Portraiture in the head and neck cancer clinic: a patient’s perspective

I first met Scottish artist Mark Gilbert in 2013 as a participant in his Ph.D. dissertation study, “The Experience of Portraiture in Clinical Settings” [EPICS]. I was introduced to the study during a follow-up appointment with my head and neck cancer surgeon. Twelve years earlier, at the age of fifty-three, I was diagnosed with squamous cell carcinoma on my tongue, which was removed surgically along with corresponding lymph nodes. I also underwent radiotherapy. Prior to EPICS, Mark had collaborated with physicians and patients on several projects that sought to use art, specifically portraiture, to explore notions of illness, recovery, care, and caregiving. During these studies, Mark became acutely aware of how fundamental the intimate nature of the relationships and interactions between participants and himself were to the portrait-making process. He realized the connections made with each person were as diverse as the participants themselves and responded to their voices, both silent and spoken, to guide and inform the marks he made on the canvas

Recognizing a MIS-Chievous Cause of Acute Viral Gastroenteritis

Historically, children evaluated for vomiting and diarrhea secondary to viral enteritis have symptoms lasting 2-4 days and respond to supportive care, including oral rehydration and anti-emetics if required. Recently, within a 14-day timespan, we encountered three children with severe diarrhea who rapidly became dehydrated and went into hypotensive shock. Although SARS-CoV-2 molecular tests were negative by nasopharyngeal swab, all were later found to have MIS-C. This small case series underscores features reported in previous larger studies and emphasizes the rapid clinical evolution of this condition. We highlight the importance of early recognition of cardinal laboratory findings characteristic of MIS-C (i.e., lymphopenia, markedly elevated acute phase reactants, and hypoalbuminemia). We also show serologic evidence that the pathophysiological mechanism of SARS-CoV-2 related diarrhea may differ from other causes of dehydrating vomiting and diarrhea, with no serologic evidence of villus cell injury

Fungi: Friend or Foe? A Mycobiome Evaluation in Children with Autism and Gastrointestinal Symptoms

Gastrointestinal (GI) symptoms often affect children with autism spectrum disorders (ASD) and GI symptoms have been associated with an abnormal fecal microbiome. There is limited evidence of Candida species being more prevalent in children with ASD. We enrolled 20 children with ASD and GI symptoms (ASD + GI), 10 children with ASD but no GI symptoms (ASD - GI), and 20 from typically developing (TD) children in this pilot study. Fecal mycobiome taxa were analyzed by Internal Transcribed Spacer sequencing. GI symptoms (GI Severity Index [GSI]), behavioral symptoms (Social Responsiveness Scale -2 [SRS-2]), inflammation and fungal immunity (fecal calprotectin and serum dectin-1 [ELISA]) were evaluated. We observed no changes in the abundance of total fungal species (alpha diversity) between groups. Samples with identifiable Candida spp. were present in 4 of 19 (21%) ASD + GI, in 5 of 9 (56%) ASD - GI, and in 4 of 16 (25%) TD children (overall P = 0.18). The presence of Candida spp. did not correlate with behavioral or GI symptoms (P = 0.38, P = 0.5, respectively). Fecal calprotectin was normal in all but one child. Finally, there was no significance in serum dectin-1 levels, suggesting no increased fungal immunity in children with ASD. Our data suggest that fungi are present at normal levels in the stool of children with ASD and are not associated with gut inflammation

Software Engineering Processes Used to Develop the NIF Integrated Computer Control System

We have developed a new target platform to study Laser Plasma Interaction in ignition-relevant condition at the Omega laser facility (LLE/Rochester)[1]. By shooting an interaction beam along the axis of a gas-filled hohlraum heated by up to 17 kJ of heater beam energy, we were able to create a millimeter-scale underdense uniform plasma at electron temperatures above 3 keV. Extensive Thomson scattering measurements allowed us to benchmark our hydrodynamic simulations performed with HYDRA [1]. As a result of this effort, we can use with much confidence these simulations as input parameters for our LPI simulation code pF3d [2]. In this paper, we show that by using accurate hydrodynamic profiles and full three-dimensional simulations including a realistic modeling of the laser intensity pattern generated by various smoothing options, fluid LPI theory reproduces the SBS thresholds and absolute reflectivity values and the absence of measurable SRS. This good agreement was made possible by the recent increase in computing power routinely available for such simulations

