Buildings and users with visual impairment::uncovering factors for accessibility using BIT-Kit

In this paper, we report on the experiences of visually impaired users in navigating buildings. We focus on an investigation of the way-finding experiences by 10 participants with varying levels of visual ability, as they undertook a way-finding task in an unfamiliar public building. Through applying the BIT-Kit framework in this preliminary user study, we were able to uncover 54 enabling and disabling interactions within the case study building. While this building adhered to building legislation, our findings identified a number of accessibility problems including, issues associated with using doors, hazards caused by building finishes, and difficulty in knowing what to do in the case of an emergency evacuation. This user study has demonstrated a disparity between design guidance and the accessibility needs of building users. It has uncovered evidence to enable architects to begin to design for the real needs of users who have a range of visual impairment. Furthermore, it has instigated discussion of how BIT-Kit's evidence could be incorporated into digital modelling tools currently used in architectural practice

Connecting the Dots: Stages of Implementation, Wraparound Fidelity and Youth Outcomes

Several necessary system and organizational support conditions for wraparound have been identified (Walker et al. 2003). Yet, the relationship between these necessary system level conditions and wraparound fidelity has only recently begun to be examined. Similarly, few studies have included a measure of wraparound fidelity when examining the relationship between wraparound implementation and youth outcomes. The statewide implementation of a wraparound demonstration grant offers the opportunity to explore these relationships and to identify factors that predict improvement in functioning for youth receiving wraparound. Findings suggest that significant relationships exist between (1) the stage of development of necessary support conditions for wraparound and wraparound fidelity and (2) wraparound fidelity and improvement in youth outcomes. Specific elements of wraparound (i.e., outcomes based and community based) and baseline needs and strengths (e.g., high levels of anxiety and conduct issues, poor functioning at home and in school, judgment, and risks) were found to predict a reduction in youth needs. Other unexpected relationships between youth outcomes and the cultural competence element of wraparound and being multi-racial were also discovered. These findings reinforce the importance of supporting high fidelity wraparound for youth and their families in a recovery focused behavioral health system

Pneumococcal conjugate vaccines PREVenar13 and SynflorIX in sequence or alone in high-risk Indigenous infants (PREV-IX_COMBO): protocol of a randomised controlled trial.

INTRODUCTION: Otitis media (OM) starts within weeks of birth in almost all Indigenous infants living in remote areas of the Northern Territory (NT). OM and associated hearing loss persist from infancy throughout childhood and often into adulthood. Educational and social opportunities are greatly compromised. Pneumococcus and non-typeable Haemophilus influenzae (NTHi) are major OM pathogens that densely colonise the nasopharynx and infect the middle ear from very early in life. Our hypothesis is that compared to current single vaccine schedules, a combination of vaccines starting at 1 month of age, may provide earlier, broadened protection. METHODS AND ANALYSES: This randomised outcome assessor, blinded controlled trial will recruit 425 infants between 28 and 38 days of age and randomly allocate them (1:1:1) to one of three pneumococcal conjugate vaccine (PCV) schedules: Synflorix at 2, 4, 6 months of age, Prevenar13 at 2, 4 and 6 months of age, or an investigational schedule of Synflorix at 1, 2 and 4 months plus Prevenar13 at 6 months of age. The blinded primary outcomes at 7 months of age are immunogenicity of specific vaccine antigens (geometric mean concentration (GMC) and proportion of participants with above threshold GMC of 0.35 µg/L). Secondary outcomes at all timepoints are additional immunogenicity measures and proportion of participants with nasopharyngeal carriage of vaccine-type pneumococci and NTHi, and any OM, including any tympanic membrane perforation. Parental interviews will provide data on common risk factors for OM. ETHICS AND DISSEMINATION: Ethical approval has been obtained from NT Department of Health and Menzies HREC (EC00153), Central Australian HREC (EC00155) and West Australian Aboriginal Health Ethics Committee (WAAHEC- 377-12/2011). Final trial results, data analyses, interpretation and conclusions will be presented in appropriate written and oral formats to parents and guardians, participating communities, local, national and international conferences, and published in peer-reviewed open access journals. TRIAL REGISTRATION NUMBERS: ACTRN12610000544077 and NCT01174849

Experiences of (re)developing an online digital skills awareness course: practical implications for supporting widespread implementation of open educational resources

