Correlation between serum E-selectin levels and panoramic nailfold capillaroscopy in systemic sclerosis

E-selectin is expressed by the activated endothelium and its plasma levels are increased in patients with systemic sclerosis. Eighteen patients fulfilling the American Rheumatism Association criteria for systemic sclerosis, 15 females and 3 males, 42-70 years old, 9 with diffuse and 9 with limited forms, were sequentially recruited for this study. Serum E-selectin levels were determined by commercially available ELISA and their association with nailfold capillaroscopic abnormalities was investigated. Nailfold capillaries were analyzed by 16X magnification wide-field capillaroscopy. Two parameters on capillaroscopy were used to correlate to serum E-selectin: deletion and ectasia. Data were analyzed statistically by the Student t-test and Spearman correlation. Two-tailed P values below 0.05 were considered significant. E-selectin range was 38 to 200 ng/ml (80 ± 39.94). There was a correlation between serum E-selectin levels and the deletion capillaroscopic score (r = 0.50, P < 0.035). This correlation was even stronger within the first 48 months of diagnosis (r = 0.63, P < 0.048). On the other hand, no association was observed between selectin and ectasia. Patients with diffuse disease presented higher serum E-selectin levels than patients with limited disease, although the difference was not statistically significant (96.44 ± 48.04 vs 63.56 ± 21.77 ng/dl; P = 0.08). The present study is the first showing a correlation between soluble serum E-selectin levels and alterations in capillaroscopy. The stronger correlation of deletion score in capillaroscopy in early disease suggests that serum E-selectin levels might be a useful biochemical marker of disease activity in systemic sclerosis.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Divisão de ReumatologiaUNIFESP, EPM, Divisão de ReumatologiaSciEL

Wikis na produção textual colaborativa de notícias on-line em inglês como L2 no meio virtual: um estudo de caso

In this study, we observed the pedagogical potential of Wikis and their tools to support the process of collaborative learning. Our main aim was to understand how this technology can assist and favor the process of collaborative writing. Also, we aimed to investigate the influence of collaboration on the learning process and on the foreign language writing. This research was conducted in an undergraduate course at FALE UFMG. The study was grounded in theories of collaborative learning. In addition, it adopted a process and a genre orientation to writing instruction. The data collection instruments were questionnaires, the writings produced by the participants (individual and collaborative) and the observation of interactions in Wikispaces forum. The results showed that the wikis may: contribute to transform learners produsage capacities by creating opportunities to collaborate and produce knowledge; favor collective authoring and allow emphasis on the social dimensions of writing process. Moreover, it was possible to confirm the potential of the collaborative writing approach as we noticed that the contribution of each participant in the group work resulted in a better quality writing.Este trabalho teve como objetivo principal investigar o potencial pedagógico da plataforma Wiki e seus recursos como suporte no processo de aprendizagem colaborativa. Buscou-se com isso compreender como essa ferramenta pode auxiliar e favorecer o processo de escrita em colaboração. Além disso, o presente estudo buscou verificar a influência das dinâmicas colaborativas no processo de aprendizagem de escrita e na produção escrita em língua estrangeira. A pesquisa foi realizada em uma turma de graduandos da Faculdade de Letras da UFMG e teve como eixo teórico a aprendizagem colaborativa. Além disso, os procedimentos didáticos que fundamentaram o ensino de escrita na plataforma Wiki enfatizaram o caráter processual da escrita e o estudo das características do gênero notícia on-line. A coleta de dados foi efetivada por meio de questionário inicial, produções textuais de criadas pelos participantes (individuais e em colaboração), observação das interações registradas no fórum de discussão do Wikispaces e o questionário final. Com base nos resultados da pesquisa, constatou-se que a ferramenta Wiki pode: contribuir para transformar o modo produtivo de aprendizes criando oportunidades para colaborar e produzir conhecimento, privilegiar a autoria coletiva e possibilitar a ênfase na dimensão social do processo de escrita. Além disso, foi possível ratificar o potencial da abordagem pedagógica de escrita colaborativa ao verificar que a contribuição de cada participante no trabalho coletivo resultou em uma escrita de melhor qualidade

Prospects and analysis of the educational training process in the project with citizenship in the countryside