15th Annual Environmental Law Institute

Materials from the 15th Annual Environmental Law Institute held by UK/CLE in March 1999

Status of the National Ignition Facility Integrated Computer Control System (ICCS) on the Path to Ignition

The National Ignition Facility (NIF) at the Lawrence Livermore National Laboratory is a stadium-sized facility under construction that will contain a 192-beam, 1.8-Megajoule, 500-Terawatt, ultraviolet laser system together with a 10-meter diameter target chamber with room for multiple experimental diagnostics. NIF is the world's largest and most energetic laser experimental system, providing a scientific center to study inertial confinement fusion (ICF) and matter at extreme energy densities and pressures. NIF's laser beams are designed to compress fusion targets to conditions required for thermonuclear burn, liberating more energy than required to initiate the fusion reactions. NIF is comprised of 24 independent bundles of 8 beams each using laser hardware that is modularized into more than 6,000 line replaceable units such as optical assemblies, laser amplifiers, and multifunction sensor packages containing 60,000 control and diagnostic points. NIF is operated by the large-scale Integrated Computer Control System (ICCS) in an architecture partitioned by bundle and distributed among over 800 front-end processors and 50 supervisory servers. NIF's automated control subsystems are built from a common object-oriented software framework based on CORBA distribution that deploys the software across the computer network and achieves interoperation between different languages and target architectures. A shot automation framework has been deployed during the past year to orchestrate and automate shots performed at the NIF using the ICCS. In December 2006, a full cluster of 48 beams of NIF was fired simultaneously, demonstrating that the independent bundle control system will scale to full scale of 192 beams. At present, 72 beams have been commissioned and have demonstrated 1.4-Megajoule capability of infrared light. During the next two years, the control system will be expanded to include automation of target area systems including final optics, target positioners and diagnostics, in preparation for project completion in 2009. Additional capabilities to support fusion ignition shots in a National Ignition Campaign (NIC) beginning in 2010 will include a cryogenic target system, target diagnostics, and integrated experimental shot data analysis with tools for data visualization and archiving. This talk discusses the current status of the control system implementation and discusses the plan to complete the control system on the path to ignition

Shot Automation for the National Ignition Facility

A shot automation framework has been developed and deployed during the past year to automate shots performed on the National Ignition Facility (NIF) using the Integrated Computer Control System This framework automates a 4-8 hour shot sequence, that includes inputting shot goals from a physics model, set up of the laser and diagnostics, automatic alignment of laser beams and verification of status. This sequence consists of set of preparatory verification shots, leading to amplified system shots using a 4-minute countdown, triggering during the last 2 seconds using a high-precision timing system, followed by post-shot analysis and archiving. The framework provides for a flexible, model-based execution driven of scriptable automation called macro steps. The framework is driven by high-level shot director software that provides a restricted set of shot life cycle state transitions to 25 collaboration supervisors that automate 8-laser beams (bundles) and a common set of shared resources. Each collaboration supervisor commands approximately 10 subsystem shot supervisors that perform automated control and status verification. Collaboration supervisors translate shot life cycle state commands from the shot director into sequences of ''macro steps'' to be distributed to each of its shot supervisors. Each Shot supervisor maintains order of macro steps for each subsystem and supports collaboration between macro steps. They also manage failure, restarts and rejoining into the shot cycle (if necessary) and manage auto/manual macro step execution and collaborations between other collaboration supervisors. Shot supervisors execute macro step shot functions commanded by collaboration supervisors. Each macro step has database-driven verification phases and a scripted perform phase. This provides for a highly flexible methodology for performing a variety of NIF shot types. Database tables define the order of work and dependencies (workflow) of macro steps to be performed for a shot. A graphical model editor facilitates the definition and viewing of an execution model. A change manager tool enables ''de-participation'' of individual devices, of entire laser segments (beams, quads, or bundles of beams) or individual diagnostics. This software has been deployed to the NIF facility and is currently being used to support NIF main laser commissioning shots and build-out of the NIF laser. This will be used to automate future target and experimental shot campaigns

Economies of size of Illinois cash-grain & hog farms

Cover title.Includes bibliographical references