Radiomics for Response and Outcome Assessment for Non-Small Cell Lung Cancer.

Routine follow-up visits and radiographic imaging are required for outcome evaluation and tumor recurrence monitoring. Yet more personalized surveillance is required in order to sufficiently address the nature of heterogeneity in nonsmall cell lung cancer and possible recurrences upon completion of treatment. Radiomics, an emerging noninvasive technology using medical imaging analysis and data mining methodology, has been adopted to the area of cancer diagnostics in recent years. Its potential application in response assessment for cancer treatment has also drawn considerable attention. Radiomics seeks to extract a large amount of valuable information from patients' medical images (both pretreatment and follow-up images) and quantitatively correlate image features with diagnostic and therapeutic outcomes. Radiomics relies on computers to identify and analyze vast amounts of quantitative image features that were previously overlooked, unmanageable, or failed to be identified (and recorded) by human eyes. The research area has been focusing on the predictive accuracy of pretreatment features for outcome and response and the early discovery of signs of tumor response, recurrence, distant metastasis, radiation-induced lung injury, death, and other outcomes, respectively. This review summarized the application of radiomics in response assessments in radiotherapy and chemotherapy for non-small cell lung cancer, including image acquisition/reconstruction, region of interest definition/segmentation, feature extraction, and feature selection and classification. The literature search for references of this article includes PubMed peer-reviewed publications over the last 10 years on the topics of radiomics, textural features, radiotherapy, chemotherapy, lung cancer, and response assessment. Summary tables of radiomics in response assessment and treatment outcome prediction in radiation oncology have been developed based on the comprehensive review of the literature

Converting Treatment Plans From Helical Tomotherapy to L-Shape Linac: Clinical Workflow and Dosimetric Evaluation.

This work evaluated a commercial fallback planning workflow designed to provide cross-platform treatment planning and delivery. A total of 27 helical tomotherapy intensity-modulated radiotherapy plans covering 4 anatomical sites were selected, including 7 brain, 5 unilateral head and neck, 5 bilateral head and neck, 5 pelvis, and 5 prostate cases. All helical tomotherapy plans were converted to 7-field/9-field intensity-modulated radiotherapy and volumetric-modulated radiotherapy plans through fallback dose-mimicking algorithm using a 6-MV beam model. The planning target volume (PTV) coverage ( D1, D99, and homogeneity index) and organs at risk dose constraints were evaluated and compared. Overall, all 3 techniques resulted in relatively inferior target dose coverage compared to helical tomotherapy plans, with higher homogeneity index and maximum dose. The organs at risk dose ratio of fallback to helical tomotherapy plans covered a wide spectrum, from 0.87 to 1.11 on average for all sites, with fallback plans being superior for brain, pelvis, and prostate sites. The quality of fallback plans depends on the delivery technique, field numbers, and angles, as well as user selection of structures for organs at risk. In actual clinical scenario, fallback plans would typically be needed for 1 to 5 fractions of a treatment course in the event of machine breakdown. Our results suggested that <1% dose variance can be introduced in target coverage and/or organs at risk from fallback plans. The presented clinical workflow showed that the fallback plan generation typically takes 10 to 20 minutes per case. Fallback planning provides an expeditious and effective strategy for transferring patients cross platforms, and minimizing the untold risk of a patient missing treatment(s)

First Report of NRG Oncology/Radiation Therapy Oncology Group 0622: A Phase 2 Trial of Samarium-153 Followed by Salvage Prostatic Fossa Irradiation in High-Risk Clinically Nonmetastatic Prostate Cancer After Radical Prostatectomy.

PURPOSE: To investigate the utility of 153Sm lexidronam (Quadramet) in the setting of men with prostate cancer status post radical prostatectomy who develop biochemical failure with no clinical evidence of osseous metastases. PATIENTS AND METHODS: Trial NRG Oncology RTOG 0622 is a single-arm phase 2 trial that enrolled men with pT2-T4, N0-1, M0 prostate cancer status post radical prostatectomy, who meet at least 1 of these biochemical failure criteria: (1) prostate-specific antigen (PSA) \u3e 1.0 ng/mL; (2) PSA \u3e 0.2 ng/mL if Gleason score 9 to 10; or (3) PSA \u3e 0.2 ng/mL if N1. Patients received 153Sm (2.0 mCi/kg intravenously × 1) followed by salvage external beam radiation therapy (EBRT) to the prostatic fossa (64.8-70.2 Gy in 1.8-Gy daily fractions). No androgen deprivation therapy was allowed. The primary objective was PSA response within 12 weeks of receiving 153Sm. The secondary objectives were to: (1) assess the completion rate for the regimen of 153Sm and EBRT; (2) evaluate the hematologic toxicity and other adverse events (AEs) at 12 and 24 weeks; and (3) determine the freedom from progression rate at 2 years. RESULTS: A total of 60 enrolled eligible patients were included in this analysis. Median follow-up was 3.97 years. A PSA response was achieved in 7 of 52 evaluable patients (13.5%), compared with the 25% hypothesized. The 2-year freedom from progression rate was 25.5% (95% confidence interval 14.4%-36.7%), and the biochemical failure rate was 64.4% (95% CI 50.5%-75.2%). Samarium-153 was well tolerated, with 16 (of 60) grade 3 to 4 hematologic AEs and no grade 5 hematologic AEs. Radiation therapy was also well tolerated, with no grade 3 to 5 acute radiation therapy-related AEs and 1 grade 3 to 4 and no grade 5 late radiation therapy-related AEs. CONCLUSIONS: Trial NRG Oncology RTOG 0622 did not meet its primary endpoint of PSA response, although the regimen of 153Sm and salvage EBRT was well tolerated. Although the toxicity profile supports study of 153Sm in high-risk disease, it may not be beneficial in men receiving EBRT

