The AfterBabyBodyStudy: Muscular changes, exercising, and activity limitations and their associations with pelvic girdle pain and urinary incontinence in the postpartum period

Aim: Pregnancy and childbirth can lead to several symptoms, changes in the pelvic floor muscles and a diastasis recti abdominis (DRA). This thesis aimed to assess and explore stress urinary incontinence, vaginal heaviness, pelvic girdle pain and muscular changes in the postpartum period, in relation to each other, and in relation to exercising, activity limitations and women’s experiences. Methods: This thesis comprises four papers based on a prospective longitudinal cohort study (n = 504) and a qualitative study (n = 14). The cohort study included questionnaires and clinical muscle assessments at 3, 6, 9 and 12 months postpartum, with double initial assessments (n = 222) to assess inter-rater reliability (Paper I). The questionnaires included measures to assess pelvic girdle pain (Papers II+III), stress urinary incontinence, vaginal heaviness and exercising (Paper III) and activity limitations (Paper IV). The qualitative study involved interviews regarding women’s experiences of physical changes and recovery postpartum (Paper IV). These 14 women were not included in the cohort study. Results: Good inter-rater reliability was shown for the assessment of maximal voluntary pelvic floor muscle contraction using vaginal palpation and for measuring DRA width with a caliper, but only fair inter-rater reliability for the assessment of pelvic floor muscle relaxation (Paper I). There were associations between weak pelvic floor muscles and DRA width ≥35 mm and increased pelvic girdle pain severity at 3 months postpartum. Participants with lower pelvic girdle pain severity showed no statistically significant decrease from 3 to 12 months postpartum (Paper II). Participants who engaged in low-impact exercise 2-4 times/week within the first 3 postpartum months experienced reduced pelvic girdle pain and stress urinary incontinence severity at 12 months compared to 3 months postpartum. Those who did not exercise experienced increased stress urinary incontinence at 12 months postpartum (Paper III). Women experienced activity limitations, e.g., running, exercising, and lifting/carrying, due to pain, vaginal heaviness, and urinary incontinence in the first 6 months. While most of these limitations were temporary, 41% of women continued to experience difficulties with running 12 months postpartum (Paper IV-cohort). The women were surprised by the physical changes postpartum. They expressed a need to understand whether these changes were permanent or temporary (Paper IV-interview). Conclusion: Several symptoms and physical changes naturally diminish during the first year postpartum. However, urinary incontinence and pelvic girdle pain can result in activity limitations. Women can feel surprised and insecure about these physical changes and seek support and practical advice on how to manage them. Primary care physiotherapists could play an important role for women with persistent symptoms and activity limitations in assessing their pelvic floor and abdominal muscles, encouraging and adjusting exercise, and helping to restore function in muscle groups associated with pain and urinary incontinence

Die Tagesschau-App und die Notwendigkeit der Schaffung eines "Intermedienkollisionsrechts"

The article takes up the example of online news-services to describe the overall purpose of Germany\u27s public broadcasting corporation within the new networks of electronic media. It argues that the rise of the Internet is an evolutionary jump in the history of media. For this reason the traditional constitutional regime of guaranteeing pluralism in broadcasting can no longer be applied as a rationale and justification. Rather, a new constitutional type of conflict of law rules should be inaugurated to cope with the rising economic competition between public and private online news-services

Die Staatsrechtslehre und die Veränderung ihres Gegenstandes. Gewährleistung von Freiheit und Sicherheit im Lichte unterschiedlicher Staats- und Verfassungsverständnisse. Risikosteuerung durch Verwaltungsrecht. Transparente Verwaltung - Konturen...Berichte und Diskussionen auf der Tagung der Vereinigung der Deutschen Staatsrechtslehrer in Hamburg vom 1. bis 4. Oktober 2003

This volume presents the lectures and discussions held at the conference of the "Vereinigung der deutschen Staatsrechtslehrer" (the association of german professors for public law), October 1st - Ocober 3rd, 2003, Hamburg

Spatial and single-cell profiling of the metabolome, transcriptome and epigenome of the aging mouse liver

Tissues within an organism and even cell types within a tissue can age with different velocities. However, it is unclear whether cells of one type experience different aging trajectories within a tissue depending on their spatial location. Here, we used spatial transcriptomics in combination with single-cell ATAC-seq and RNA-seq, lipidomics and functional assays to address how cells in the male murine liver are affected by age-related changes in the microenvironment. Integration of the datasets revealed zonation-specific and age-related changes in metabolic states, the epigenome and transcriptome. The epigenome changed in a zonation-dependent manner and functionally, periportal hepatocytes were characterized by decreased mitochondrial fitness, whereas pericentral hepatocytes accumulated large lipid droplets. Together, we provide evidence that changing microenvironments within a tissue exert strong influences on their resident cells that can shape epigenetic, metabolic and phenotypic outputs