Open educational resources (OERs) are materials made freely available for others to use and adapt to support their educational practices. In 2019, the Bloomsbury Learning Exchange (BLE) created a Digital Skills Awareness Course (DSAC) to support digital skills development and transition into Higher Education (HE) for students across its six partner institutions in London. Subsequently, the BLE took the unusual step to release the entire course as an OER thereby making it available for educators across UK HE to use and edit to fit their own educational context. Five years on, this study sought to evaluate how and in which contexts the DSAC had been implemented across UK HE institutions using an explanatory mixed-methods approach. We conducted an online survey of those who had signed up to receive a copy of the course (n = 54). Of the twelve respondents, eleven had implemented the DSAC at their institution and edited the course to include links to institution-specific support and resources. To further interrogate participants’ experiences of using the course, we conducted five semi-structured interviews and, using thematic analysis, identified two themes that captured participants’ experiences: ‘The DSAC lays the foundation to explore digital capabilities’ and ‘It’s me driving it forward (with the help of others)’. This case study demonstrates that the DSAC provides a much-needed starting point for professional and academic staff to implement digital skills training for new students. We found that the DSAC was being used both as a generic institutional or discipline-specific course and that learning technology and senior management support was integral to successful implementation. Future work should include staff-student partnership to further develop the resource and should seek to explore how best practices and iterative changes to OERs can be shared back to the community, ensuring that materials remain relevant for adopters and tomorrow’s students

Evolving the Face of a Criminal: How to Search a Face Space More Effectively

Witnesses and victims of serious crime are often required to construct a facial composite, a visual likeness of a suspect’s face. The traditional method is for them to select individual facial features to build a face, but often these images are of poor quality. We have developed a new method whereby witnesses repeatedly select instances from an array of complete faces and a composite is evolved over time by searching a face model built using PCA. While past research suggests that the new approach is superior, performance is far from ideal. In the current research, face models are built which match a witness’s description of a target. It is found that such ‘tailored’ models promote better quality composites, presumably due to a more effective search, and also that smaller models may be even better. The work has implications for researchers who are using statistical modelling techniques for recognising faces

Catching more offenders with EvoFIT facial composites: Lab research and Police field trials.

Often, the only evidence of an offender’s identity comes from the memory of an eyewitness. For over 12 years, we have been developing software called EvoFIT to help eyewitnesses recover their memories of offenders’ faces, to assist police investigations. EvoFIT requires eyewitnesses to repeatedly select from arrays of faces, with ‘breeding’, to ‘evolve’ a face. Recently, police forces have been formally evaluating EvoFIT in criminal cases. The current paper describes four such police audits. It is reported that EvoFIT composites directly led to an arrest in 25.4% of cases overall; the arrest rate was 38.5% for forces that used a newer, less detailed face-recall interview. These results are similar to those found in the laboratory using simulated procedures. Here, we also evaluate the impact of interviewing techniques and outline further work that has improved system performance

Risks of mining to salmonid-bearing watersheds

Mining provides resources for people but can pose risks to ecosystems that support cultural keystone species. Our synthesis reviews relevant aspects of mining operations, describes the ecology of salmonid-bearing watersheds in northwestern North America, and compiles the impacts of metal and coal extraction on salmonids and their habitat. We conservatively estimate that this region encompasses nearly 4000 past producing mines, with present-day operations ranging from small placer sites to massive open-pit projects that annually mine more than 118 million metric tons of earth. Despite impact assessments that are intended to evaluate risk and inform mitigation, mines continue to harm salmonid-bearing watersheds via pathways such as toxic contaminants, stream channel burial, and flow regime alteration. To better maintain watershed processes that benefit salmonids, we highlight key windows during the mining governance life cycle for science to guide policy by more accurately accounting for stressor complexity, cumulative effects, and future environmental change.This review is based on an October 2019 workshop held at the University of Montana Flathead Lake Biological Station (more information at https://flbs.umt.edu/ newflbs/research/working-groups/mining-and-watersheds/). We thank E. O’Neill and other participants for valuable contributions. A. Beaudreau, M. LaCroix, P. McGrath, K. Schofield, and L. Brown provided helpful reviews of earlier drafts. Three anonymous reviewers provided thoughtful critiques that greatly improved the manuscript. The views expressed in this article are those of the authors and do not necessarily represent the views or policies of the U.S. Environmental Protection Agency. Our analysis comes from a western science perspective and hence does not incorporate Indigenous knowledge systems. We acknowledge this gap and highlight that the lands and waters we explore in this review have been stewarded by Indigenous Peoples for millennia and continue to be so. Funding: The workshop was cooperatively funded by the Wilburforce Foundation and The Salmon Science Network funded by the Gordon and Betty Moore Foundation. Author contributions: C.J.S. led the review process, writing, and editing. C.J.S. and E.K.S. co-organized the workshop. E.K.S. and J.W.M. extensively contributed to all aspects of the review conceptualization, writing, and editing. A.R.W., S.A.N., J.L.E., D.M.C., S.L.O., R.L.M., F.R.H., D.C.W., and J.W. significantly contributed to portions of the review conceptualization, writing, and editing. J.C., M.Ca., M.Co., C.A.F., G.K., E.D.L., R.M., V.M., J.K.M., M.V.M., and N.S. provided writing and editing and are listed alphabetically. Competing interests: The authors declare that they have no competing interests. Data and materials availability: All data needed to evaluate the conclusions in the paper are present in the paper and/or the Supplementary Materials.Ye

