Ferromagnetic to spin glass cross over in (La,Tb)_{2/3}Ca_{1/3}MnO_{3}

In the series La_{2/3-x}Tb_{x}Ca_{1/3}MnO_{3}, it is known that the compositions are ferromagnetic for smaller values of x and show spin glass characteristics at larger values of x. Our studies on the magnetic properties of various compositions in the La_{2/3-x}Tb_{x}Ca_{1/3}MnO_{3} series show that the cross over from ferromagnetic to spin glass region takes place above x ~ 1/8. Also, a low temperature anomaly at 30 K, observed in the ac susceptibility curves, disappears for compositions above this critical value of x. A mixed phase region coexists in the narrow compositional range 0.1 <= x <= 0.125, indicating that the ferromagnetic to spin glass cross over is not abrupt.Comment: 5 pages, 5 figure

Scale-Out ccNUMA: Exploiting Skew with Strongly Consistent Caching

Today’s cloud based online services are underpinned by distributed key-value stores (KVS). Such KVS typically use a scale-out architecture, whereby the dataset is partitioned across a pool of servers, each holding a chunk of the dataset in memory and being responsible for serving queries against the chunk. One important performance bottleneck that a KVS design must address is the load imbalance caused by skewed popularity distributions. Despite recent work on skew mitigation, existing approaches offer only limited benefit for high-throughput in-memory KVS deployments. In this paper, we embrace popularity skew as a performance opportunity. Our insight is that aggressively caching popular items at all nodes of the KVS enables both load balance and high throughput – a combination that has eluded previous approaches. We introduce symmetric caching, wherein every server node is provisioned with a small cache that maintains the most popular objects in the dataset. To ensure consistency across the caches, we use high-throughput fully-distributed consistency protocols. A key result of this work is that strong consistency guarantees (per-key linearizability) need not compromise on performance. In a 9-node RDMA-based rack and with modest write ratios, our prototype design, dubbed ccKVS, achieves 2.2× the throughput of the state-of-the-art KVS while guaranteeing strong consistency

Induction of fibroblast senescence generates a non-fibrogenic myofibroblast phenotype that differentially impacts on cancer prognosis

Cancer-associated fibroblasts (CAF) remain a poorly characterized, heterogeneous cell population. Here we characterized two previously described tumor-promoting CAF sub-types, smooth muscle actin (SMA)-positive myofibroblasts and senescent fibroblasts, identifying a novel link between the two

The Issues and Perspectives of Pilgrimage Tourism Development in Thanjavur

Pilgrimage tourism is the type of tourism that entirely or powerfully motivates tourists for the achievement of religious attitudes and practices. One of the oldest types of visiting the attractions and a global experience in the olden times of spiritual growth, it can be differentiated into different forms. The temporary religious sightseeing is well-known by excursions to close by pilgrimage centers or religious conferences. The durable implies visits of quite a few days or weeks to nationwide and worldwide pilgrimage sites or conferences. This paper investigates the issues and challenges of pilgrimage tourism and also it’s civilizing significance in Thanjavur. The scope of socio-economic enlargement during pilgrimage tourism and analysis of the communications issues pertaining to the pilgrimage location of Thanjavur is dealt through in this study. The levels of inspiration and prospect of religious tourists are recognized as type factors in emergent pilgrimage tourism in the State. The data for this study as collected from crowd citizens occupied in pilgrimage tourism actions. The quantity of involvement of pilgrimage tourists in pilgrimage tourism development of Thanjavur is elucidated in this study. This study is generally based on primary data; secondary data necessary for this study was composed since unusual dependable sources

Supporting awareness in heterogeneous collaboration environments

Rapid technological advancements have made it possible for humans to collaborate as never before. However demands of group work necessitate distributed collaboration in very heterogeneous environments. Heterogeneity as in various applications, platforms, hardware and communication infrastructure. User mobility, lack of availability and cost often make imposing a common collaboration environment infeasible. Awareness is essential for successful collaboration. Awareness is a key design criterion in groupware but often collaboration occurs with applications not designed to support useful awareness. This dissertation deals with the issue of effective group awareness support in heterogeneous environments.;Awareness propagation is effective if the appropriate amount of information, relevant to the user\u27s sphere of activity is delivered in a timely, unobtrusive fashion. Thus issues such as information overload, and distraction have to be addressed. Furthermore ability to establish the appropriate balance between awareness and privacy is essential. Enhanced forms of awareness such as intersubjectivity and historical awareness are often invaluable. Heterogeneous environments significantly impact the above quality factors impeding effective awareness propagation. Users are unable to tailor the quality of awareness received.;Heterogeneity issues that affect awareness quality are identified. An awareness framework is proposed that binds various sources of awareness information. However for effective awareness support, physical integration must be augmented by information integration. As a solution, an awareness model is proposed. Specification of the awareness model and framework\u27s architecture and features is the key contribution. The proposed model has been validated through simulations of realistic collaboration involving human participation. Scenarios created, have tested the model\u27s usefulness in enhancing the quality of group work by propagating effective awareness among users. To accomplish the same, an Awareness Simulator application has been created. In the validation process, efforts made to create an experimental methodology revealed some techniques related to awareness evaluation in CSCW, which are proposed. Various issues required to successfully engineer such awareness frameworks are identified and their impact on requirements such as security and performance, discussed. With various standards and technologies that can be harnessed to create awareness frameworks, there is great promise that barriers in heterogeneous collaboration environments can be overcome

