Edge-ICN and its application to the Internet of Things

While research on Information-Centric Networking (ICN) flourishes, its adoption seems to be an elusive goal. In this paper we propose Edge-ICN: a novel approach for deploying ICN in a single large network, such as the network of an Internet Service Provider. Although Edge-ICN requires nothing beyond an SDN-based network supporting the OpenFlow protocol, with ICN-aware nodes only at the edges of the network, it still offers the same benefits as a clean-slate ICN architecture but without the deployment hassles. Moreover, by proxying legacy traffic and transparently forwarding it through the Edge-ICN nodes, all existing applications can operate smoothly, while offering significant advantages to applications such as native support for scalable anycast, multicast, and multi-source forwarding. In this context, we show how the proposed functionality at the edge of the network can specifically benefit CoAP-based IoT applications. Our measurements show that Edge-ICN induces on average the same control plane overhead for name resolution as a centralized approach, while also enabling IoT applications to build on anycast, multicast, and multi-source forwarding primitives.Comment: IFIP Networking Workshops, IFIP, 201

The Global Longitudinal Study of Osteoporosis in Women (GLOW): rationale and study design

SUMMARY: The Global Longitudinal study of Osteoporosis in Women (GLOW) is a prospective cohort study involving 723 physicians and 60,393 women subjects >or=55 years. The data will provide insights into the management of fracture risk in older women over 5 years, patient experience with prevention and treatment, and distribution of risk among older women on an international basis. INTRODUCTION: Data from cohort studies describing the distribution of osteoporosis-related fractures and risk factors are not directly comparable and do not compare regional differences in patterns of patient management and fracture outcomes. METHODS: The GLOW is a prospective, multinational, observational cohort study. Practices typical of each region were identified through primary care networks organized for administrative, research, or educational purposes. Noninstitutionalized patients visiting each practice within the previous 2 years were eligible. Self-administered questionnaires were mailed, with 2:1 oversampling of women >or=65 years. Follow-up questionnaires will be sent at 12-month intervals for 5 years. RESULTS: A total of 723 physicians at 17 sites in ten countries agreed to participate. Baseline surveys were mailed (October 2006 to February 2008) to 140,416 subjects. After the exclusion of 3,265 women who were ineligible or had died, 60,393 agreed to participate. CONCLUSIONS: GLOW will provide contemporary information on patterns of management of fracture risk in older women over a 5-year period. The collection of data in a similar manner in ten countries will permit comparisons of patient experience with prevention and treatment and provide insights into the distribution of risk among older women on an international basis

Design and performance evaluation of a lightweight wireless early warning intrusion detection prototype

The proliferation of wireless networks has been remarkable during the last decade. The license-free nature of the ISM band along with the rapid proliferation of the Wi-Fi-enabled devices, especially the smart phones, has substantially increased the demand for broadband wireless access. However, due to their open nature, wireless networks are susceptible to a number of attacks. In this work, we present anomaly-based intrusion detection algorithms for the detection of three types of attacks: (i) attacks performed on the same channel legitimate clients use for communication, (ii) attacks on neighbouring channels, and (iii) severe attacks that completely block network's operation. Our detection algorithms are based on the cumulative sum change-point technique and they execute on a real lightweight prototype based on a limited resource mini-ITX node. The performance evaluation shows that even with limited hardware resources, the prototype can detect attacks with high detection rates and a few false alarms. © 2012 Fragkiadakis et al

Ubiquitous robust communications for emergency response using multi-operator heterogeneous networks

