New metabolically stable fatty acid amide ligands of cannabinoid receptors: synthesis and receptor affinity studies

We investigated the structure-activity relationships for the interactions of fatty acid amide analogs of the endocannabinoid anandamide with human recombinant cannabinoid receptors. Thirty-five novel fatty acid amides were synthesized using five different types of acyl chains and 11 different aromatic amine 'heads.' Although none of the new compounds was a more potent ligand than anandamide, we identified three amine groups capable of improving the metabolic stability of arachidonoylamides and their CBI/CB2 selectivity ratio to over 20-fold, and several aromatic amines capable of improving the affinity of short chain or monosaturated fatty acids for cannabinoid CBI receptors. For the first time a tertiary amide of arachidonic acid was found to possess moderate affinity (K, = 300 nM) for cannabinoid CBI, but not CB2, receptors

The Alpha Magnetic Spectrometer (AMS) on the international space station: Part II — Results from the first seven years

The Alpha Magnetic Spectrometer (AMS) is a precision particle physics detector on the International Space Station (ISS) conducting a unique, long-duration mission of fundamental physics research in space. The physics objectives include the precise studies of the origin of dark matter, antimatter, and cosmic rays as well as the exploration of new phenomena. Following a 16-year period of construction and testing, and a precursor flight on the Space Shuttle, AMS was installed on the ISS on May 19, 2011. In this report we present results based on 120 billion charged cosmic ray events up to multi-TeV energies. This includes the fluxes of positrons, electrons, antiprotons, protons, and nuclei. These results provide unexpected information, which cannot be explained by the current theoretical models. The accuracy and characteristics of the data, simultaneously from many different types of cosmic rays, provide unique input to the understanding of origins, acceleration, and propagation of cosmic rays.</p

Analisi delle fallanze nella rete di distribuzione idrica della città di Ferrara

Viene effettuata l'analisi di fallanza della rete idrica di Ferrar

A Nonquasi-Static Empirical Model of Electron Devices

A new nonquasi-static nonlinear model of electron devices is proposed by adopting a perturbed charge-controlled approach. The model is based on the definition of a virtual quasi-static device, associated with the actual one, which is controlled by means of equivalent voltage sources. The advantage of this approach is that conventional purely quasi-static models can be still adopted even at very high frequencies, if suitable equivalent voltages are applied. Identification from small-signal measurements and implementation into commercially available computer-aided design tools of the new nonquasi-static model are described in this paper. Finally, by considering a GaAs p-high electron mobility transistor, accurate prediction capabilities at microwaves and millimeter frequencies are experimental verified and compared with a more conventional equivalent-circuit-based mode

Ductile cast irons: microstructure influence on fatigue crack propagation resistance

Microsctructure influence on fatigue crack propagation resistance in five different ductile cast irons was investigated.Four ferrite/pearlite volume fractions were considered

Fatigue crack micromechanisms on a PE Zn-Cu-Al alloy

Some Cu-Zn-Al alloy is able to exhibit an important feature: the Pseudo-Elastic behavior, commonly defined as PE alloy. The PE effect is the result of a non-diffusion microstructure changing characterized by a good reversibility at environmental temperature. Furthermore, the copper-based shape memory alloys are preferred for their good memory properties and low cost of production. In this work, fatigue crack propagation and microstructural fracture micromechanisms are analyzed in order to identify microstructure influence on fatigue behavior of Cu-Zn-Al PE alloy