MODELING AND SIMULATION OF LOW VOLTAGE POWER SUPPLY FOR ACTIVE PHASED ARRAY RADAR

This paper deals with the modeling and simulation of low voltage power supply (LVPS) unit to the ACTIVE PHASED ARRAY RADAR, which is used for sensing different targets at a time. This RADAR system contains flat bank of small identical antennas and huge number of transmitting and receiving modules for electronic scanning. This radar antenna requires power in different levels for various electronic devices. The proposed design of LV power supply will have the ability to manage temperature variations with high efficiency under different loading condition. The closed loop control such as voltage mode control and current mode control are used to regulate the output voltage with high switching frequency of 400khz has been designed. Simulations are performed using MATLAB / SIMULINK software

A Pilot Study to develop an Ajirna Inventory in Grahanidosha, Amlapitta and Amavata

Introduction: Impairment of Agni, can be triggered by various factors such as the consumption of heavy and dry foods, ultimately leading to Ajirna. Proper diagnosis of Ajirna and its subtypes - Amajirna, Vidagdhajirna, and Vistabdhajirna - based on classical Lakshana is often limited in practice. Digestive disorders affect millions globally, causing economic burdens through healthcare costs, work absenteeism, and reduced quality of life. Thus, this study focuses on the practical challenges faced while deriving at diagnosis of Ajirna. In this regard a series of questions based on the Lakshana play a key role in accurate differentiation of the types of Ajirna and there by forming inventory for the same. Methodology: The primary data sources included Ayurveda classical texts, contemporary books, articles, journals, and relevant web references. An Ajirna inventory is prepared by using review of Lakshana of Ajirna. Pilot study was carried out in Grahanidosha, Amlapitta, Amavata patients and findings were analysed. Results: Vidagdhajirna symptoms were predominant in Amlapitta patients, while Samanya Ajirna symptoms were moderately high in Grahani dosha patients. Amajirna symptoms were minimal in Amavata patients Discussion: The different types of Ajirna Lakshana highlight the involvement of specific Doshas and impaired Avasthapaka, leading to disrupted digestion and Dhatu nourishment

Content based image retrieval using visual geometric group19 with Jaccard similarity measure

Content-based image retrieval (CBIR) is an important research area that focuses on emerging techniques for handling large image collections and enabling efficient retrieval. The main challenge of image retrieval is to extract relevant feature vectors for image description. Therefore, visual geometric group 19 (VGG19) with Jaccard is proposed in this research for CBIR. The VGG19 allows to capture of hierarchical features, and it is appropriate for texture and fine detail characteristics. It enables to production of robust and discriminative feature representations because of numerous convolutional layers. The Jaccard is utilized as a similarity measure among feature vectors by comparing the union and intersection of feature sets. It is helpful to manage sparse and higher-dimensional data that provides a fast and accurate image retrieval process. The Caltech 256 and Corel 1K datasets are considered and it is preprocessed by image resizing and normalization. The raw images are resized to ensure dataset similarity and normalized into the range of 0 and 1. The metrics such as recall, f-measure, and average precision are used to calculate the VGG19-Jaccard performance. The VGG19-Jaccard achieves average precision of 99.0 and 99.8% for Caltech 256 and Corel 1K datasets compared to the two-stage CBIR technique

Performance Characteristics of Carbon Nanotube Field Effect Transistor based Immunosensor

Carbon nanotube biosensors are used to detect DNA and Proteins. Transistor with array of Carbon nanotubes has proved to enhance in their performance compared to that of conventional Si based. A device with array of Carbon nanotube to respond the Osteopontin (OPN) is a potential new biomarker of prostate cancer has been developed and proposed in this paper. The simulation of the biosensor is simulated using biosensor lab version-2 online through nanohub.org. The performance of the device is checked with a) settling time b) settling time and sensitivity. It is observed that the device reacts with change in time, molecule concentration, buffer-ion concentration. The settling time of the device is found to be 1 second

Water‐soluble red pigments from Isaria farinosa and structural characterization of the main colored component

International audienceThe present study describes the red pigment synthesized by the filamentous fungi Isaria farinosa under submerged culture conditions. The pigment production was optimal under the following conditions: pH 5, agitation speed 150 rpm, temperature 27 °C, incubation time 192 h, light source total darkness, sucrose and glucose as carbon source, yeast extract, meat peptone and monosodium glutamate at a fixed concentration of 3% as nitrogen source. The addition of 10 mM CaCl2 to the culture medium increased the biomass and pigment production. Structural elucidation of the pigment using gas chromatography-mass spectrometry, Fourier transform infrared spectroscopy and 1H nuclear magnetic resonance spectroscopy revealed that the red pigment contains an anthraquinone-related compound. In addition, the isolated pigment was water soluble, and was stable when exposed to salt solution (96.1% of stability after treatment with sodium chloride), acid (72.1% with citric acid), heat (86.2% at 60 °C), and sunlight (99.4%). These results are promising to further exploit the fungal culture of Isaria farinosa for producing the red pigment and, subsequently, to considerably increase its yield. The study has commercial importance in the production of Isaria farinosa pigment for industrial application after considerable toxicological examination. (© 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Concept of Deshaviparyaya w.s.r. to Migration - A Literary Review

