Hydrological conceptual model characterisation of an abandoned mine site in semiarid climate : the Sierra de Cartagena-La Unión (SE Spain)

A comprehensive study at Sierra de Cartagena-La Unión (SE Spain) abandoned mine site was carried out to characterise the regime and water quality of the groundwater system after the mine closure. The system consists of five geologic fractured blocks belonging to the Alpujarride and Nevado-Filabride complexes. The aquifer units are composed of limestone and dolostone materials. Recharge is mainly controlled by the N-130 fault system, man-made induced fractures, open-pits and underground workings. Discharge is indicated from open pit lakes by the proximal dome-shaped groundwater level contours. Aquifer natural recharge, assessed by fracture density maps and chloride mass balance, provided consistent results. The water hydrochemical facies show a marked sulphate concentration and acidic pH (average pH of 2.53-6.30). A maximum concentration of 4,100 mg/L of Zn and 40,000 mg/L of sulphate was observed in open-pit lakes. Springs present the lowest residence time and are low mineralised with an average pH of 7.6. Geochemical modelling based on the PHREEQCI code indicates water undersaturation with respect to almost all related mineral species and anoxic conditions prevail in the system. Although an adequate understanding of the regional system is provided, a further detailed hydrochemical study is necessary to assess the undergoing geochemical changes

Salud sexual y alteraciones emocionales en mujeres colombianas con cáncer de mama

Objective: Determine the effect of mood, anxiety and depression on sexual health and the impact on colombian women who have undergone treatment for breast cancer. Methods: cross-correlational design, non-probability sampling, sample 103 women undergoing treatment for breast cancer. Sexual Function Questionnaire – SFQ Karen Syrjala, 2000), Profile of mood – POMS, anxiety and depression inventory of Beck was applied. Results: The impact of treatment in breast cancer is affected by anxiety and depression experienced by women undergoing these treatments. Also, it is negatively related to sexual health in the dimensions excitement, activity, desire, satisfaction, orgasm, relationships and interest, and the mood in the vigor subscale. In contrast, the mood affects both sexual health as the impact of treatment. Conclusions: It contributes to knowledge about sexual and emotional health facing women as a result of the effects of treatments for breast cancer and provides the basis for nursing development, implementation and measurement of interventions to mitigate the impact of the treatments.Objetivo: Determinar el efecto del estado de ánimo, la ansiedad y la depresión sobre la salud sexual y el impacto en mujeres colom­bianas que han sido sometidas a tratamiento por cáncer de mama. Métodos: Diseño correlacional transver­sal, muestreo no probabilístico, muestra 103 mujeres sometidas a tratamientos por cáncer de mama. Se aplicó el cuestionario de función sexual – SFQ de Karen Syrjala, 2000), Perfil de estados de ánimo – POMS, inventario de ansiedad y depresión de Beck. Resultados: El impacto de los tratamientos en cáncer de mama se afecta por la ansiedad y la depresión que experimentan las mujeres sometidas a estos tratamientos. También, se relaciona negativamente con la salud sexual en las dimensiones excitación, actividad, de­seo, satisfacción, orgasmo, relaciones e inte­rés, y con el estado de ánimo en la subescala vigor. En contraste, el estado de ánimo afecta tanto la salud sexual como el Impacto del tratamiento. Conclusiones: Se contribuye al conoci­miento sobre la salud sexual y emocional que enfrenta la mujer como consecuencia de los efectos de los tratamientos por cáncer de mama y provee las bases a enfermería para el desarrollo, implementación y medición de intervenciones para mitigar el impacto de los tratamientos

The disease-linked Glu-26-Lys mutant version of Coronin 1A exhibits pleiotropic and pathwayspecific signaling defects

This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License.Coronin 1A (Coro1A) is involved in cytoskeletal and signaling events, including the regulation of Rac1 GTPase– and myosin II–dependent pathways. Mutations that generate truncated or unstable Coro1A proteins cause immunodeficiencies in both humans and rodents. However, in the case of the peripheral T-cell–deficient (Ptcd) mouse strain, the immunodeficiency is caused by a Glu-26-Lys mutation that targets a surface-exposed residue unlikely to affect the intramolecular architecture and stability of the protein. Here we report that this mutation induces pleiotropic effects in Coro1A protein, including the exacerbation of Coro1A-dependent actin-binding and -bundling activities; the formation of large meshworks of Coro1AE26K-decorated filaments endowed with unusual organizational, functional, and staining properties; and the elimination of Coro1A functions associated with both Rac1 and myosin II signaling. By contrast, it does not affect the ability of Coro1A to stimulate the nuclear factor of activated T-cells (NF-AT). Coro1AE26K is not a dominant-negative mutant, indicating that its pathological effects are derived from the inability to rescue the complete loss of the wild-type counterpart in cells. These results indicate that Coro1AE26K behaves as either a recessive gain-of-function or loss-of-function mutant protein, depending on signaling context and presence of the wild-type counterpart in cells.This work has been supported by grants to X.R.B. from the Castilla-León Autonomous Government (CSI101U13), the Spanish Ministry of Economy and Competitiveness (SAF2012-31371, RD12/0036/0002), the Solórzano Foundation, and the Ramón Areces Foundation. Spanish government–sponsored funding is partially supported by the European Regional Development Fund.Peer Reviewe

