Changing Role of Teachers in the Present Society

The young today are facing the world in which communication and information revolution has led to changes in all spheres: scientific, technological, political, economic, social, and cultural. To be able to prepare our young people to face the future with confidence purpose and responsibility, the crucial role of teachers cannot be overemphasized. Given these multidimensional demands, Role of teachers also has to change. In the past, teachers used to be a major source of knowledge, the leader, and educator of their students school life. The changes that took place in education have initiated to change the role of teachers. In this article, we will examine how the role of teachers in the present society has to change

CyanoPhyChe: A Database for Physico-Chemical Properties, Structure and Biochemical Pathway Information of Cyanobacterial Proteins

CyanoPhyChe is a user friendly database that one can browse through for physico-chemical properties, structure and biochemical pathway information of cyanobacterial proteins. We downloaded all the protein sequences from the cyanobacterial genome database for calculating the physico-chemical properties, such as molecular weight, net charge of protein, isoelectric point, molar extinction coefficient, canonical variable for solubility, grand average hydropathy, aliphatic index, and number of charged residues. Based on the physico-chemical properties, we provide the polarity, structural stability and probability of a protein entering in to an inclusion body (PEPIB). We used the data generated on physico-chemical properties, structure and biochemical pathway information of all cyanobacterial proteins to construct CyanoPhyChe. The data can be used for optimizing methods of expression and characterization of cyanobacterial proteins. Moreover, the ‘Search’ and data export options provided will be useful for proteome analysis. Secondary structure was predicted for all the cyanobacterial proteins using PSIPRED tool and the data generated is made accessible to researchers working on cyanobacteria. In addition, external links are provided to biological databases such as PDB and KEGG for molecular structure and biochemical pathway information, respectively. External links are also provided to different cyanobacterial databases. CyanoPhyChe can be accessed from the following URL: http://bif.uohyd.ac.in/cpc

Attributes and Implications of Gender Discriminations in Women’s Education in a Rural Area of Coimbatore, Tamil Nadu: the Findings of Focus Group Discussions

India is a fast-growing economy and the scientific and technical advancements in the county have tremendously improved. But when we look at the state of women in our country, we are very backward and women are subjected to severe gender discriminations. This is evident from our falling sex ratio, gender gap in education, employment, health status and the high rates of violence against women. There are many reasons for this unfortunate status of women in our country. Our social norms, cultural beliefs and the patriarchal mindset have made women vulnerable and deprived of freedom and wellbeing

Fibrodysplasia ossificans progressiva: a comprehensive review

Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder that causes heterotopic ossification of soft tissues, leading to abnormal bone growth in muscles, tendons, and ligaments. First identified in the 17th century, FOP was classified in 1968 and is linked to a mutation in the Activin A receptor type I gene (ACVR1) which affects bone morphogenetic protein (BMP). The autosomal dominant condition FOP has the potential to lead to aberrant bone development. At birth, FOP individuals appear normal, except for characteristic malformations of the great toes. FOP patients develop painful, inflammatory soft tissue swellings during the first decade of life, often precipitated by soft tissue injury. Minor trauma can trigger new flare-ups and leads to progressive heterotopic ossification. Most FOP sufferers are wheelchair-bound by their third decade and needs lifelong assistance with daily living tasks. Bone morphogenetic proteins (BMPs) are bound by the transmembrane kinase receptor ALK2, which is encoded by the (ACVR1/ALK2 gene). FOPs induce heterotopic bone formation in skeletal muscle and can be caused by mutations in the activin A receptor type I (ACVR1) and activin-like kinase 2 (ALK2) gene. Clinical therapy focuses on preventing and controlling inflammation, with ongoing research focusing on specific therapies targeting receptor activity, aberrant pathways, or cellular components influencing bone neo-formation

Abnormal uterine bleeding in perimenopausal age group women: a study on clinicopathological evaluation and management

