Is demagnetization an efficient optimization method?

Demagnetization, commonly employed to study ferromagnets, has been proposed as the basis for an optimization tool, a method to find the ground state of a disordered system. Here we present a detailed comparison between the ground state and the demagnetized state in the random field Ising model, combing exact results in $d=1$ and numerical solutions in $d=3$. We show that there are important differences between the two states that persist in the thermodynamic limit and thus conclude that AC demagnetization is not an efficient optimization method.Comment: 2 pages, 1 figur

Life Products of Stars

We attempt to document complete energetic transactions of stars in their life. We calculate photon and neutrino energies that are produced from stars in their each phase of evolution from 1 to 8 M_sun, using the state-of-the-art stellar evolution code, tracing the evolution continuously from pre-main sequence gravitational contraction to white dwarfs. We also catalogue gravitational and thermal energies and helium, and heavier elements that are stored in stars and those ejected into interstellar space in each evolutionary phase.Comment: 26 pages, including 8 figures and 3 tables. Submitted to ApJ

Preliminary definitions for the sonographic features of synovitis in children

Objectives Musculoskeletal ultrasonography (US) has the potential to be an important tool in the assessment of disease activity in childhood arthritides. To assess pathology, clear definitions for synovitis need to be developed first. The aim of this study was to develop and validate these definitions through an international consensus process. Methods The decision on which US techniques to use, the components to be included in the definitions as well as the final wording were developed by 31 ultrasound experts in a consensus process. A Likert scale of 1-5 with 1 indicating complete disagreement and 5 complete agreement was used. A minimum of 80% of the experts scoring 4 or 5 was required for final approval. The definitions were then validated on 120 standardized US images of the wrist, MCP and tibiotalar joints displaying various degrees of synovitis at various ages. Results B-Mode and Doppler should be used for assessing synovitis in children. A US definition of the various components (i.e. synovial hypertrophy, effusion and Doppler signal within the synovium) was developed. The definition was validated on still images with a median of 89% (range 80-100) of participants scoring it as 4 or 5 on a Likert scale. Conclusions US definitions of synovitis and its elementary components covering the entire pediatric age range were successfully developed through a Delphi process and validated in a web-based still images exercise. These results provide the basis for the standardized US assessment of synovitis in clinical practice and research

Mean Curvature Flow on Ricci Solitons

We study monotonic quantities in the context of combined geometric flows. In particular, focusing on Ricci solitons as the ambient space, we consider solutions of the heat type equation integrated over embedded submanifolds evolving by mean curvature flow and we study their monotonicity properties. This is part of an ongoing project with Magni and Mantegazzawhich will treat the case of non-solitonic backgrounds \cite{a_14}.Comment: 19 page

Clinical use of polymerase chain reaction performed on peripheral blood and bone marrow samples for the diagnosis and monitoring of visceral leishmaniasis in HIV-infected and HIV-uninfected patients: a single-center, 8-year experience in Italy and review of the literature

Background. To overcome some of the limitations of conventional microbiologic techniques, polymerase chain reaction (PCR)–based assays are proposed as useful tools for the diagnosis of visceral leishmaniasis. Patients and methods. A comparative study using conventional microbiologic techniques (i.e., serologic testing, microscopic examination, and culture) and a Leishmania species–specific PCR assay, using peripheral blood and bone marrow aspirate samples as templates, was conducted during an 8-year period. The study cohort consisted of 594 Italian immunocompetent (adult and pediatric) and immunocompromised (adult) patients experiencing febrile syndromes associated with hematologic alterations and/or hepatosplenomegaly. Identification of the infecting protozoa at the species level was directly obtained by PCR of peripheral blood samples, followed by restriction fragment–length polymorphism analysis of the amplified products, and the results were compared with those of isoenzyme typing of Leishmania species strains from patients, which were isolated in vitro. Results. Sixty-eight patients (11.4%) had a confirmed diagnosis of visceral leishmaniasis. Eleven cases were observed in human immunodeficiency virus (HIV)–uninfected adults, 20 cases were observed in HIV-infected adults, and the remaining 37 cases were diagnosed in HIV-uninfected children. In the diagnosis of primary visceral leishmaniasis, the sensitivities of the Leishmania species–specific PCR were 95.7% for bone marrow aspirate samples and 98.5% for peripheral blood samples versus sensitivities of 76.2%, 85.5%, and 90.2% for bone marrow aspirate isolation, serologic testing, and microscopic examination of bone marrow biopsy specimens, respectively. None of 229 healthy blood donors or 25 patients with imported malaria who were used as negative control subjects had PCR results positive for Leishmania species in peripheral blood samples (i.e., specificity of Leishmania species– specific PCR, 100%). PCR and restriction fragment–length polymorphism analysis for Leishmania species identification revealed 100% concordance with isoenzyme typing in the 19 patients for whom the latter data were available. Conclusions. PCR assay is a highly sensitive and specific tool for the diagnosis of visceral leishmaniasis in both immunocompetent and immunocompromised patients and can be reliably used for rapid parasite identification at the species level

