Effect of organic manures and silicon nutrition on the productivity and profitability of rice

Field experiments were conducted in 2022 and 2023 during the Kharif season at experimental farm, Department of Agronomy, Annamalai University, Tamil Nadu, India to study the effect of organic manures and silicon nutrition on the productivity and profitability of rice. The treatments included both organic manures (farmyard manure (FYM), green manure (GM), poultry manure (PM)) and recommended doses of fertilizers (RDF)). Silicon through Diatomaceous earth (DE) was tested in combination with the above nutrient sources. The treatments were arranged in randomized block design with three replications. The highest growth parameters (plant height, number of tillers hill-1, leaf area index and dry matter production), yield parameters (number of panicles m-2, number of filled grains panicles-1 and Test weight) and rice yields (grain and straw yields) were found in both seasons with RDF + GM @ 6.25 t ha-1 + PM @ 2 t ha-1 + Si @ 200 kg ha-1.  However, applying RDF + PM @ 2 t ha-1 + Si @ 200 kg ha-1 through DE increased net income and benefit cost ratio in 2022 and 2023. Based on the results of two-year field experiment, it can be concluded that rice productivity and profitability can be improved through the application of RDF + PM @ 2 t ha-1 + Si @ 200 kg ha-1 through DE

Long Non-Coding RNAs (lncRNAs) in Heart Failure: A Comprehensive Review

Heart failure (HF) is a widespread cardiovascular condition that poses significant risks to a wide spectrum of age groups and leads to terminal illness. Although our understanding of the underlying mechanisms of HF has improved, the available treatments still remain inadequate. Recently, long non-coding RNAs (lncRNAs) have emerged as crucial players in cardiac function, showing possibilities as potential targets for HF therapy. These versatile molecules interact with chromatin, proteins, RNA, and DNA, influencing gene regulation. Notable lncRNAs like Fendrr, Trpm3, and Scarb2 have demonstrated therapeutic potential in HF cases. Additionally, utilizing lncRNAs to forecast survival rates in HF patients and distinguish various cardiac remodeling conditions holds great promise, offering significant benefits in managing cardiovascular disease and addressing its far-reaching societal and economic impacts. This underscores the pivotal role of lncRNAs in the context of HF research and treatment

Emerging Strategies for Revascularization: Use of Cell-Derived Extracellular Vesicles and Artificial Nanovesicles in Critical Limb Ischemia

Critical limb ischemia (CLI) poses a substantial and intricate challenge in vascular medicine, necessitating the development of innovative therapeutic strategies to address its multifaceted pathophysiology. Conventional revascularization approaches often fail to adequately address the complexity of CLI, necessitating the identification of alternative methodologies. This review explores uncharted territory beyond traditional therapies, focusing on the potential of two distinct yet interrelated entities: cell-derived extracellular vesicles (EVs) and artificial nanovesicles. Cell-derived EVs are small membranous structures naturally released by cells, and artificial nanovesicles are artificially engineered nanosized vesicles. Both these vesicles represent promising avenues for therapeutic intervention. They act as carriers of bioactive cargo, including proteins, nucleic acids, and lipids, that can modulate intricate cellular responses associated with ischemic tissue repair and angiogenesis. This review also assesses the evolving landscape of CLI revascularization through the unique perspective of cell-derived EVs and artificial nanovesicles. The review spans the spectrum from early preclinical investigations to the latest translational advancements, providing a comprehensive overview of the current state of research in this emerging field. These groundbreaking vesicle therapies hold immense potential for revolutionizing CLI treatment paradigms