Participación ciudadana en el desarrollo de los planes de vivienda en Andalucía

El estallido de la burbuja inmobiliaria nos ha llevado a una crisis no solo económica, también social, se hace necesario abordar la gestión de las ciudades, y en concreto el derecho a la vivienda, desde una planificación estratégica participada que pueda incorporar a las personas y colectivos más desfavorecidos en la toma de decisiones que les afecten, desarrollando políticas públicas hacía la desmercantilización de la vivienda. La planificación de las ciudades de forma participada sigue siendo un reto de la política local. La gobernanza urbana debe desarrollar formas de organización entre administración y ciudadanía para la gestión de la cotidianidad en las ciudades. En Andalucía el Plan Municipal de Vivienda y Suelo pretende ser un instrumento para la definición y desarrollo de la política de vivienda en los municipios, estos planes deben desarrollarse con un plan de comunicación y participación que posibilite la inclusión de la ciudadanía y demás actores implicados. El presente artículo recoge el desarrollo metodológico del plan municipal participado de vivienda desarrollado en los municipios sevillanos de Bormujos y Bollulllos de la Mitación pertenecientes al área metropolitana de la ciudad. El plan participado se propone en torno a tres hitos o momentos del proceso de elaboración del Plan (inicio, diagnóstico, definición de objetivos, estrategias y líneas de acción), y en dos ámbitos: técnico-político, por una parte, y ciudadano, por otra. El artículo recoge la sistematización de las experiencias, con el propósito de servir para el debate y posible guía en la elaboración de planes municipales de vivienda participados para el desarrollo del derecho a la vivienda, como derecho human

A Study of ELL Adult’s Use of Mobile Communication Applications: an Examination of Tie Strength

This study begins to examine the problems that surround the usability and design of mobile communication applications for E.L.L (English Language Learner) immigrant adults in the United States by looking at the intent of this population when using phones. A user study was conducted where ELL immigrant adults answered questions about their mobile phone use. The results show that ELL immigrant adults use their smart phones daily and communicate with their friends and family, showing that maintenance of strong ties is important to this community. We hope this study moves towards an inclusive application that takes into account the relationship maintenance needs of this community

Participatory diagnosis for the development of municipal housing plans: The cases of Bormujos and Bollullos de la Mitación (Andalusía)

El estallido de la burbuja inmobiliaria española, en 2008, evidenció un grave problema de acceso a la vivienda para un creciente sector de la población que no puede hacer frente al precio de mercado mientras parte del parque residencial existente queda vacante. En un contexto de escasez de recursos, el Plan Andaluz de Vivienda y Suelo (2016-2020) plantea que sean los municipios los que, elaborando Planes Municipales de Vivienda y Suelo (PMVS), exploren soluciones innovadoras que contribuyan a acercar estos dos extremos, desde el conocimiento de la situación concreta de cada localidad y la implicación de los actores sociales involucrados. El presente artículo propone construir un diagnóstico participado de la situación de demanda insatisfecha y parque vacante a escala local, desde el cual situar los retos a los que un PMVS debe dar respuesta. Para ello, y bajo un marco metodológico propio de la Investigación-Acción-Participativa, se analiza el proceso participativo puesto en marcha en dos municipios del área metropolitana de Sevilla, Bormujos y Bollullos de la Mitación, como casos de estudio representativos de los procesos urbanísticos e inmobiliarios sufridos durante los años de boom inmobiliario. Los resultados consensuados permiten dibujar un perfil de las necesidades existentes y los recursos disponibles que se podrían destinar a satisfacerlas, en este caso vivienda vacía y suelos ociosos. A su vez, la experiencia desarrollada permite concluir cómo la participación de técnicos, políticos y ciudadanos en un proceso de elaboración de políticas públicas favorece el desarrollo de conciencia crítica, sentido de apropiación y compromiso de los agentes locales con el reto a afrontar, lo que facilita su posterior implicación en la implementación de acciones colaborativas.The bursting of the Spanish real estate bubble in 2008 revealed a serious problem of housing access for a growing sector of the population that cannot afford market prices, while part of the existing housing stock remains vacant. In a context of lack of resources, the Andalusian Housing and Land Plan (2016-2020) proposes that municipalities develop Municipal Housing and Land Plans (known as PMVS in Spanish) to explore innovative solutions that contribute to bringing these two extremes closer together based on knowledge of the specific situation in each locality and the participation of the social actors involved. This article sets out to create a participatory diagnostic of the situation of unresolved demand and vacant housing stock on a local scale in order to situate the challenges that a PMVS should address. To this end, under a methodological framework of participatory action research, the study analyses the participatory process implemented in two municipalities in the Seville metropolitan area, Bormujos and Bollullos de la Mitación, as case studies representative of the urban processes that took place during the years of the real estate bubble. Therefore, the results were used to create a profile of the existing needs and the available resources that could be allocated to meet them, in this case empty housing and vacant land. Likewise, through this experience it was possible to conclude how the participation of technicians, politicians and citizens in public policy development contributes to building critical awareness, a sense of appropriation and the commitment of local agents to the challenge faced, which facilitates their subsequent involvement in the implementation of collaborative actions

