A study of anxiety and depression in Vitiligo patients: New challenges to treat

IntroductionVitiligo, a dermatological problem, affects a person's emotional and psychological well being, having major consequences on patient's life. Most of the patients of vitiligo report embarrassment, helpless and low self esteem.AimsTo study socio-demographic profile and psychiatric comorbidities and their correlation with site of lesion in vitiligo patients.Methods and material100 vitiligo patients and 100 subjects as control group who were well enough to complete the assessment were assessed with a semi-structured self designed Proforma, Hospital Anxiety Depression Scale (HADS) to obtain the relevant information. Data so obtained were tabulated, analyzed and conclusions were drawn using suitable statistics (i.e. Chi2).Results79% of vitiligo patients were between age 13 to 45 years, 67% were males, 33% were females patients in study group. In comparison to healthy controls, the psychiatric morbidity was found to be significantly higher in the vitiligo group (62% v/s 25%). 37%, 18%, and 7% vitiligo patients suffered from Mixed anxiety and depressive disorder, Depressive disorder and Generalized anxiety disorder respectively. Incidence of psychiatric morbidity was higher in patients who had lesions more on exposed body areas.ConclusionsVitiligo affected marital, sex life and intimacy. This generates psychological distress and disrupts the social relationship and creates a vicious stress-vitiligo cycle. Among vitiligo cases, psychiatric morbidity was found more frequent in young participants and higher in patients having lesions on exposed body areas.Disclosure of interestThe author has not supplied his/her declaration of competing interest.</jats:sec

<i>Musa paradisiaca </i>stem juice as a source of peroxidase and ligninperoxidase

1036-1040Musa paradisiaca stem juice has been shown to contain peroxidase activity of the order of 0.1 enzyme unit /ml. The Kill values of this peroxidase for the substrates guaiacol and hydrogen peroxide are 2.4 and 0.28 mM respectively. The pH and temperature optima arc 4.5 and 62.5°C respectively. Like other peroxidases, it follows double displacement type mechanism. At low pH, Musa paradisiaca stem juice exhibits ligninperoxidase type activity. The pH optimum for ligninperoxidase type activity is 2.0 and the temperature optimum is 24°C. The Km values for veratryl alcohol and n-propanol are 66 and 78 μM respectively

Purification of a peroxidase from Solanum melongena fruit juice

239-243Solanum melongena fruit juice contains peroxidase activity of the order of 0×125 IU/mL. A method for the 11-fold purification of the enzyme was developed. The Km values of the peroxidase for the substrates guaiacol and hydrogen peroxide were 6×5 mM and 0×33 mM, respectively. The pH and temperature optima were 5×5 and 84°C, respectively using guaiacol as the substrate. Sodium azide and phenyl hydrazine inhibited the enzyme competitively

Galactose oxidase immobilised on <i>Ocimum sanctum </i>seeds for the enzymatic preparations of L-glucose, L-galactose and L-xylose

218-222Galactose oxidase has been immobilised on a solid support developed by modification and activation of surface of Ocimum sanctum seeds. The conversions of xylitol to L-xylose; galactitol to L-galactose and D-sorbitol to L-glucose using the above immobilised enzyme preparation have been shown. Galactose oxidase co-immobilised with catalase increases the conversion yields. Conversion of D-sorbitol to L-glucose using the immobilised galactose oxidase in a mini flow bed reactor has been demonstrated. </span

Enzymatic Preparation of L-Glucose, L-Galactose and L-Xylose Using Galactose oxidase Immobilised on Crab-shell Particles

361-365Galactose oxidase has been immobilised on a solid support developed by modification and activation of surfaces of crab-shell particles. The conversion of D-sorbitol to L-glucose, galactitol to L-galactose and xylitol to L-xylose using the immobilised galactose oxidase have been demonstrated. The performance of the immobilised galactose oxidase for the conversion of D-sorbitol to L-glucose in a mini batch reactor has been studied. The advantages of this method for preparing L-sugars have been discussed