A Cone Beam CT-Based Study For Clinical Target Definition Using Pelvic Anatomy During Post-Prostatectomy Radiotherapy

Introduction: Radiation therapy (RT) is delivered after radical prostatectomy (RP) either as salvage treatment for an elevated prostate-specific antigen (PSA) level1-6 or as adjuvant therapy for patients with highrisk pathologic features7-8. Recent prospective data demonstrated a disease-free survival benefit of adjuvant RT for pathologic T3N0 prostate cancer9-10. Despite literature supporting the delivery of post-RP RT to the prostatic fossa (PF), no clear target definition guidelines exist for intensity modulated radiation therapy (IMRT) or image-guided RT (IGRT)11. Visualization of the PF is limited on standard CT images, with significant interobserver variability and uncertainty in CTV definition12. Efforts to incorporate complementary imaging modalities such as MRI for PF target volume definition have generated neither demonstrably more reliable PF delineation, nor practical contouring guidelines13. Regardless of the imaging modality, direct visualization and delineation of the PF clinical target volume (CTV) is fraught with uncertainty. On the other hand, it is possible to distinguish the borders of important nearby pelvic structures, namely the bladder and the rectum. The reliability of rectal volume definition on helical CT is supported by analysis of rectal contours defined in a prospective trial, suggesting the feasibility of rectal dose-volume data collection in a multicenter setting14. Fiorino et al have described a correlation between PF CTV shift and anterior rectal wall shift for the cranial half of the rectum in their report of rectal and bladder movement during post-RP RT using weekly CT images15. These studies support the reliability of CT-defined rectum contours and a limited correlation between PF CTV and anterior rectal wall, an important tenet in the current study. Int. J. Radiation Oncol. Biol. Physics, Volume 70, Issue 2, pages 431-436, Feb. 1, 2008

Radioactive seed immobilization techniques for interstitial brachytherapy

Purpose In prostate brachytherapy, seeds can detach from their deposited sites and move locally in the pelvis or migrate to distant sites including the pulmonary and cardiac regions. Undesirable consequences of seed migration include inadequate dose coverage of the prostate and tissue irradiation effects at the site of migration. Thus, it is clinically important to develop seed immobilization techniques. Methods We first analyze the possible causes for seed movement, and propose three potential techniques for seed immobilization: (1) surgical glue, (2) laser coagulation and (3) diathermy coagulation. The feasibility of each method is explored. Experiments were carried out using fresh bovine livers to investigate the efficacy of seed immobilization using surgical glue. Results Results have shown that the surgical glue can effectively immobilize the seeds. Evaluation of the radiation dose distribution revealed that the non-immobilized seed movement would change the planned isodose distribution considerably; while by using surgical glue method to immobilize the seeds, the changes were negligible. Conclusions Prostate brachytherapy seed immobilization is necessary and three alternative mechanisms are promising for addressing this issue. Experiments for exploring the efficacy of the other two proposed methods are ongoing. Devices compatible with the brachytherapy procedure will be designed in futur

The Tangled Web: How Nonprofit Board Members Experience Organizational Crisis

The purpose of this grounded theory study was to develop an understanding of what board members experience during a time of organizational crisis. Major corporate and nonprofit failures of previously successful organizations in recent years have raised questions and led to speculation about the role of boards of directors through the crises. In this study twenty board members of nonprofit organizations who had experienced an organizational crisis during their board service were interviewed. Participants were asked to share their perceptions and explore how they identified and made meaning of the events and board processes that went on as the crisis became apparent and progressed. The overall research design was grounded theory guided by Schatzman’s and Charmaz’ methodological contributions. A dimensional analysis was employed to create explanatory matrices that focused on theory development. From dimensional analysis the core dimension, the Tangled Web, and primary dimensions Recognizing, Responding, and Stepping Up emerged. The model of a Tangled Web depicts the processes that obstruct a board’s ability to recognize and respond to signs of crisis. Complexity theory, governance, crisis and turnaround, and group process all contribute to the understanding of the research question. The electronic version of this dissertation is available through the OhioLink ETD Center, www.ohiolink.edu/et