Este artigo possui como problema de pesquisa a Educação do Campo e a formação dos professores que nela atuam ‒ por meio da análise e discussão do trabalho pedagógico de educadoras participantes do Programa Nacional de Educação na Reforma Agrária (PRONERA), desenvolvido no âmbito da Educação do Campo e no chão da Educação de Jovens e Adultos ‒, tendo como objetivo de pesquisa reconhecer o envolvimento das educadoras do Projeto Tecendo a Cidadania no Campo, do polo de Flores/Formosa. Empreendemos uma metodologia de abordagem qualitativa com a realização de entrevistas semiestruturadas.&nbsp; A partir dos limites e desafios apontados pelas educadoras, foi possível identificar: a dificuldade em atualizar sua prática docente ao público da EJA; a falta de aproximação com uma abordagem de educação libertadora; a escassez de material didático e uma certa dificuldade com a escrita e leitura por parte das educadoras. Quanto às motivações e expectativas em relação ao projeto, foram apontadas pelas educadoras os seguintes pontos: o prazer de ensinar e poder participar de momentos de troca de experiências; a vontade de uma formação; a consciência e o dever de ajudar o próximo; a necessidade de alfabetização dentro do assentamento; a busca por melhorias na realidade; a formação de cidadãos mais conscientes; a contribuição na transformação da sociedade; e a realização pessoal com a certificação dos alunos ao final do processo. Palavras-chave: Educação do Campo, Educação de Jovens e Adultos, Emancipação. &nbsp; Prospects and analysis of the educational training process in the project with citizenship in the countryside ABSTRACT. This article has as a research problem the Rural Education and the training of the teachers who work in it ‒ through the analysis and discussion of the pedagogical work of educators participating in the National Program for Education in Agrarian Reform (PRONERA), developed in the scope of the Education of the Field and in the floor of the Education of Youths and Adults ‒, with the purpose of research recognizing the involvement of the educators of the Project Weaving Citizenship in the countryside, of the Flores/Formosa Polo. We undertake a methodology of qualitative approach with the accomplishment of semi structured interviews. From the limits and challenges pointed out by the educators, it was possible to identify: the difficulty in updating their teaching practice to the public of the EJA; the lack of rapprochement with an approach of liberating education; the shortage of didactic material and a certain difficulty with writing and reading by the educators. As for motivations and expectations regarding the project, the following points were pointed out by educators: the pleasure of teaching and being able to participate in moments of exchange of experiences; the desire for training; the conscience and duty to help others; the need for literacy within the settlement; the search for improvements in reality; the formation of more conscious citizens; the contribution to the transformation of society; and personal fulfillment with the certification of students at the end of the process. Keywords: Rural Education, Youth and Adult Education, Emancipation. &nbsp; Perspectivas y análisis del proceso formativo de educadores en el proyecto tecendo la ciudadanía en el campo RESUMEN. Este artículo tiene como problema de investigación la Educación del Campo y la formación de los profesores que en ella actúan ‒ por medio del análisis y discusión del trabajo pedagógico de educadoras participantes del Programa Nacional de Educación en la Reforma Agraria (PRONERA), que se desarrolló en el ámbito de la Educación del Campo y en el suelo de la Educación de Jóvenes y Adultos ‒, teniendo como objetivo de investigación reconocer el involucramiento de las educadoras del Proyecto Tejiendo la Ciudadanía en el Campo, del polo de Flores/Formosa. Se emprende una metodología de abordaje cualitativo con la realización de entrevistas semiestructuradas. A partir de los límites y desafíos señalados por las educadoras, fue posible identificar: la dificultad en actualizar su práctica docente al público de la EJA; la falta de aproximación con un enfoque de educación liberadora; la escasez de material didáctico y una cierta dificultad con la escritura y lectura por parte de las educadoras. En cuanto a las motivaciones y expectativas en relación al proyecto, fueron apuntadas por las educadoras los siguientes puntos: el placer de enseñar y poder participar de momentos de intercambio de experiencias; la voluntad de una formación; la conciencia y el deber de ayudar al prójimo; la necesidad de alfabetización dentro del asentamiento; la búsqueda de mejoras en la realidad; la formación de ciudadanos más conscientes; la contribución a la transformación de la sociedad; y la realización personal con la certificación de los alumnos al final del proceso. Palabras clave: Educación del Campo, Educación de Jóvenes y Adultos, Emancipación.ABSTRACT. This article has as a research problem the Rural Education and the training of the teachers who work in it ‒ through the analysis and discussion of the pedagogical work of educators participating in the National Program for Education in Agrarian Reform (PRONERA), developed in the scope of the Education of the Field and in the floor of the Education of Youths and Adults ‒, with the purpose of research recognizing the involvement of the educators of the Project Weaving Citizenship in the countryside, of the Flores/Formosa Polo. We undertake a methodology of qualitative approach with the accomplishment of semi structured interviews. From the limits and challenges pointed out by the educators, it was possible to identify: the difficulty in updating their teaching practice to the public of the EJA; the lack of rapprochement with an approach of liberating education; the shortage of didactic material and a certain difficulty with writing and reading by the educators. As for motivations and expectations regarding the project, the following points were pointed out by educators: the pleasure of teaching and being able to participate in moments of exchange of experiences; the desire for training; the conscience and duty to help others; the need for literacy within the settlement; the search for improvements in reality; the formation of more conscious citizens; the contribution to the transformation of society; and personal fulfillment with the certification of students at the end of the process.ABSTRACT. This article has as a research problem the Rural Education and the training of the teachers who work in it ‒ through the analysis and discussion of the pedagogical work of educators participating in the National Program for Education in Agrarian Reform (PRONERA), developed in the scope of the Education of the Field and in the floor of the Education of Youths and Adults ‒, with the purpose of research recognizing the involvement of the educators of the Project Weaving Citizenship in the countryside, of the Flores/Formosa Polo. We undertake a methodology of qualitative approach with the accomplishment of semi structured interviews. From the limits and challenges pointed out by the educators, it was possible to identify: the difficulty in updating their teaching practice to the public of the EJA; the lack of rapprochement with an approach of liberating education; the shortage of didactic material and a certain difficulty with writing and reading by the educators. As for motivations and expectations regarding the project, the following points were pointed out by educators: the pleasure of teaching and being able to participate in moments of exchange of experiences; the desire for training; the conscience and duty to help others; the need for literacy within the settlement; the search for improvements in reality; the formation of more conscious citizens; the contribution to the transformation of society; and personal fulfillment with the certification of students at the end of the process.RESUMEN. Este artículo tiene como problema de investigación la Educación del Campo y la formación de los profesores que en ella actúan ‒ por medio del análisis y discusión del trabajo pedagógico de educadoras participantes del Programa Nacional de Educación en la Reforma Agraria (PRONERA), que se desarrolló en el ámbito de la Educación del Campo y en el suelo de la Educación de Jóvenes y Adultos ‒, teniendo como objetivo de investigación reconocer el involucramiento de las educadoras del Proyecto Tejiendo la Ciudadanía en el Campo, del polo de Flores/Formosa. Se emprende una metodología de abordaje cualitativo con la realización de entrevistas semiestructuradas. A partir de los límites y desafíos señalados por las educadoras, fue posible identificar: la dificultad en actualizar su práctica docente al público de la EJA; la falta de aproximación con un enfoque de educación liberadora; la escasez de material didáctico y una cierta dificultad con la escritura y lectura por parte de las educadoras. En cuanto a las motivaciones y expectativas en relación al proyecto, fueron apuntadas por las educadoras los siguientes puntos: el placer de enseñar y poder participar de momentos de intercambio de experiencias; la voluntad de una formación; la conciencia y el deber de ayudar al prójimo; la necesidad de alfabetización dentro del asentamiento; la búsqueda de mejoras en la realidad; la formación de ciudadanos más conscientes; la contribución a la transformación de la sociedad; y la realización personal con la certificación de los alumnos al final del proceso

