SB 106 Congressional and state legislative districts; standards and criteria

This report examines Senate Bill (SB) 106, introduced during the 2018 Virginia General Assembly session to address the criterion of redistricting and the specific impact on racial and ethnic minorities. This legislation is a direct response to previous legislative attempts to address gerrymandering and remains an evolving issue in the Commonwealth

Transportation Barriers to Healthcare in Adults 65+ in the Greater Burlington Area

Introduction. Missed appointments often lead to poorer health care outcomes for patients and pose a major economic burden on medical centers. Transportation is an obstacle to accessing medical care for elderly patients in Vermont and results in delayed medical appointments. Methods. We surveyed senior citizens in Chittenden county to determine both the type of transportation barriers and medical care missed due to the lack of transpor- tation. An original survey assessing the impact of transportation to health care was distributed in person and through an online platform. Participants were asked to identify the following in the past year: how often transportation was an issue for healthcare, specific barriers to transportation, and which specific health care appointments were missed due to lack of transportation. Ninety-six surveys out of a total of 251 collected were included in the analysis. Respondents were grouped into either having high transportation barriers, n=43, (always, often, sometimes had issues in the past year), or low transportation barriers, n=53, (rarely had issues). Results. The high barriers group reported more missed appointments, with eye appointments being the most frequent, and depended more on other modes of trans- portation. The low barriers group was able to drive themselves to their appointments more often. Conclusion. The results suggest a trend between barriers to transportation and a lack of access to healthcare appointments. Although more than half of the survey respondents indicated that they do not currently experience transportation barriers, many expressed concern about the transportation difficulties they could encounter in the future.https://scholarworks.uvm.edu/comphp_gallery/1263/thumbnail.jp

Local Skin Inflammation in Cutaneous Leishmaniasis as a Source of Variable Pharmacokinetics and Therapeutic Efficacy of Liposomal Amphotericin B.

Disfiguring skin lesions caused by several species of the Leishmania parasite characterize cutaneous leishmaniasis (CL). Successful treatment of CL with intravenous (i.v.) liposomal amphotericin B (LAmB) relies on the presence of adequate antibiotic concentrations at the dermal site of infection within the inflamed skin. Here, we have investigated the impact of the local skin inflammation on the pharmacokinetics (PK) and efficacy of LAmB in two murine models of localized CL (Leishmania major and Leishmania mexicana) at three different stages of disease (papule, initial nodule, and established nodule). Twenty-four hours after the administration of one 25 mg/kg of body weight LAmB (i.v.) dose to infected BALB/c mice (n = 5), drug accumulation in the skin was found to be dependent on the causative parasite species (L. major > L. mexicana) and the disease stage (papule > initial nodule > established nodule > healthy skin). Elevated tissue drug levels were associated with increased vascular permeability (Evans blue assay) and macrophage infiltration (histomorphometry) in the infected skin, two pathophysiological parameters linked to tissue inflammation. After identical treatment of CL in the two models with 5 × 25 mg/kg LAmB (i.v.), intralesional drug concentrations and reductions in lesion size and parasite load (quantitative PCR [qPCR]) were all ≥2-fold higher for L. major than for L. mexicana In conclusion, drug penetration of LAmB into CL skin lesions could depend on the disease stage and the causative Leishmania species due to the influence of local tissue inflammation

Relation between Skin Pharmacokinetics and Efficacy in AmBisome Treatment of Murine Cutaneous Leishmaniasis.

AmBisome (LAmB), a liposomal formulation of amphotericin B (AmB), is a second-line treatment for the parasitic skin disease cutaneous leishmaniasis (CL). Little is known about its tissue distribution and pharmacodynamics to inform clinical use in CL. Here, we compared the skin pharmacokinetics of LAmB with those of the deoxycholate form of AmB (DAmB; trade name Fungizone) in murine models of Leishmania major CL. Drug levels at the target site (the localized lesion) 48 h after single intravenous (i.v.) dosing of the individual AmB formulations (1 mg/kg of body weight) were similar but were 3-fold higher for LAmB than for DAmB on day 10 after multiple administrations (1 mg/kg on days 0, 2, 4, 6, and 8). After single and multiple dosing, intralesional concentrations were 5- and 20-fold, respectively, higher than those in the healthy control skin of the same infected mice. We then evaluated how drug levels in the lesion after LAmB treatment relate to therapeutic outcomes. After five administrations of the drug at 0, 6.25, or 12.5 mg/kg (i.v.), there was a clear correlation between dose level, intralesional AmB concentration, and relative reduction in parasite load and lesion size (R2 values of >0.9). This study confirms the improved efficacy of the liposomal over the deoxycholate AmB formulation in experimental CL, which is related to higher intralesional drug accumulation