The Tangled Web: How Nonprofit Board Members Experience Organizational Crisis

The purpose of this grounded theory study was to develop an understanding of what board members experience during a time of organizational crisis. Major corporate and nonprofit failures of previously successful organizations in recent years have raised questions and led to speculation about the role of boards of directors through the crises. In this study twenty board members of nonprofit organizations who had experienced an organizational crisis during their board service were interviewed. Participants were asked to share their perceptions and explore how they identified and made meaning of the events and board processes that went on as the crisis became apparent and progressed. The overall research design was grounded theory guided by Schatzman’s and Charmaz’ methodological contributions. A dimensional analysis was employed to create explanatory matrices that focused on theory development. From dimensional analysis the core dimension, the Tangled Web, and primary dimensions Recognizing, Responding, and Stepping Up emerged. The model of a Tangled Web depicts the processes that obstruct a board’s ability to recognize and respond to signs of crisis. Complexity theory, governance, crisis and turnaround, and group process all contribute to the understanding of the research question. The electronic version of this dissertation is available through the OhioLink ETD Center, www.ohiolink.edu/et

Mini-GPTs: Efficient Large Language Models through Contextual Pruning

In AI research, the optimization of Large Language Models (LLMs) remains a significant challenge, crucial for advancing the field's practical applications and sustainability. Building upon the foundational work of Professor Song Han's lab at MIT, this paper introduces a novel approach in developing Mini-GPTs via contextual pruning. Our methodology strategically prunes the computational architecture of traditional LLMs, like Phi-1.5, focusing on retaining core functionalities while drastically reducing model sizes. We employ the technique across diverse and complex datasets, including US law, Medical Q&A, Skyrim dialogue, English-Taiwanese translation, and Economics articles. The results underscore the efficiency and effectiveness of contextual pruning, not merely as a theoretical concept but as a practical tool in developing domain-specific, resource-efficient LLMs. Contextual pruning is a promising method for building domain-specific LLMs, and this research is a building block towards future development with more hardware compute, refined fine-tuning, and quantization.Comment: 7 pages, 4 figures, Neurips 2023 stylin

Le determinanti delle collaborazioni di ricerca università-impresa nei settori ad alta tecnologia

LAUREA MAGISTRALEQuesta elaborato di tesi riguarda un’analisi esaustiva delle collaborazioni di ricerca Università-Impresa in Italia. Abbiamo studiato tutte le determinanti delle collaborazioni innovative e le decisioni delle imprese riguardo alle collaborazioni accademiche sono influenzate sia dalla prossimità geografica, sia da altre dimensioni di prossimità. In particolare è rilevante il ruolo della prossimità sociale, o l’importanza dei network accademici, la prossimità culturale e la dimensione cognitiva fra imprese e università. L’elaborato esamina anche la composizione dei team creativi, del prestigio accademico e delle loro connessioni con le collaborazioni Università-Impresa. Nello specifico abbiamo esaminato le collaborazioni di ricerca fra giovani imprese innovative (start up, imprese operanti nell’alta tecnologia, spin off accademici) e università italiane. Basandoci sui dati dal 2000 al 2008, i risultati mostrano che essere geograficamente vicini aumenta le probabilità di collaborare con istituzioni accademiche. Inoltre tutte le altre forme di prossimità, in accordo con un’amplia letteratura, sono comunque significative per la propensione alle collaborazioni universitarie. Abbiamo infine riscontrato che l’impatto della “diversity ” del team di ricerca dei soci fondatori e il prestigio accademico non sono significativi per le collaborazioni Università-Impresa. Questo è particolarmente vero per imprese high-tech, start up e spin-off accademici fortemente orientati all’attività di ricerca.This dissertation concerns a comprehensive analysis of formal University-Industry research collaborations in Italy. We investigate all the determinants of innovative collaboration and it’s argued that firm’s decisions to collaborate with universities (for innovation) are influenced by both geographical proximity to university, and all other dimensions of proximity. In particular it’s relevant the role of social proximity, or the importance of the academic networking, the role of cultural proximity and the cognitive dimension between firms and universities. This thesis also investigates the composition of industry creative teams, the academic prestige and their connections with research collaborations. Specifically we examine University-Industry alliances between Italian universities and young innovative firms (technological ventures, start up, academic spin off). Based on Italian data from 2000 to 2008, the findings show that being close to a university increases the propensity of collaboration. All the other dimensions of proximity (social, cultural and cognitive), according with a large body of literature, are still significant for the propensity of university research collaborations. We also find that the impact of diversity in research team and the prestige of universities are not significant for academic collaborations. This is particularly true for high-research and development intensive firms