Smart thinking on co-creation and engagement: Searchlight on underground built heritage

This paper aims to explore public participation for activating underground built heritage (UBH). It describes and analyses practices of stakeholders’ engagement in different UBH assets, based on experiences gathered in the scope of the European COST Action ‘Underground4value’. It brings together five inspiring cases from Italy, Portugal, Spain, Switzerland and the United Kingdom, in which digital and mobile technologies were used as tools to improve community experiences in UBH. Thus, the paper discusses ‘smartness’ from the perspective of people and communities around cultural assets, where ‘smartness’ becomes a new connotation and a pathway to advance (local) knowledge and know-how. Therefore, this paper takes on the challenge to define a smart city as an ecosystem for people’s empowerment and participation, and, in particular, to explore social tools for creating new values in heritage placemaking—where sharing knowledge becomes a fundamental principle.info:eu-repo/semantics/publishedVersio

Long-term complete remission in a patient with high-risk primary mediastinal B-cell lymphoma and iatrogenic symptomatic bradycardia after only two courses of DA-EPOCH-R followed by chemo-free treatment

: Most patients with Primary Mediastinal B-Cell Lymphoma (PMBCL) are cured by rituximab and doxorubicin-based immunochemotherapy, with or without radiotherapy. In cases with relapsed and refractory (RR) disease the prognosis was historically poor. Recently, immune checkpoint-based strategies have been shown to be highly effective in patients with RR-PMBCL. We report the case of a 23-year-old woman who, due to recurring episodes of symptomatic chemotherapy-induced sinus bradycardia, was unable to receive the planned six courses of immunochemotherapy, mediastinal radiotherapy, and autologous transplantation, leading to the early initiation of a chemo-free strategy. The patient maintains a continuous complete remission at a four-year follow-up after only two cycles of immunochemotherapy followed by nivolumab plus brentuximab vedotin (BV) and pembrolizumab consolidation. Beyond describing an underreported complication of anticancer treatments, the favorable clinical outcome suggests that in PMBCL, a minimal load of chemotherapy, integrated by early PD-1 blockade, with or without BV, may be sufficient to achieve long-term disease control and cure at least in some patients

Long-term efficacy and safety of dose-dense and dose-intense ABVD without consolidation radiotherapy in patients with advanced Hodgkin lymphoma: A 15-year follow-up of the ABVDDD-DI phase II study

: We demonstrated that dose-densified and dose-intensified ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine; ABVDDD-DI) was safe and effective. Here, we present a post hoc long-term analysis of the 82 patients enrolled in the original study. The median observation time was 175 months (IQR 159-197). At 15 years, progression-free and overall survival rates were 81.2% (95% CI, 69.9%-88.7%) and 92.7% (95% CI, 82.6%-97.0%), respectively. Four patients with multiple cardiovascular risk factors experienced delayed G3 cardiac events. The cumulative incidence of second malignancies at 20 years was 6.1%. Fertility and childbearing potential were unaffected. Data support an ongoing benefit for ABVDDD-DI without uneven late toxicities

Imaging of the Inner Zone of Blast Furnaces Using MuonRadiography: The BLEMAB Project

The aim of the BLEMAB project (BLast furnace stack density Estimation through online Muons ABsorption measurements) is the application of muon radiography techniques, to image a blast furnace’s inner zone. In particular, the goal of the study is to characterize the geometry and size of the so-called “cohesive zone”, i.e., the spatial region where the slowly downward-moving material begins to soften and melt, which plays such an important role in the performance of the blast furnace itself. Thanks to the high penetration power of natural cosmic-ray muon radiation, muon transmission radiography could be an appropriate non invasive methodology for the imaging of large high-density structures such as a blast furnace, whose linear dimensions can be up to a few tens of meters. A state-of-the-art muon tracking system is currently in development and will be installed at a blast furnace on the ArcelorMittal site in Bremen (Germany), where it will collect data for a period of various months. In this paper, the status of the project and the expectations based on preliminary simulations are presented and briefly discussed

The BLEMAB European project: Muon radiography as an imaging tool in the industrial field

The European project called BLEMAB (BLast furnace stack density Estimation through on-line Muons ABsorption measurements), provides for the application of the muon radiography technique in the industrial environment. The project represents a non-invasive way of monitoring a blast furnace and in particular aims to study the geometric and density development of the so-called “cohesive zone”, which is important for the performance of the blast furnace itself. The installation of the detectors is expected in 2022 at the ArcelorMittal site in Bremen (Germany). This paper describes the status of the project, the experimental setup and the first results obtained with preliminary simulations. © 2022 Societa Italiana di Fisica. All rights reserved

Exploring the potential of muon radiography for blast furnace assessments: advancements in non-invasive imaging and structural analysis

The BLEMAB European project (BLast furnace stack density Estimation through online Muon ABsorption measurements), the evolution of the previous Mu-Blast European project, is designed to investigate in detail the capability of muon radiography techniques applied to the imaging of the inner zone of a blast furnace. In particular, the goal of this collaboration is to characterize the internal region (so-called cohesive zone) where the slowly downward-moving material begins to soften and melt, which plays an important role in the performance of the blast furnace itself. In this contribution, we describe the state-of-the-art of the muon tracking system which is currently being developed and installed at a blast furnace on the ArcelorMittal site in Bremen (Germany). Moreover, we will present the GEANT4 simulation framework devised for this application together with the simulation results. Finally, we will show the possible contribution of multiple scattering effects to such peculiar applications

Retention of chromium by modified Al-Bentonite Retenção de cromo por Al-bentonita modificada

Retention of chromium (III) from a tanning wastewater by modified Al-bentonites was studied. One bentonite from San Juan province, Argentina, was used. Al-bentonite was prepared by contact of bentonite with hydrolyzed OH-Al solutions (0.10 M in Al) for 24 hours. The modified Al-bentonites were obtained by: a) treatment with 0.5 M sodium chloride; b) with 0.5 M sodium chloride adjusted at pH 8; and c) treatment with an hexametaphosphate solution after sodium addition. Then, the samples were dried at 100 °C and heated at 500 °C. The chromium (III) retention by samples was carried out in batch system putting in contact the material with a 2000 ppm Cr tannery waste at different times. The retained chromium was characterized by analyzing the supernatant using UV-visible spectroscopy. The different chromium retention was correlated with structural characteristics of the solids.<br>Foi estudada a retenção de cromo (III) de águas residuais por meio de Al-bentonitas modificadas. Foi usada uma bentonita da província de San Juan, Argentina. As bentonitas-Al forma preparadas colocando-as em contato com soluções (0,10 M Al) hydrolizadas de OH-Al durante 24 horas. As bentonitas-Al modidicadas foram obtidas por meio de: a) tratamento com cloreto de sódio 0,5 M; b) com cloreto de sódio 0,5 M sodium com pH ajustado para 8; e c) tratamento com uma solução de hexametafosfato após a adição de sódio. As amostras foram então secas a 100 °C e aquecidas a 500 °C. A retenção do cromo (III) pelas amostras foi feita em lotes colocando o material em contato em diferentes tempos com um resíduo contendo 2000 ppm de cromo. O cromo retido foi caracterizado por meio de análise do sobrenadante usando espectroscopia UV-visível. As diferentes retenções de cromo foram correlacionadas com características estruturais dos sólidos