Background: Abnormal uterine bleeding is the most common and frequent presenting complaint in Gynaecology Outpatient Department in all age groups, especially in perimenopausal women. Objective of present study was clinicopathological evaluation and management of abnormal uterine bleeding in perimenopausal age group women.Methods: The present study was prospective analytical study conducted at Mallareddy Narayana Multi-speciality Hospital, reputed teaching hospital, in Obstetrics and gynaecology department in association with department of pathology from January 2015 to December 2016. Perimenopausal women in age group 45-55 years included in this study. Other age groups with abnormal uterine bleeding, isolated cervical or vaginal pathology, bleeding diathesis, and pregnancy related causes of bleeding excluded from this study. Endometrial tissue collected by sampling procedure such as dilatation and curettage. Proper counselling about management was given to all women related to medical and surgical interventional approaches.Results: A total of 135 women with abnormal uterine bleeding in perimenopausal age were examined after fulfilling criteria during study period of 2 years. The age of participants in mean±SD was 46.68±2.03 years (min 45 years and max 55 years). Maximum number of patients with abnormal uterine bleeding presented in age group of 45-50 years. The most common symptoms were heavy menstrual bleeding (83.7%), followed by frequent menstrual bleeding (26.6%). Proliferative endometrium was the most common histopathological (30.3%) study followed by secretory endometrium (27.4%). Surgical management was given to 94 patients.Conclusions: Heavy menstrual bleeding and frequent menstrual bleeding were mostly correlated with abnormal endometrial histopathological findings in this study. Gynaecologists should pay attention towards these abnormal bleeding patterns along with the evaluation of endometrial tissue for histopathological findings, which will help us to plan for successful management.

A trustable real estate transaction based on public blockchain: a smart contract-driven framework

Introduction: the authorities responsible for Land Registration (LR) are often held accountable for the mishandling and forgery of LR documents in many countries. Some individuals may use a cutting-edge technology called Blockchain (BC) to digitally transfer assets such as currency, paperwork, and real estate (RE). Each transaction, monetary exchange, and shared information facilitated by a Peer-to-peer network (P2P) can be carried out through a designated node. Methods: this paper proposes a method for secure transfer of land ownership using BC Technology without the involvement of intermediaries. Buyers and sellers are entering into a land ownership agreement via the Ethereum network. The decentralised systems has been to enhance their reliability. Currently, there is a growing development of decentralised solutions based on blockchain technology to tackle the limitations of centralised systems. Results: the application of BC technology gradually mitigates the security concerns of the LR system. Due to the fact that each block is connected to the hash of the preceding one, each hash value will be unique. The SHA algorithm is employed for this purpose. Conclusion: the ownership of the property cannot be transferred to the customer through the application. However, the smart contracts allow for automated updating of record

Genotype dependent variation in native and inoculated soil microorganisms of FCV tobacco (Nicotiana tabacum) rhizosphere in vertisols and alfisols

Present study conducted during 2008-09 addresses the acquisition of nutrients from soil by tobacco (Nicotiana tabacum L.) plants with specific emphasis on the genotype and soil type with reference to structural and functional characteristics of roots that influence the availability and uptake of P and N. Objective is to explore the impact of tobacco genotypes VT-1158 and Siri in vertisols whereas 16/108, and Kanchan in alfisols on the activity of beneficial microorganisms such as Azotobacter, Azospirillum and Pseudomonas along with native microflora of the rhizosphere. After 45 DAT, the bacterial population was highest in number and it ranged from 7.02 to 10.90 in tobacco rhizosphere of vertisols and alfisols, while fungi were lowest in number which ranged from 3.92 × 103 to 5.30 × 103 cfu/g soil in the rhizosphere soil of vertisols var VT-1158 and Siri respectively. At 90 DAT microbial population declined in vertisols and alfisols of all the varieties. Inoculation of Azospirillum and Pseudomonas along with application of RDF resulted in maximum viable cell number of 5.89 × 106 cfu/g and 5.90 × 106 cfu/g soil in case of vertisols rhizoshpere of var VT-1158, while 5.95 × 106 cfu/ g and 6.47 × 106 cfu/g soil in the rhizosphere of alfisols tobacco respectively after 45 DAT. Inoculation of bacteria either as monoculture or mixed biofertilizer resulted in almost 10-30 times increase in microbial population of the inoculated bacteria; however, their population decreased after 90 DAT. Mixed biofertilizer (Azotobacter, Azospirillum and Pseudomonas) had a prolonged effect on plant parameters tested and showed a higher nutrient (N and P) content