Microwave-assisted multicomponent synthesis of julolidines using silica-supported calix[4]arene as heterogeneous catalyst

The application of immobilizing calixarene onto the surface of silica using a sol-gel method, as an efficient heterogeneous catalyst (CX4SO3HSi(n)) for multicomponent Povarov reaction has been described. Catalytic activity of the CX4SO3HSi(n) for the synthesis of julolidines under greener and environmentally benign conditions in simple and efficient method was explored. Notably, only 0.5 mol% of the catalyst is sufficient to catalyze the Povarov solvent-free reaction under microwave-assistance. Besides, this protocol allows the construction of four new C-C bonds and two C-N bonds in a single step. To the best of our knowledge, this consists the first silica support calix[4]arene as a heterogeneous catalyst for multicomponent synthesis of julolidines.Fil: Ferreira de Paiva, Walysson. Universidade Federal de Viçosa. Departamento de Química.; BrasilFil: Bastos Braga, Ingredy. Universidade Federal de Viçosa. Departamento de Química.; BrasilFil: de Assis, João Vitor. Universidade Federal de Viçosa. Departamento de Química.; BrasilFil: Bonilla Castañeda, Sandra Milena. Universidade Federal de Viçosa. Departamento de Química.; BrasilFil: Sathicq, Ángel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Ciencias Aplicadas "Dr. Jorge J. Ronco". Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Ciencias Aplicadas; ArgentinaFil: Palermo, Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Ciencias Aplicadas "Dr. Jorge J. Ronco". Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Ciencias Aplicadas; ArgentinaFil: Romanelli, Gustavo Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Ciencias Aplicadas "Dr. Jorge J. Ronco". Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Ciencias Aplicadas; ArgentinaFil: Natalino, Ricardo. Universidade Federal de Viçosa. Departamento de Química.; BrasilFil: da Silva, Marcio José. Universidade Federal de Viçosa. Departamento de Química.; BrasilFil: Martins, Felipe Terra. Universidade Federal de Goiás; BrasilFil: de Carvalho, Gustavo Senra Gonçalves. Universidade Federal de Juiz de Fora; BrasilFil: Amarante, Giovanni Wilson. Universidade Federal de Juiz de Fora; BrasilFil: Fernandes, Sergio Antonio. Universidade Federal de Viçosa. Departamento de Química.; Brasi

