21,653 research outputs found

    Energy landscapes and urban trajectories towards sustainability

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    An urban energy transition is needed to address the two global environmental challenges of urbanisation and increasing carbon emissions. Urban energy landscapes represent the spatial patterns of urban energy systems which are visible in the built environment. Spatial regularities in the way systems of energy provision and use are organised are manifest in urban energy landscapes. Energy uses may vary in relation to the structures of the built environment, and the perceptions that coevolve with technologies.This paper presents evidence from three case studies of urban energy landscapes in Hong Kong (PRC), Bengaluru (India) and Maputo (Mozambique). The cases suggest a variety of patterns (uniform, fragmented, scattered) in terms of how different fuels and electricity are provided and who has access to them. Qualitative research among policy makers reveals different trajectories towards sustainability. The paper concludes with the suggestion that the spatial organisation of urban energy systems shapes potential trajectories of change for an urban energy transition. This would call for forms of spatial planning that promote flexibility as a means to foster sustainability innovations. However, further evidence will be required to evaluate whether this exploratory analysis can be generalised beyond the three cities studied

    Modeling the role of oxygen vacancy on ferroelectric properties in thin films

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    2002-2003 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

    Network conduciveness with application to the graph-coloring and independent-set optimization transitions

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    We introduce the notion of a network's conduciveness, a probabilistically interpretable measure of how the network's structure allows it to be conducive to roaming agents, in certain conditions, from one portion of the network to another. We exemplify its use through an application to the two problems in combinatorial optimization that, given an undirected graph, ask that its so-called chromatic and independence numbers be found. Though NP-hard, when solved on sequences of expanding random graphs there appear marked transitions at which optimal solutions can be obtained substantially more easily than right before them. We demonstrate that these phenomena can be understood by resorting to the network that represents the solution space of the problems for each graph and examining its conduciveness between the non-optimal solutions and the optimal ones. At the said transitions, this network becomes strikingly more conducive in the direction of the optimal solutions than it was just before them, while at the same time becoming less conducive in the opposite direction. We believe that, besides becoming useful also in other areas in which network theory has a role to play, network conduciveness may become instrumental in helping clarify further issues related to NP-hardness that remain poorly understood

    Future Educators’ Gender Norms, Sexuality, and Reproductive Health.

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    This investigation explored gender-related norms, sexuality, and reproductive health among education students in a government university in Samar, Philippines. A descriptive-analytical design of study was adopted for this investigation and data were collected over a period of five months. Five hundred fifty (550) education students who were enrolled in the different year level completed the modified John Clelands’ Illustrative Questionnaire for Young People. Results indicated that 14.73% of the students reported having had early sexual experience where in 69.14 % had it unplanned. Among sexually active students, only 17.28% used contraception, with condoms and withdrawal as the most popular choices. Respondents were also found to have some misconceptions regarding HIV/AIDS and STI’s. Result also showed that dating was still acceptable, however, the idea of abortion and sexual coercion were considered wrong. No significant differences in the knowledge about HIV/AIDS and STI’s and gender norms were found across year level. Findings suggest a greater need for education, support and advocacy relative to sexuality so as to create a more positive school environment conducive for holistic growth and development of all students. Thus, school administrators should improve/enhance existing policies and programs relative to reproductive health among college students of the University such as health promotion activities, sexuality education, counseling and alike

    Methylation of CpG island is not a ubiquitous mechanism for the loss of oestrogen receptor in breast cancer cells.

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    Methylation has been shown to play an important role in the down-regulation of oestrogen receptors (ER) in breast cancer cells. One critical question that remains unclear is whether methylation can account for the loss of ER expression in cells derived from an ER-positive cell line. This laboratory has established an in vitro cell system using long-term growth of human ER-positive breast cancer cell line T47D in oestrogen-free medium. A clonal cell line, T47D:C4:2 (C4:2), has been characterized. Unlike T47D:A18 (A18), which is a T47D line maintained in oestrogen medium, C4:2 has lost the expression of ER and hormone responsiveness. DNA fingerprinting and restriction fragment length polymorphism (RFLP) analysis results confirmed that C4:2 was of the same lineage as A18. These cell lines provide an invaluable system to study the mechanism of ER expression and regulatory pathways leading to hormone-independent growth. The results here clearly demonstrate that the ER CpG island in C4:2 cells remains unmethylated. The loss of ER in the cell line must be due to mechanisms other than methylation. We also evaluated the ER CpG island in the MDA-MB-231:10A (10A) cell line, which is a clone from the MDA-MB-231 line obtained from ATCC and the DNA from the MDA-MB-231 cell line used in the original report. Unlike the cell line from the report, which showed a full methylation pattern in the island, the 10A line only showed a partial methylation pattern in the CpG island. Possible mechanisms pertaining to the heterogeneous methylation pattern of the ER CpG island in the breast cancer cells are discussed