“A Systematic Review on Clinical Characteristics and Co Morbidities of Covid 19 Patients”

Rationale of the study: Novel corona virus disease outbreak occurred in 2019 presenting as a respiratory illness. This infection spread to the whole world and caused significant mortality and morbidity. Clinical presentation and complications of COVID 19 are still obscure which needs to be explored. Aim of the study: This article aims at exploring the role and contributions of comorbidities in patients with COVID 19 infection. Materials and methods: A meta-analysis from 12 published articles obtained from electronic literature search was performed using PubMed, Scopus, Web of Science, google scholar and MedLine Plus. Full text articles published from 2020-2022 which were written in English were selected. Results: In this meta-analysis the total sample size was 7708, of which the median age of presentation was 57yrs. There was a predominance of males with the M:F ratio being 1.2:1. The most common symptom noted was fever (75.18%) and loss of smell (74.90%), the least common symptom was vomiting (4.76%). The most common co morbidity seen associated with Covid 19 patients was hypertension (34.54%) and diabetes (20.99%) and the least common was malignancy (2.02%) and the p value noted was >0.05. Conclusion: Covid 19 infection presents with acute respiratory distress syndrome and its clinical progression and prognosis is impacted by the presence of comorbidities especially hypertension and diabetes. This may help in proper identification of patients in risk category and prompt to take necessary precautions while treating the patients.

GREEN SYNTHESIS OF NANOSTRUCTURED ZINC PARTICLES USING AQUEOUS LEAF EXTRACT OF SCHREBERA SWIETENIOIDES ROXB. AND THEIR CATALYTIC APPLICATION IN DEGRADATION OF METHYL ORANGE, CRYSTAL VIOLET DYES AND CHROMIUM METAL

Objective: The present work was aimed to synthesized the zinc nanoparticles (ZnO NPs) using aqueous leaf extract of Schrebera swietenioides Roxb., and further, the green-synthesized ZnO NPs were studied for its efficacy in the degradation of hazardous dyes like methyl orange, crystal violet and hazardous metal such as chromium. Methods: The ZnO NPs were synthesized using aqueous leaf extract of S. swietenioides Roxb., as a green reducing agent and 0.1 M Zinc acetate as metal source and the NPs synthesis was completed within a short period of 6 h. The ZnO NPs synthesized were characterized using SEM, TEM, EDS, XRD, FT-IR and UV-visible spectrophotometer. Further, the synthesized NPs were applied for reduction of pollutant days such as methyl orange, crystal violet and pollutant metal chromium. Results: The synthesis of NPs was monitored by observing the color change in the reaction mixture and UV visible spectral analysis. The UV spectral analysis shows a characteristic absorption wavelength at 379 nm. The synthesized NPs were hexagonal wurtzite form crystals having a spherical shape with rough surfaces with an average size of 68 nm and having 73.7 % of zinc content. At a NPs dose of 1.0 g/l the photocatalytic reduction was observed as 85.33±0.02 %, 86.82±0.095 % and 86.73±0.104 % for crystal violet dye, methyl orange dye and chromium metal, respectively. The NPs shows a high % photocatalytic reduction of chromium metal, crystal violet dye and methyl orange dye with less contact time confirms that the synthesized ZnO NPs were effectively catalyzed the degradation of methyl orange, crystal violet dyes and chromium metal. The NPs were observed to be recyclable and can shows high reduction activity after the completion of three cycles of degradation. Conclusion: Hence it can be concluded that synthesized greener nanocatalyst was efficient for pollutant treatment and demonstrated the power of green biosynthesis for metallic nanoparticles