PILGRIMAGE TOURISM AND ITS ISSUES AND CHALLENGES WITH SPECIAL REFERENCE TO NAGAPATTINAM DISTRICT

Pilgrimage tourism is that form that is exclusively or strongly motivated for religious reasons. One of the oldest types of tourism and a worldwide phenomenon of religious history, it can be differentiated into various forms. The short-term religious tourism is distinguished by excursions to nearby pilgrimage centers or religious conferences. The long-term describes visits of several days or weeks to national and international pilgrimage sites or conferences. This paper investigates pilgrimage tourism and its issues and challenges and also it analysis the basic infrastructure issues in pilgrimage sites. .Pilgrimage tourists were identified as a key factor in developing pilgrimage tourism. The primary data for this study were collected from pilgrimage tourists which engaged in pilgrimage tourism activities. Pilgrimage tourists were identified as a key factor in developing pilgrimage tourism. This research is mainly based on primary and secondary data. Secondary data required for this study was collected from different sources. This study aims to suggest measures to make pilgrimage tourism economically viable and suggest appropriate and effective promotional strategy for promoting pilgrimage tourism inVelankanni,Nagore,Thirunallar.the analysis part includes anova,chi square,t-test,cross- tabs, Friedman mean rank test. results were shown and interpretations had written in this article. this article explains the Infrastructural facilities and pilgrimage tourism avenues in nagapattinam district

Harnessing Adeno Associated Virus (AAV) technology for the treatment of scarring

Deep skin wounds rapidly heal with scars and contractures by mobilizing extracellular matrix and cells from the fascia, deep beneath the dermal layer of the skin. Here, we demonstrate that Adeno-associated virus 8 (AAV8) is highly effective for transducing scar-forming fibroblasts in the fascia. p120 is up-regulated explicitly in scar-forming fibroblasts populations in response to injury. We demonstrate in animals that AAV8 mediated short hairpin RNA (ShRNA) silencing of p120, specifically in the fascia, reduces extracellular matrix (ECM) mobilization and enables scarless wound repair outcomes. Our findings demonstrate the potential for specifically targeting mechanisms of fascia mobilization with AAV8 vectors and the translational applications of this technology in modulating endogenous repair responses to restore the function of injured tissues in a scarless fashion

Genetic evaluation of cytochrome P450 expression in smoking and nonsmoking women

1. Regiospecific expression of CYP1A1 and CYP1B1 in human uterus of nonsmokers. The goal of this study was to investigate the expression of these isoforms in different regions of the human uterus. Expression was determined in the endometrium, endocervix and squamous (exocervix) regions from six nonsmoking women by using RT-PCR. The transcripts encoding for CYP1A1 were significantly higher (p \u3c 0.05) in the squamous (exocervix) region compared to other areas. However the expression of CYP1B1 was significantly higher (p \u3c 0.05) in the endometrium. CYP1B1 expression appeared to be extremely low in a woman in the secretory stage of the menstrual phase, relative to the endometrium of the other patients who were all in the proliferative stage at hysterectomy. It appears that variability in the expression of these isoforms may be responsible for the differential susceptibility to cancer in women.;2. Influence of menstrual phase and smoking status on expression of CYP1A1 and CYP1B1 in different regions of the uterus. The goal of this study was to investigate the expression of these isoforms in different regions of the uterus from smokers and nonsmokers. These results indicate that CYP1A1 and CYP1B1 are expressed variably in different regions of the human uterus. The expression of CYP1B1 may be susceptible both to hormonal control and cigarette smoking. The variability in the expression of these isoforms may be responsible for the differential susceptibility to cancer in some women.;3. The effect of menstrual phase on CYP3A expression in human endometrium. The CYP3A family consists of four closely related proteins. Of these, CYP3A3/4 is the most abundant P450 isoform and is responsible for metabolizing estrogen as well as a variety of therapeutic agents, whereas CYP3A7, the fetal liver form, is involved in the biosynthesis of estriol. The goal of this study was to evaluate the expression of these two major CYP3A isoforms in human uterine tissue during the proliferative (PROL) and secretory (SEC) phases of the menstrual cycle. Expression of CYP3A7 in endometrium appeared to be several fold higher (∼10-fold) in the proliferative phase compared to the secretory phase. CYP3A4 expression was comparable between the two phases of the menstrual cycle. The RTPCR results indicated differential expression of CYP3A7 in various phases of the menstrual cycle. These results indicate that CYP3A isoforms may be subject to hormonal regulation during the menstrual cycle in endometrium of premenopausal women. (Abstract shortened by UMI.)

ENVIRONMENTAL ETHICS IN PAPAL ENCYCLICALS (1981-2020)

This paper is an attempt to throw light and understand the environmental ethics mentioned in Papal Encyclicals by the different Catholic Popes according to the sign of the times between 1981 and 2020. They provide precious insights to solve many environmental problems to build up the foundations of environmental ethics. Through the encyclicals, the Popes have touched the hearts of people of various times with eco-concepts. This article exhibits the continuous and creative efforts of the Catholic Church in teaching environmental ethics to every human being who tries to exploit God’s creation due to one’s extravagant needs and greed. Thus, the Church plays a massive role to create awareness among the people of all times to respect and cherish a ‘Green world’