A number of disasters in various places of the planet have caused an extensive loss of lives, severe damages to properties and the environment, as well as a tremendous shock to the survivors. For relief and mitigation operations, emergency responders are immediately dispatched to the disaster areas. Ubiquitous and robust communications during the emergency response operations are of paramount importance. Nevertheless, various reports have highlighted that after many devastating events, the current technologies used, failed to support the mission critical communications, resulting in further loss of lives. Inefficiencies of the current communications used for emergency response include lack of technology inter-operability between different jurisdictions, and high vulnerability due to their centralized infrastructure. In this article, we propose a flexible network architecture that provides a common networking platform for heterogeneous multi-operator networks, for interoperation in case of emergencies. A wireless mesh network is the main part of the proposed architecture and this provides a back-up network in case of emergencies. We first describe the shortcomings and limitations of the current technologies, and then we address issues related to the applications and functionalities a future emergency response network should support. Furthermore, we describe the necessary requirements for a flexible, secure, robust, and QoS-aware emergency response multi-operator architecture, and then we suggest several schemes that can be adopted by our proposed architecture to meet those requirements. In addition, we suggest several methods for the re-tasking of communication means owned by independent individuals to provide support during emergencies. In order to investigate the feasibility of multimedia transmission over a wireless mesh network, we measured the performance of a video streaming application in a real wireless metropolitan multi-radio mesh network, showing that the mesh network can meet the requirements for high quality video transmissions

FRAX (R): Prediction of Major Osteoporotic Fractures in Women from the General Population: The OPUS Study

Purposes: The aim of this study was to analyse how well FRAXH predicts the risk of major osteoporotic and vertebral fractures over 6 years in postmenopausal women from general population. Patients and methods: The OPUS study was conducted in European women aged above 55 years, recruited in 5 centers from random population samples and followed over 6 years. The population for this study consisted of 1748 women (mean age 74.2 years) with information on incident fractures. 742 (43.1%) had a prevalent fracture; 769 (44%) and 155 (8.9%) of them received an antiosteoporotic treatment before and during the study respectively. We compared FRAXH performance with and without bone mineral density (BMD) using receiver operator characteristic (ROC) c-statistical analysis with ORs and areas under receiver operating characteristics curves (AUCs) and net reclassification improvement (NRI). Results: 85 (4.9%) patients had incident major fractures over 6 years. FRAXH with and without BMD predicted these fractures with an AUC of 0.66 and 0.62 respectively. The AUC were 0.60, 0.66, 0.69 for history of low trauma fracture alone, age and femoral neck (FN) BMD and combination of the 3 clinical risk factors, respectively. FRAXH with and without BMD predicted incident radiographic vertebral fracture (n = 65) with an AUC of 0.67 and 0.65 respectively. NRI analysis showed a significant improvement in risk assignment when BMD is added to FRAXH. Conclusions: This study shows that FRAXH with BMD and to a lesser extent also without FN BMD predict major osteoporotic and vertebral fractures in the general population

Anatomía de la pared torácica : Implicancia para la realización de las toracotomías laterales

El objetivo del trabajo se basa en la descripción detallada de la anatomía de los músculos ánterolaterales del tórax, sus pedículos vásculonerviosos y la importancia que implica en el abordaje quirúrgico del tórax. Se procede a la disección de 8 preparados formalizados de ambos sexos en los cuales se realiza una disección minuciosa de los músculos ánterolaterales de la pared torácica y de sus pedículos vásculonerviosos. Se procedió posteriormente a realizar la movilización del músculo dorsal ancho y la disección del pedículo del músculo serrato mayor.Facultad de Ciencias Médica

Anatomía de la pared torácica : Implicancia para la realización de las toracotomías laterales

El objetivo del trabajo se basa en la descripción detallada de la anatomía de los músculos ánterolaterales del tórax, sus pedículos vásculonerviosos y la importancia que implica en el abordaje quirúrgico del tórax. Se procede a la disección de 8 preparados formalizados de ambos sexos en los cuales se realiza una disección minuciosa de los músculos ánterolaterales de la pared torácica y de sus pedículos vásculonerviosos. Se procedió posteriormente a realizar la movilización del músculo dorsal ancho y la disección del pedículo del músculo serrato mayor.Facultad de Ciencias Médica

Compliance and persistence with osteoporosis medications: A critical review of the literature

It is widely acknowledged that compliance and persistence with oral osteoporosis medications, particularly with bisphosphonates, is poor. Several excellent reviews have been written on compliance and persistence with osteoporosis medications and have discussed improvements seen with extended dosing intervals. This review begins with studies on extended dosing intervals to examine the limitations of administrative claims data. It also looks at compliance and persistence across multiple medical conditions, examining the importance of prescription fulfillment, intentional choice, causation and possible interventions