Desha (geographical distribution) is one of the important principles linked with health of individual. The characteristics of the Desha impart certain physical, physiological, psychological attributes in inhabitants. There is another term Deshaviparyaya which is not much understood. This factor is one main cause for many diseases prevailing nowadays. A comprehensive exploration can be done between Deshaviparyaya and migration. Through a multidisciplinary lens, this work aims to provide insights into complex interplay between geographical disorientation and health effects on people’s health. Aims  & Objectives: Literary review on basic concepts of Desha & Satmya (Habituation) & understanding concepts of Deshaviparyaya in view of migration. Materials & Methods: Ayurvedic literatures containing all details about Desha, Satmya & Deshaviparyaya were studied and literary material was critically reviewed. Discussion: Effect of migration and on sleep, integumentary system and generation of stress has been discussed with its Ayurvedic treatment. Conclusion: Migration has impact on different systems of human body. This article can be hypothesized that Desha & Satmya should be considered for successful administration of therapeutics

EGFR/EGFRvIII-targeted immunotoxin therapy for the treatment of glioblastomas via convection-enhanced delivery

Glioblastoma is the most aggressive malignant brain tumor among all primary brain and central nervous system tumors. The median survival time for glioblastoma patients given the current standard of care treatment (surgery, radiation, and chemotherapy) is less than 15 months. Thus, there is an urgent need to develop more efficient therapeutics to improve the poor survival rates of patients with glioblastoma. To address this need, we have developed a novel tumor-targeted immunotoxin (IT), D2C7-(scdsFv)-PE38KDEL (D2C7-IT), by fusing the single chain variable fragment (scFv) from the D2C7 monoclonal antibody (mAb) with the Pseudomonas Exotoxin (PE38KDEL). D2C7-IT reacts with both the wild-type epidermal growth factor receptor (EGFRwt) and EGFR variant III (EGFRvIII), two onco-proteins frequently amplified or overexpressed in glioblastomas. Surface plasmon resonance and flow cytometry analyses demonstrated a significant binding capacity of D2C7-IT to both EGFRwt and EGFRvIII proteins. In vitro cytotoxicity data showed that D2C7-IT can effectively inhibit protein synthesis and kill a variety of EGFRwt-, EGFRvIII-, and both EGFRwt- and EGFRvIII-expressing glioblastoma xenograft cells and human tumor cell lines. Furthermore, D2C7-IT exhibited a robust anti-tumor efficacy in orthotopic mouse glioma models when administered via intracerebral convection-enhanced delivery (CED). A preclinical toxicity study was therefore conducted to determine the maximum tolerated dose (MTD) and no-observed-adverse-effect-level (NOAEL) of D2C7-IT via intracerebral CED for 72 hours in rats. Based on this successful rat toxicity study, an Investigational New Drug (IND) application (#116855) was approved by the Food and Drug Administration (FDA), and is now in effect for a Phase I/II D2C7-IT clinical trial (D2C7 for Adult Patients with Recurrent Malignant Glioma, https://clinicaltrials.gov/ct2/show/NCT02303678). While it is still too early to draw conclusions from the trial, results thus far are promising

Escherichia coli FtsZ molecular dynamics simulations

Earlier molecular dynamics studies of the FtsZ protein revealed that the protein has high intrinsic flexibility which the crystal structures cannot reveal. However, the input structure in these simulation studies was based on the available crystal structure data and therefore, the effect of the C-terminal Intrinsically Disordered Region (IDR) of FtsZ could not be observed in any of these studies. Recent investigations have revealed that the C-terminal IDR is crucial for FtsZ assembly in vitro and Z ring formation in vivo. Therefore, in this study, we simulated FtsZ with the IDR. Simulations of the FtsZ monomer in different nucleotide bound forms (without nucleotide, GTP, GDP) were performed. In the conformations of FtsZ monomer with GTP, GTP binds variably with the protein. Such a variable interaction with the monomer has not been observed in any previous simulation studies of FtsZ and not observed in crystal structures. We found that central helix bends towards the C-terminal domain in the GTP bound form, hence, making way for polymerization. A nucleotide dependent shift/rotation of the C-terminal domain was observed in simulation time averaged structures

Ethnobotany, Phytochemistry and Pharmacology of \u3cem\u3eMussaenda\u3c/em\u3e Species (Rubiaceae)

The genus Mussaenda is an important source of medicinal natural products, particularly iridoids, triterpenes and flavonoids. The purpose of this paper is to cover the more recent developments in the ethnobotany, pharmacology and phytochemistry of this genus. The species in which the largest number of compounds has been identified is Mussaenda pubescens. Pharmacological studies have also been made, however, of other species in this genus. These lesser known plants of the genus are described here according to their cytotoxicity, anti-inflammatory, antiviral, antioxidant and antibacterial properties. The information given here is intended to serve as a reference tool for practitioners in the fields of ethnopharmacology and natural products chemistry

Toxin-Based Targeted Therapy for Malignant Brain Tumors

Despite advances in conventional treatment modalities for malignant brain tumors—surgery, radiotherapy, and chemotherapy—the prognosis for patients with high-grade astrocytic tumor remains dismal. The highly heterogeneous and diffuse nature of astrocytic tumors calls for the development of novel therapies. Advances in genomic and proteomic research indicate that treatment of brain tumor patients can be increasingly personalized according to the characteristics of the targeted tumor and its environment. Consequently, during the last two decades, a novel class of investigative drug candidates for the treatment of central nervous system neoplasia has emerged: recombinant fusion protein conjugates armed with cytotoxic agents targeting tumor-specific antigens. The clinical applicability of the tumor-antigen-directed cytotoxic proteins as a safe and viable therapy for brain tumors is being investigated. Thus far, results from ongoing clinical trials are encouraging, as disease stabilization and patient survival prolongation have been observed in at least 109 cases. This paper summarizes the major findings pertaining to treatment with the different antiglioma cytotoxins at the preclinical and clinical stages