemiologic Studies Depression Scale (CES-D) for assessment of moderate to severe depressive symptoms. Buccal DNA methylation at the two most widely studied BDNF promoters, I and IV, was investigated using the Sequenom MassARRAY platform that allows high-throughput investigation of methylation at individual CpG sites within defined genomic regions. In multivariate linear regression analyses adjusted for a range of participant characteristics including antidepressant use, depression at baseline, as well as chronic late-life depression over the 12-year follow-up, were associated with overall higher BDNF methylation levels, with two sites showing significant associations (promoter I, Δ mean=0.4%, P=0.0002; promoter IV, Δ mean=5.4%, P=0.021). Three single-nucleotide polymorphisms (rs6265, rs7103411 and rs908867) were also found to modify the association between depression and promoter I methylation. As one of the largest epigenetic studies of depression, and the first investigating BDNF methylation in buccal tissue, our findings highlight the potential for buccal BDNF methylation to be a biomarker of depression.</jats:p