Walvoord, Jeane Oral History Interview: Old China Hands Oral History Project I and II

This project was made possible by a grant from the Youthgrants 1n the Humanities Program of the National Endowment for the Humanities, a Federal agency established by Congress to promote research, education,and public activity in the humanities

Hill, Jack Warren Oral History Interview: Old China Hands Oral History Project

This project was made possible by a grant from the Youthgrants 1n the Humanities Program of the National Endowment for the Humanities, a Federal agency established by Congress to promote research, education,and public activity in the humanities

Veldman, Jeannette Oral History Interview: Old China Hands Oral History Project I and II

This project was made possible by a grant from the Youthgrants 1n the Humanities Program of the National Endowment for the Humanities, a Federal agency established by Congress to promote research, education,and public activity in the humanities

Veldman, Harold E and Pearl Oral History Interview: Old China Hands Oral History Project

This project was made possible by a grant from the Youthgrants 1n the Humanities Program of the National Endowment for the Humanities, a Federal agency established by Congress to promote research, education,and public activity in the humanities

Occupational Therapy Interventions for Visual Impairments among Adolescents with Mild Traumatic Brain Injury

PUPROSE: The purpose of this systematic review was to synthesize the evidence of occupational therapy (OT) interventions for adolescents who have sustained a mTBI and experience visual dysfunction. DESIGN AND METHOD: A systematic review of peer-reviewed literature was conducted. Articles were included if participants were eight to nineteen years of age and diagnosed with an mTBI. Titles and abstracts of 506 articles from three databases were screened. The full text of 26 articles was reviewed. Seven met inclusion criteria. The U.S. Preventive Services Task Force levels of certainty and grade definitions described the strength of evidence. RESULTS: Physical conditioning, vision therapy, and device usage emerged as interventions for improving visual function for adolescents post-mTBI. Physical conditioning and vision therapy had moderate strength of evidence. Physical conditioning interventions like aerobic exercises, core strengthening, and balance training should be used for 30 seconds to 30 minutes, daily to 2 times per week, for 3 to 4 weeks. Vision therapy should be utilized under the subthemes of ocular motility, binocularity, and visual vestibular processing 2 times per week from 4 to 23 weeks. Device usage had low strength of evidence. Computer gaming glasses or electronic rapid alternate occlusion with liquid crystal glasses can be used on a case-by-case basis. CONCLUSIONS: Present research supports the routine use of physical conditioning and vision therapy for adolescents with visual impairments post-mTBI. Device use can be considered on a case-by-case basis. Future studies should further explore occupation-centered interventions for this group to enhance their visual function in everyday tasks.https://digitalcommons.unmc.edu/cahp_ot_sysrev/1015/thumbnail.jp

Diary Entry of Geisje Vander Haar Visscher

Geisje Vander Haar Visscher\u27s diary contains an entry on page 13, in which she made a reference to both Albertus C. Van Raalte and to Mrs. Christina Van Raalte. An entry for 1849 on p. 10 said that the Van Raaltes often came to visit the Vander Haars. The 1856 reference is about the High School and bringing it into a better condition. This is a reference to the Pioneer School. She also said Mr. Van Vleck had come to the school. She thought that Mrs. Van Vleck was a lovely person. The Vander Haar apparently got to know the Van Vlecks well.https://digitalcommons.hope.edu/vrp_1850s/1334/thumbnail.jp

Intergenerational support networks and fertility in Rwanda

Thesis (M.A.)--Michigan State University. Department of Sociology, 1990Includes bibliographical references (pages 58-61

Structure of the human mTOR Complex I and its implications for rapamycin inhibition

The mammalian target of rapamycin complex 1 (mTORC1) regulates cell growth in response to the nutrient and energy status of the cell, and its deregulation is common in human cancers. Little is known about the overall architecture and subunit organization of this essential signaling complex. We have determined the three-dimensional (3D) structure of the fully assembled human mTORC1 by cryo-electron microscopy (cryo-EM). Our analyses reveal that mTORC1 is an obligate dimer with an overall rhomboid shape and a central cavity. The dimeric interfaces are formed by interlocking interactions between the mTOR and raptor subunits. Extended incubation with FKBP12-rapamycin compromises the structural integrity of mTORC1 in a stepwise manner, leading us to propose a model in which rapamycin inhibits mTORC1-mediated phosphorylation of 4E-BP1 and S6K1 through different mechanisms.National Institutes of Health (U.S.) (Grant AI47389)National Institutes of Health (U.S.) (Grant CA103866)United States. Dept. of Defense (W81XWH-07-1-0448)W. M. Keck Foundatio

Erythropoietin mediated bone formation is regulated by mTOR signaling

The role of erythropoietin (Epo) and Epo/Epo receptor (EpoR) signaling pathways for production of red blood cells are well established. However, little is known about Epo/EpoR signaling in non‐hematopoietic cells. Recently, we demonstrated that Epo activates JAK/STAT signaling in hematopoietic stem cells (HSCs), leading to the production of bone morphogenetic protein 2 (BMP2) and bone formation and that Epo also directly activates mesenchymal cells to form osteoblasts in vitro. In this study, we investigated the effects of mTOR signaling on Epo‐mediated osteoblastogenesis and osteoclastogenesis. We found that mTOR inhibition by rapamycin blocks Epo‐dependent and ‐independent osteoblastic phenotypes in human bone marrow stromal cells (hBMSCs) and ST2 cells, respectively. Furthermore, we found that rapamycin inhibits Epo‐dependent and ‐independent osteoclastogenesis in mouse bone marrow mononuclear cells and Raw264.7 cells. Finally, we demonstrated that Epo increases NFATc1 expression and decreases cathepsin K expression in an mTOR‐independent manner, resulting in an increase of osteoclast numbers and a decrease in resorption activity. Taken together, these results strongly indicate that mTOR signaling plays an important role in Epo‐mediated bone homeostasis. J. Cell. Biochem. 113: 220–228, 2012. © 2011 Wiley Periodicals, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/89548/1/23347_ftp.pd