GEANT4 : a simulation toolkit

Abstract Geant4 is a toolkit for simulating the passage of particles through matter. It includes a complete range of functionality including tracking, geometry, physics models and hits. The physics processes offered cover a comprehensive range, including electromagnetic, hadronic and optical processes, a large set of long-lived particles, materials and elements, over a wide energy range starting, in some cases, from 250 eV and extending in others to the TeV energy range. It has been designed and constructed to expose the physics models utilised, to handle complex geometries, and to enable its easy adaptation for optimal use in different sets of applications. The toolkit is the result of a worldwide collaboration of physicists and software engineers. It has been created exploiting software engineering and object-oriented technology and implemented in the C++ programming language. It has been used in applications in particle physics, nuclear physics, accelerator design, space engineering and medical physics. PACS: 07.05.Tp; 13; 2

The effects of reiterated cell photo-stimulation with an azobenzene

Optical stimulation of living cells is an innovative and successful tool, having a significant impact on neuroscience. A recently synthesized amphiphilic azobenzene, named Ziapin2, has been developed exploiting a non-covalent approach for targeting the membrane and achieving cell photostimulation. Here, we investigate, using both experimental data and mathematical modelling, the effect of repetitive light stimulation on the cell response. We discuss some possible explanations for the drop in the stimulation efficiency in reiterated stimulation processes

The Term Structure of Capital Values: An accounting-based framework for measuring economic profitability

This paper shows how the outputs of the accounting measurement process can be translated into terms that can be used in economic decisions. We introduce the notion of Term Structure of Capital Values (TSCV), uniquely associated to a Term Structure of Interest Rates (TSIR). We show that the state of temporary disequilibrium created by an asset (project, firm, etc.) introduced in a market can be described in terms of a pair of internal TSCV and TSIR. Any internal TSCV determines a specific depreciation schedule for the asset and the corresponding TSIR determines an economic rate of return obtained as a capital-weighted average of the Return On Assets collected in the TSIR. The difference between this economic rate of return and the overall equilibrium rate (itself an average of the equilibrium forward rates) correctly captures value creation. The determination of a specific (internal) TSCV depends on the way the market sweeps away arbitrage opportunities and restores the equilibrium. As each possible accounting system can be viewed as being associated with a corresponding disequilibrium-to-equilibrium process and therefore with a corresponding economic rate of return, the paper shows that the determination of an economic rate of return is both a matter of accounting (in terms of a specific internal TSCV) and a matter of finance (in terms of a specific disequilibrium-to-equilibrium process). This evidently calls for a theory of capital valuation capable of associating the proper TSCV with each asset so that the intrinsic underdetermination of the economic rate of return can be solve

Functional Integration Approach to Hysteresis

A general formulation of scalar hysteresis is proposed. This formulation is based on two steps. First, a generating function g(x) is associated with an individual system, and a hysteresis evolution operator is defined by an appropriate envelope construction applied to g(x), inspired by the overdamped dynamics of systems evolving in multistable free energy landscapes. Second, the average hysteresis response of an ensemble of such systems is expressed as a functional integral over the space G of all admissible generating functions, under the assumption that an appropriate measure m has been introduced in G. The consequences of the formulation are analyzed in detail in the case where the measure m is generated by a continuous, Markovian stochastic process. The calculation of the hysteresis properties of the ensemble is reduced to the solution of the level-crossing problem for the stochastic process. In particular, it is shown that, when the process is translationally invariant (homogeneous), the ensuing hysteresis properties can be exactly described by the Preisach model of hysteresis, and the associated Preisach distribution is expressed in closed analytic form in terms of the drift and diffusion parameters of the Markovian process. Possible applications of the formulation are suggested, concerning the interpretation of magnetic hysteresis due to domain wall motion in quenched-in disorder, and the interpretation of critical state models of superconducting hysteresis.Comment: 36 pages, 9 figures, to be published on Phys. Rev.