Erica: Prevalences Of Hypertension And Obesity In Brazilian Adolescents

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)To estimate the prevalence of arterial hypertension and obesity and the population attributable fraction of hypertension that is due to obesity in Brazilian adolescents. METHODS: Data from participants in the Brazilian Study of Cardiovascular Risks in Adolescents (ERICA), which was the first national school-based, cross-section study performed in Brazil were evaluated. The sample was divided into 32 geographical strata and clusters from 32 schools and classes, with regional and national representation. Obesity was classified using the body mass index according to age and sex. Arterial hypertension was defined when the average systolic or diastolic blood pressure was greater than or equal to the 95th percentile of the reference curve. Prevalences and 95% confidence intervals (95% CI) of arterial hypertension and obesity, both on a national basis and in the macro-regions of Brazil, were estimated by sex and age group, as were the fractions of hypertension attributable to obesity in the population. RESULTS: We evaluated 73,399 students, 55.4% female, with an average age of 14.7 years (SD = 1.6). The prevalence of hypertension was 9.6% (95% CI 9.0-10.3); with the lowest being in the North, 8.4% (95% CI 7.7-9.2) and Northeast regions, 8.4% (95% CI 7.6-9.2), and the highest being in the South, 12.5% (95% CI 11.0-14.2). The prevalence of obesity was 8.4% (95% CI 7.9-8.9), which was lower in the North region and higher in the South region. The prevalences of arterial hypertension and obesity were higher in males. Obese adolescents presented a higher prevalence of hypertension, 28.4% (95% CI 25.5-31.2), than overweight adolescents, 15.4% (95% CI 17.0-13.8), or eutrophic adolescents, 6.3% (95% CI 5.6-7.0). The fraction of hypertension attributable to obesity was 17.8%. CONCLUSIONS: ERICA was the first nationally representative Brazilian study providing prevalence estimates of hypertension in adolescents. Regional and sex differences were observed. The study indicates that the control of obesity would lower the prevalence of hypertension among Brazilian adolescents by 1/5.501Brazilian Department of Science and Technology at the Secretariat of Science and TechnologyStrategic Inputs of the Ministry of Health (Departamento de Ciencia e Tecnologia da Secretaria de Ciencia e Tecnologia e Insumos Estrategicos do Ministerio da Saude - Decit/SCTIE/MS)Health Fund Sector (Fundo Setorial de Saude - CT-health) at the Ministry of science, Technology and Innovation (Ministerio da Ciencia, Tecnologia e Inovacao - MCTI)FINEP [01090421]CNPq [2010/565037-2]hospital research incentive fund for Clinics in Porto Alegre (fundo de incentivo a Pesquisa do Hospital de Clinicas de Porto Alegre - HCPA) [405,009/FIPE-2012-7]Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq

Erica: Prevalence Of Metabolic Syndrome In Brazilian Adolescents

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)To determine the prevalence of metabolic syndrome and its components in Brazilian adolescents. METHODS: We evaluated 37,504 adolescents who were participants in the Study of Cardiovascular Risks in Adolescents (ERICA), a cross-sectional, school-based, national study. The adolescents, aged from 12 to 17 years, lived in cities with populations greater than 100,000 inhabitants. The sample was stratified and clustered into schools and classes. The criteria set out by the International Diabetes Federation were used to define metabolic syndrome. Prevalences of metabolic syndrome were estimated according to sex, age group, school type and nutritional status. RESULTS: Of the 37,504 adolescents who were evaluated: 50.2% were female; 54.3% were aged from 15 to 17 years, and 73.3% were from public schools. The prevalence of metabolic syndrome was 2.6% (95% CI 2.3-2.9), slightly higher in males and in those aged from 15 to 17 years in most macro-regions. The prevalence was the highest in residents from the South macro-region, in the younger female adolescents and in the older male adolescents. The prevalence was higher in public schools (2.8% [95% CI 2.4-3.2]), when compared with private schools (1.9% [95% CI 1.4-2.4]) and higher in obese adolescents when compared with nonobese ones. The most common combinations of components, referring to 3/4 of combinations, were: enlarged waist circumference (WC), low HDL-cholesterol (HDL-c) and high blood pressure; followed by enlarged WC, low HDL-c and high triglycerides; and enlarged WC, low HDL-c, high triglycerides and blood pressure. Low HDL was the second most frequent component, but the highest prevalence of metabolic syndrome (26.8%) was observed in the presence of high triglycerides. CONCLUSIONS: ERICA is the first Brazilian nation-wide study to present the prevalence of metabolic syndrome and describe the role of its components. Despite the prevalence of Metabolic Syndrome being low, the high prevalences of some components and participation of others in the syndrome composition shows the importance of early diagnosis of this changes, even if not grouped within the metabolic syndrome.501Department of Science and Technology of the Secretariat of Science, Technology and Strategic Inputs of the Ministry of Health (Decit/SCTIE/MS)Health Sectorial Fund (Fundo Setorial de Saude - CT-Saude) of the Ministry of Science, Technology and Innovation (MCTI)FINEP [01090421]CNPq [2010/565037-2]Research Incentive Fund of the Hospital de Clinicas de Porto Alegre - (Fundo de Incentivo a Pesquisa do Hospital de Clinicas de Porto Alegre - FIPE-HCPA) [405.009/2012-7]Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq

Microwave-assisted multicomponent synthesis of julolidines using silica-supported calix[4]arene as heterogeneous catalyst

The application of immobilizing calixarene onto the surface of silica using a sol-gel method, as an efficient heterogeneous catalyst (CX4SO3HSi(n)) for multicomponent Povarov reaction has been described. Catalytic activity of the CX4SO3HSi(n) for the synthesis of julolidines under greener and environmentally benign conditions in simple and efficient method was explored. Notably, only 0.5 mol% of the catalyst is sufficient to catalyze the Povarov solvent-free reaction under microwave-assistance. Besides, this protocol allows the construction of four new C–C bonds and two C–N bonds in a single step. To the best of our knowledge, this consists the first silica support calix[4]arene as a heterogeneous catalyst for multicomponent synthesis of julolidines.Centro de Investigación y Desarrollo en Ciencias Aplicada

Brazilian recommendations on the safety and effectiveness of the yellow fever vaccination in patients with chronic immune-mediated inflammatory diseases

Background: In Brazil, we are facing an alarming epidemic scenario of Yellow fever (YF), which is reaching the most populous areas of the country in unvaccinated people. Vaccination is the only effective tool to prevent YF. In special situations, such as patients with chronic immune-mediated inflammatory diseases (CIMID), undergoing immunosuppressive therapy, as a higher risk of severe adverse events may occur, assessment of the risk-benefit ratio of the yellow fever vaccine (YFV) should be performed on an individual level. Main body of the abstract: Faced with the scarcity of specific orientation on YFV for this special group of patients, the Brazilian Rheumatology Society (BRS) endorsed a project aiming the development of individualized YFV recommendations for patients with CIMID, guided by questions addressed by both medical professionals and patients, followed an internationally validated methodology (GIN-McMaster Guideline Development). Firstly, a systematic review was carried out and an expert panel formed to take part of the decision process, comprising BRS clinical practitioners, as well as individuals from the Brazilian Dermatology Society (BDS), Brazilian Inflammatory Bowel Diseases Study Group (GEDIIB), and specialists on infectious diseases and vaccination (from Tropical Medicine, Infectious Diseases and Immunizations National Societies); in addition, two representatives of patient groups were included as members of the panel. When the quality of the evidence was low or there was a lack of evidence to determine the recommendations, the decisions were based on the expert opinion panel and a Delphi approach was performed. A recommendation was accepted upon achieving ≥80% agreement among the panel, including the patient representatives. As a result, eight recommendations were developed regarding the safety of YFV in patients with CIMID, considering the immunosuppression degree conferred by the treatment used. It was not possible to establish recommendations on the effectiveness of YFV in these patients as there is no consistent evidence to support these recommendations. Conclusion: This paper approaches a real need, assessed by clinicians and patient care groups, to address specific questions on the management of YFV in patients with CIMID living or traveling to YF endemic areas, involving specialists from many areas together with patients, and might have global applicability, contributing to and supporting vaccination practices. We recommended a shared decision-making approach on taking or not the YFV