The Effect of the Sophomore Slump on Students’ Persistence

For years, universities have focused on student admissions and getting students through their first-year. According to Schaller (2010), this has resulted in limited literature and research regarding the persistence of sophomore students. From Fall 2010 to Fall 2015, the University of New Mexico (UNM) has experienced a decrease in the persistence of its cohorts from the third to the fifth semester. The existence of this higher attrition rate amongst sophomore students has been associated with a phenomenon known as the “sophomore slump” (Tobolowsky & Cox, 2007). The purpose of this research study was to utilize student retention conceptual models to explore the effect of the sophomore slump on sophomore students’ persistence. It included an examination and statistical analysis of several variables that impacted the retention or persistence of a sample of sophomore students at UNM. This research study was conducted using a descriptive quantitative methodology. The variables associated with the pre-entry attributes, cognitive, academics, social engagements, and financial categories were merged into five conceptual models as a mean to investigate if there was a correlational statistical significance within their relationships on the effect of the sophomore slump. Overall, the statistical results of this research study revealed that the two of the financial variables (i.e., lottery scholarship and performance-based scholarship) had the most significant impact on the persistence of sophomore students at the University of New Mexico

Closing the gap on causal processes of infection risk from cross-sectional data:structural equation models to understand infection and co-infection

BACKGROUND: Epidemiological studies of disease exposure risk are frequently based on observational, cross-sectional data, and use statistical approaches as crucial tools for formalising causal processes and making predictions of exposure risks. However, an acknowledged limitation of traditional models is that the inferred relationships are correlational, cannot easily distinguish direct from indirect determinants of disease risk, and are often considerable simplifications of complex interrelationships. This may be particularly important when attempting to infer causality in patterns of co-infection through pathogen-facilitation. METHODS: We describe analyses of cross-sectional data using structural equation models (SEMs), a contemporary advancement on traditional regression approaches, based on our study system of feline gammaherpesvirus (FcaGHV1) in domestic cats. RESULTS: SEMs strongly supported a latent (host phenotype) variable associated with FcaGHV1 exposure and co-infection risk, suggesting these individuals are simply more likely to become infected with multiple pathogens. However, indications of pathogen-covariance (potential facilitation) were also variably detected: potentially among FcaGHV1, Bartonella spp and Mycoplasma spp. CONCLUSIONS: Our models suggest multiple exposures are primarily driven by host phenotypic traits, such as aggressive male phenotypes, and secondarily by pathogen-pathogen interactions. The results of this study demonstrate the application of SEMs to understanding epidemiological processes using observational data, and could be used more widely as a complementary tool to understand complex cross-sectional information in a wide variety of disciplines

Polling ‘misses’ – can Q-methodology help? A case study of the Seanad referendum

Accurate information on public opinion is a necessary condition for the effective functioning of democracies. For Lasswell, the open interplay of public opinion with policy is the ‘distinguishing mark of popular rule’ [Lasswell, H. D. (1941). Democracy through public opinion. Menasha, WI: Banta]. Yet, despite its importance, there is a distinct gap in methods and tools to understand large volumes of public opinion statements on any issue. The 2013 referendum in Ireland on the abolition of the Seanad (Senate) was a prominent example of this gap. Opinion polls were perceived as misleading in suggesting that the referendum was going to pass. Aiming to address opinion noise, and the polarity suggested by opinion polls, we conducted an online study of subjectivity in the week before polling. Using Q-methodology and the stream of public opinion generated during the campaign, we identified three main perspectives on the issue of Seanad abolition. One perspective was in favour of abolition, two opposed the proposal. We conclude that Q-methodology could be used to support opinion polling and political communication by providing a supporting context of the range of social perspectives on the issue at hand

Re-envisioning Community-Engaged Healing for Black Women

Black women in the United States continue to face multilayered forms of anti-Black gendered oppression leading to severe health disparities and inequities that have a dire impact on their well-being. This paper recognizes the urgency to attend to Black women’s health and healing in the pursuit of creating health equity. The authors call for the creation of sacred spaces for Black women to participate in embodied and community-engaged healing, grounded in a gender justice that is inextricably tied to racial justice. This research is inspired by the long, rich line of Black American women activist-healers that have called for the radical healing of Black women. Therefore, the authors root their work in an ethical health justice ethos, honoring the humanity of Black women through a recognition of their sacredness, guided by the principles of justice, truth-telling, love, and respect that emphasizes that Black women’s lives matter. Using an interdisciplinary approach, the authors braid together healing narratives from the fields of Public Health, Black Psychology, Africana Studies, and Gender, Women’s, and Sexuality Studies. Underscoring the importance of Black women reclaiming their radical healing, this paper at the same time underlines resisting anti-Black gendered racism and interlocking forms of oppression. The authors emphasize gender and racial justice while endorsing collectivistic orientations, grounded in an African-centered worldview, that support Black women’s embodied and community-engaged healing. As a result, the authors also draw from healing narratives in their fields that include cultural paradigms, socially engaged spirituality, and generational and gendered wisdom. Connecting historical to present-day medical/mental health encounters, the authors underscore inhumane, racist, and sexist pseudoscience, medical treatment, and research experiments on Black women’s bodies. The authors also address social injustices, isolation, and (dis)ease while foregrounding gender and racial justice in the creation of health equity for Black women