Simple and stereospecific homologation of urethane-protected alpha-amino acids to their higher homologs using HBTU1

A simple, efficient and stereospecific approach for the homologation of urethane-protected a-amino acids to beta-amino acids by the Arndt-Eistert method employing Fmoc-/Boc-alpha-amino acid and 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyl-uronium hexafluorophosphate mixture for the acylation of diazomethane synthesizing the key intermediates Fmoc-/Boc-alpha-aminodiazomethanes as crystalline solids is described

Training fisherwomen in fish processing

A project on training fisherwomen for their participation in rural development, sponsored by Ford Foundation (U.S.A), has been started by the Centre for Agricultural and Rural Development Studies, T.N AU.,at the Fisheries College, Tuticorin. The project alms to select a few literate rural women with leadership qualities for Imparting to them a training In the organisational and managerial aspects of a viable fish processing enterprise. It also alms to assist the trained fisherwomen in organising and operating cottage industries by continued technical backing and thus making the production units demonstration centres for the benefit of other women In the region. The preliminary survey helped in identifying 5 candidates from each of the 3 selected villages. The pre-survey revealed the respondents' choice of subject-areas to undergo training and their enthusiasm to learn techniques for the preparation of fish products like fish pickle and MasI Meen. It also revealed their desire to be exposed to new products like fish wafers, fish oil, fish meal, shark fin-rays etc. The pre- and post evaluations of the training programme helped In I) identifying training needs In the fields of marketing and financial management; II) Identifying some low-cost technological substitutes for some of the commercial products (eg: 'Gadi' for vineger); ill) identifying the products or techniques appreciated by the trainees and the products or techniques that received lukewarm response with reasons for such a response: Iv) Identifying the level of managerial efficiency gained by the trainees and the kind of support required for each Individual to start cottage industries. The programme Is being followed up by Interpersonal contacts and the co-ordinate efforts of the development departments

Homologation of alpha-amino acids to beta-amino acids using Boc(2)O

The use of Boc(2)O as a coupling agent in the homologation of N-urethane protected-alpha-amino acid to its beta-homomers by the Arndt-Eistert method is described. The homologation gives good yields without racemization. The use of Boc(2)O as a coupling agent not only allows the easy scale up of the process but also it is cost effective

Molecular identification of hookworm isolates in humans, dogs and soil in a tribal area in Tamil Nadu, India

Background : Hookworms (Necator americanus and Ancylostoma duodenale) remain a major public health problem worldwide. Infections with hookworms (e.g., A. caninum, A. ceylanicum and A. braziliense) are also prevalent in dogs, but the role of dogs as a reservoir for zoonotic hookworm infections in humans needs to be further explored. Methodology/Principal Findings : As part of an open-label community based cluster-randomized trial in a tribal area in Tamil Nadu (India; 2013-2015), a total of 143 isolates of hookworm eggs from human stool were speciated based on a previously described PCR-RFLP methodology. The presence of hookworm DNA was confirmed in 119 of 143 human samples. N. americanus (100%) was the most prevalent species, followed by A. caninum (16.8%) and A. duodenale (8.4%). Because of the high prevalence of A. caninum in humans, dog samples were also collected to assess the prevalence of A. caninum in dogs. In 68 out of 77 canine stool samples the presence of hookworms was confirmed using PCR-RFLP. In dogs, both A. caninum (76.4%) and A. ceylanicum (27.9%) were identified. Additionally, to determine the contamination of soil with zoonotic hookworm larvae, topsoil was collected from defecating areas. Hookworm DNA was detected in 72 out of 78 soil samples that revealed presence of hook-worm-like nematode larvae. In soil, different hookworm species were identified, with animal hookworms being more prevalent (A. ceylanicum: 60.2%, A. caninum: 29.4%, A. duodenale: 16.6%, N. americanus: 1.4%, A. braziliense: 1.4%). Conclusions/Significance : In our study we regularly detected the presence of A. caninum DNA in the stool of humans. Whether this is the result of infection is currently unknown but it does warrant a closer look at dogs as a potential reservoir

Microwave assisted Wolff rearrangement: A facile method for the synthesis of Fmoc-β-amino acids

The Wolff rearrangement of α-diazoketones, derived from Fmoc-α-amino acids, under no base conditions on exposure to microwave irradiation for 40 to 60 sec to Fmoc-β-amino acids with retention of configuration in good yield (91-95%) is described

N-Silylation of amines and amino acid esters under neutral conditions employing TMS-Cl in the presence of zinc dust

An expedient synthetic approach to N-silylamines has been developed. The protocol, using TMS-Cl/zinc dust instead of BSA, is useful for the conversion of amines or amino acid esters to the corresponding silyl derivatives, followed by acylation with an acyl chloride or Fmoc-amino acid chloride to give the corresponding amide or peptide. This procedure, affording products in good to excellent yields, is also efficient for the coupling of sterically hindered amino acids like α,α-dialkylamino acids and NMe-amino acids. Further, the use of an equimolar quantity of organic base, such as Et 3N/pyridine, is circumvented. © 2005 Published by Elsevier Ltd

Direct synthesis of Fmoc protected amino acid hydroxamates from acid chlorides mediated by magnesium oxide

The synthesis of Fmoc protected amino acid hydroxamates using Fmoc-amino acid chlorides and magnesium oxide is described. The method is simple and efficient, results in complete conversion, and gives good yields and satisfactory purity. © 2003 Elsevier Science Ltd. All rights reserved

Multi Level Inverter Under Unbalanced Voltage Conditions

A Multilevel Inverter(MLI) is a power electronic device built to synthesize a desired A.C voltage from several levels of DC voltages. Generally unbalanced voltages will occur at supply side these can be eliminated by using Multi level Inverter. In this paper a closed loop Control system is designed using PI controller in order to maintain load voltage constant for under voltage and Over voltage conditions and MATLAB simulations have been carried out