Working to improve survival and health for babies born very preterm: The WISH project protocol

Background: Babies born very preterm (before 30 weeks gestation) are at high risk of dying in their first weeks of life, and those who survive are at risk of developing cerebral palsy in childhood. Recent high-quality evidence has shown that giving women magnesium sulphate immediately prior to very early birth can significantly increase the chances of their babies surviving free of cerebral palsy. In 2010 Australian and New Zealand clinical practice guidelines recommended this therapy. The WISH (Working to Improve Survival and Health for babies born very preterm) Project aims to bi-nationally improve and monitor the use of this therapy to reduce the risk of very preterm babies dying or having cerebral palsy. Methods/Design: The WISH Project is a prospective cohort study. The 25 Australian and New Zealand tertiary level maternity hospitals will be provided with a package of active implementation strategies to guide the introduction and local adaptation of guideline recommendations. Surveys will be conducted at individual hospitals to evaluate outcomes related to local implementation progress and the use and value of the WISH implementation strategies. For the hospitals participating in the ‘WISH audit of uptake and health outcomes data collection’, the primary health outcomes (assessed through case note review, and 24 month corrected age questionnaires) will be: the proportion of eligible women receiving antenatal magnesium sulphate; and rates of death prior to primary hospital discharge and cerebral palsy at two years corrected age in infants born to eligible mothers. For hospitals wishing to assess factors influencing translation locally, barriers and facilitators will be measured through interviews with health care professionals, to further guide implementation strategies. Study outcomes for the early phase of the project (Year 1) will be compared with the later intervention phase (Years 2 and 3). Discussion: The WISH Project will offer insight into the effectiveness of a multifaceted implementation strategy to improve the uptake of a novel neuroprotective therapy in obstetric clinical practice. The successful implementation of antenatal magnesium sulphate for fetal neuroprotection in Australia and New Zealand could lead to over 90 fewer very preterm babies dying or suffering the long-term consequences of cerebral palsy each year.Caroline A Crowther, Philippa F Middleton, Emily Bain, Pat Ashwood, Tanya Bubner, Vicki Flenady, Jonathan Morris, Sarah McIntyre for the WISH Project Tea

Challenges and opportunities for conducting a vaccine trial during the COVID-19 pandemic in the United Kingdom

The COVID-19 pandemic has resulted in unprecedented challenges for healthcare systems worldwide. It has also stimulated research in a wide range of areas including rapid diagnostics, novel therapeutics, use of technology to track patients and vaccine development. Here, we describe our experience of rapidly setting up and delivering a novel COVID-19 vaccine trial, using clinical and research staff and facilities in three National Health Service Trusts in Cambridgeshire, United Kingdom. We encountered and overcame a number of challenges including differences in organisational structures, research facilities available, staff experience and skills, information technology and communications infrastructure, and research training and assessment procedures. We overcame these by setting up a project team that included key members from all three organisations that met at least daily by teleconference. This group together worked to identify the best practices and procedures and to harmonise and cascade these to the wider trial team. This enabled us to set up the trial within 25 days and to recruit and vaccinate the participants within a further 23 days. The lessons learned from our experiences could be used to inform the conduct of clinical trials during a future infectious disease pandemic or public health emergency