Co Treatment With Biologic Agents and Immunotherapy in the Setting of irAEs of Difficult Management

Adverse drugs reaction; Immune check-point inhibitors therapy; Immunosuppression therapyReacción adversa a medicamentos; Terapia con inhibidores del punto de control inmunitario; Terapia inmunosupresoraReaccions adverses als fàrmacs; Teràpia amb inhibidors del punt de control immune; Teràpia d'immunosupressióIn recent years, immunotherapy has become an important pillar of cancer treatment, with high response rates regardless of tumor histology or baseline mutations, sometime in patients without any alternative of treatment. Moreover, these treatments are moving from later line therapies to front-line therapies in the metastasic setting. However, immune activation associated with immune check-point inhibitors (ICI) is not selective and a large variety of immune-related adverse events, with an increasing frequency, have been associated with anti-PD1, anti-PD-1/L-1 and anti-CTLA-4 agents. In clinical trials, and sometimes also in real life practice, patients who develop severe toxicities on ICI-based therapies are usually not allowed to resume ICI once their disease progresses, because of the chance of developing severe irAEs on rechallenge with immunotherapies. Moreover, patients with irAEs suffer important side effects due to the high dose corticosteroids that are used to treat them. Therapy with ICI is sometimes the only alternative for certain patients, and for this reason co treatment with classic (DMARDS) or biologic immunosuppression therapy and ICI must be considered. Co-treatment with this type of immunosuppressant drugs, apart from allowing the maintenance of ICI therapy, drive to a lesser use of corticosteroids, with an improvement of the safety and quality of life of the patients. Such a tailored scheme of treatment is mostly an expert opinion based on recommendation and currently there is scarce evidence supporting it. Herein we present comprehensive, current recommendations and real-world data on the use of co-treatment with ICI and DMARDS and biologic immunosuppression

Incidencia de violencia contra la mujer y su vínculo al delito de feminicidio dentro del distrito judicial de Ica, 2021

La presente investigación tuvo como objetivo establecer la relación de la incidencia de violencia contra la mujer y su vínculo al delito de feminicidio dentro del distrito judicial de Ica, 2021. La metodología utilizada fue de tipo básico, enfoque cuantitativo, alcance correlacional, diseño no experimental y análisis transversal-correlacional, con una muestra de 80 abogados agremiados en actividad del Colegio de Abogados de Ica, muestreo no probabilístico, se utilizó la técnica de la encuesta, el instrumento fue un cuestionario aplicado vía el formulario del Google Form. Para analizar los resultados obtenidos se aplicó el software estadístico SPSSv.25 los cuales fueron, el 48,8% es regular la incidencia entre las variables y su correlación (Rho=0.551 y p=0.000<0.05), mientras que el 48,8% de los factores de riesgo es regular la incidencia en la violencia y feminicidio con una correlación (Rho=0.516 y p=0.000<0.05) y el 43,8% de los factores socio-culturales es regular con una correlación (Rho=0.425 y p=0.000<0.05). Concluyendo que existe una moderada relación de incidencia de violencia contra la mujer y su vínculo al delito de feminicidio dentro del distrito Judicial de Ica, 2021

Burr detection and classification using RUSTICO and image processing

.Machined workpieces must satisfy quality standards such as avoid the presence of burrs in edge finishing to reduce production costs and time. In this work we consider three types of burr that are determined by the distribution of the edge shape on a microscopic scale: knife-type (without imperfections), saw-type (presence of small splinters that could be accepted) and burr-breakage (substantial deformation that produces unusable workpieces). The proposed method includes RUSTICO to classify automatically the edge of each piece according to its burr type. Experimental results validate its effectiveness, yielding a 91.2% F1-Score and identifying completely the burr-breakage type.S

Disability Policies and Management in Bolivia: Changes and Challenges

The Plurinational State of Bolivia has experienced significant social changes with a growing commitment toward policies that favor vulnerable populations. Acknowledging movements led by people with disabilities to promote progress in social policies is a crucial task. The public sector has responded to the demands and needs of this population through recognition and promotion of their rights. Nevertheless, to ensure progress, we must support the voices of the stakeholders and promote their participation in identifying the strengths and weaknesses of the system, and the real needs and demands of people with disabilities in Bolivia. To this end, in this study, we gathered statements of key informants, using a focus group technique. The results of the data analysis indicate an increase in social awareness and recognition of the needs of this collective and the importance of their full inclusion in society. However, there is a distortion in the application of certain assistance and inclusion policies in favor of people with disabilities because these policies do not have their intended impact.Resultados fruto de un proyecto financiado por la Agencia Andaluza de Cooperación Internacional para el Desarrollo (AACID) de la Junta de Andalucía