Adherence and profile of non-persistence in patients treated for osteoporosis—a large-scale, long-term retrospective study in The Netherlands

We analyzed 12-month compliance for all ten oral osteoporosis drugs in the Netherlands by medication possession ratio (MPR a parts per thousand yenaEuro parts per thousand 80%) in 105,506 patients, and persistence in 8,626 starters indicated high MPR (91%), low persistence (43%), and no restart in 78% of the stoppers after 18 months. We studied compliance and persistence for all available oral osteoporosis medications on a national scale in the Netherlands. We analyzed the IMS Health's longitudinal prescription database, which represents 73% of all pharmacies in the Netherlands. Twelve-month compliance was measured by medication possession ratio (MPR) in a cross-sectional cohort of 105,506 patients who received at least three prescriptions. Twelve-month persistence (no gap in refills for > 6 months) was measured in all 8,626 consecutive patients starting therapy, with a further follow-up in non-persistent patients during an additional 18 months for evaluation of switching, restart, or definitive stopping oral medication. Multivariate logistic regression analysis was used to analyze the odds ratios (ORs) with 95% confidence intervals (CI) of characteristics of non-persistence. MPR of a parts per thousand yen80% was found in 91% of patients. Persistence was 43% (range, 29-52%). Persistence was related to age > 60 years (ORs, 1.41 to 1.64), pharmacy outside very dense urban area (ORs, 1.39 to 1.44), additional use of calcium and/or vitamin D supplementation (OR, 1.26 and CI, 1.13, 1.39) and use of glucocorticoids (OR, 0.65 and CI, 0.59, 0.72) or cardiovascular medication (OR, 0.88 and CI, 0.79, 0.97). Of non-persistent patients, 22% restarted within 18 months with oral osteoporosis drugs. One-year compliance for all available oral osteoporosis medications was high, but 1-year persistence was low. Most stoppers did not restart or switch during an additional 18-month follow-up. These data indicate a major failure to adequately treat patients at high risk for fractures in daily practice.Amgen provided funds to IMS for data analysis. The preparation of this article was not supported by external funding. J.C. Netelenbos and P.P. Geusens have no conflict of interest, including specific financial interest and relationships and affiliations relevant to the subject matter or materials discussed in the manuscript. Buijs and Ypma are employees of IMS Health

Using clinical risk factors and bone mineral density to determine who among patients undergoing bone densitometry should have vertebral fracture assessment

Vertebral fracture assessment (VFA) is a new method for imaging thoracolumbar spine on bone densitometer. Among patients referred for bone densitometry, the selection of patients for VFA testing can be optimized using an index derived from clinical risk factors and bone density measurement. VFA, a method for imaging thoracolumbar spine on bone densitometer, was developed because vertebral fractures, although common and predictive of future fractures, are often not clinically diagnosed. The study objective was to develop a strategy for selecting patients for VFA. A convenience sample from a university hospital bone densitometry center included 892 subjects (795 women) referred for bone mineral density (BMD) testing. We used questionnaires to capture clinical risk factors and dual-energy X-ray absorptiometry to obtain BMD and VFA. Prevalence of vertebral fractures was 18% in women and 31% in men (p = 0.003 for gender difference). In women, age, height loss, glucocorticoid use, history of vertebral and other fractures, and BMD T-score were significantly and independently associated with vertebral fractures. A multivariate model which included above predictors had an area under the receiver operating curve of 0.85 with 95% confidence interval (CI) of 0.81 to 0.89. A risk factor index was derived from the above multivariate model. Using a level of 2 as a cut-off yielded 93% sensitivity (95% CI 87, 96) and 48% specificity (95% CI 69, 83). Assuming a 15% prevalence of vertebral fractures, this cut-off value had a 24% positive and 97% negative predictive value and required VFA scanning of three women at a cost of $60 (assuming a$20 cost/VFA scan) to detect one with vertebral fracture(s). Selecting patients for VFA can be optimized using an index derived from BMD measurement and easily obtained clinical risk factors