    Educational psychologists' perspectives on the medicalisation of childhood behaviour: A focus on Attention Deficit Hyperactive Disorder (ADHD)

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    Aim: This study explores the views of Educational Psychologists (EPs) practising in the UK regarding the assessment, diagnosis and treatment of Attention Deficit Hyperactivity Disorder (ADHD). / Method: An online survey collected from 136 EPs, representing 70 local authorities across the UK. Findings: Responses highlighted how currently EPs are rarely engaged in the assessment of ADHD. However, the data indicated that EPs play an important role in increasing the awareness of contextual factors in children’s behaviour, and are well placed to support the development of individually tailored interventions. It was identified that in many local authorities, current diagnostic practices do not conform to government guidelines regarding both access to psychological interventions and the prescription of medication to pre¬school children. Furthermore, few children were involved in decision making about their treatment. Where Local Authorities have developed standardised pathways or protocols governing the diagnostic process, EPs are involved in the assessment process and children are more likely to access psychological interventions, and for contextual factors to be taken into account. / Limitations: Consistent with the research aims the study focuses exclusively on EP perspectives. As a survey it was not possible to probe for meaning or clarification of issues that emerged. There is a need for further research into successful examples of ADHD treatment pathways that take advantage of the unique contribution of EPs. / Conclusions: Priorities for future work include the need to develop a nationally agreed protocol for a multi-professional approach to assessment and treatment of ADHD. There is an urgent need for careful monitoring of prescription rates, particularly in pre-school children and across different ethnic and social groups. Furthermore, steps should be taken to address the lack of participation by children and young people in decisions about their treatment

    A self-test to detect a heart attack using a mobile phone and wearable sensors

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    Screening forCronobacterSpecies in Powdered and Reconstituted Infant Formulas and from Equipment Used in Formula Preparation in Maternity Hospitals

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    Background/Aims: Cronobacter spp. have been identified as being of considerable risk to neonates. The occurrence of organism in infant formulas is therefore of considerable interest. Methods: The occurrence of Cronobacter spp. in infant feeds (formulas and fortified cow’s milk) was determined using most probable number (MPN) analysis, and from formula preparation utensils. Ninety nine samples were analyzed, of which 42 were unopened cans of powdered infant formula (PIF), 25 reconstituted infant formulas in feeding bottles, 27 utensils used from the preparation of infant formula, and 5 samples of fortified cow’s milk. Presumptive Cronobacter spp. isolates were identified using the 7 allele multilocus sequence typing (MLST) scheme. Results: C. sakazakii, C. malonaticus and C. muytjensii were recovered from PIF. Although the incidence of Cronobacter in PIF was 29% (12/42), the level was low with an average of 0.54 MPN/100g. According to MLST profiling, C. sakazakii was the most frequently isolated Cronobacter species, and C. sakazakii ST4 (associated with neonatal meningitis) was recovered from 2/42 PIF samples at 0.51 and 0.92 MPN/100g. Conclusions: Cronobacter spp. can be isolated from PIF and therefore strict hygienic practices during PIF preparation are important to minimize neonate exposure and reduce the risk of severe infections

    Oscillating shear index, wall shear stress and low density lipoprotein accumulation in human RCAs

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    This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, Aristotle University of Thessaloniki, University of Thessaly, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute.Atherosclerosis shows predilection in regions of coronary arteries with hemodynamic particularities as, local disturbances of Wall Shear Stress (WSS) in space and time, and locally high concentrations of lipoprotein. Six, image-based human deceased, Right Coronary Arteries (RCA) are used to elucidate, a) Low Density Lipoprotein (LDL) transport under steady flow and b) oscillating flow (no mass transfer). A semi-permeable nature of the arterial wall computational model is incorporated with hydraulic conductivity and permeability treated as WSS dependent. The 3D reconstruction technique is a combination of angiography and IVUS. LDL is elevated at locations where WSS is low. Under steady flow conditions the area-averaged normalized LDL concentration over the RCAs, using shear dependent water infiltration and endothelial permeability is 9.6 % higher than at entrance. However, under constant water infiltration and endothelial permeability this value is only 3.2 %. High Oscillating Shear Index (OSI) and low average WSS nearly co-locate. Approximately 630000 grid nodes proved to be sufficient enough to accurately describe the oscillating flow and the LDL concentration within the RCAs

    Simulation of electromechanical responses of ferroelectric ceramics driven by alternating compressive stress and static electric field

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    Author name used in this publication: Simon Ching-kin Chow2008-2009 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe
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