The Effect of FDI on Child Labor

This paper examines the extent to which foreign direct investment (FDI) affects child labor. Using 1995 data for 145 countries, we find that, contrary to common fears, FDI is negatively correlated with child labor. This effect, however, disappears when controlling for per capita income. After doing so, we find no robust effect of either FDI or international trade on child labor. This result is robust to corrections for the endogeneity of FDI, trade, and income. Furthermore, this result is confirmed when using data from earlier years and when using fixed effects. This suggests that the impact of FDI and trade on child labor, if any, is the increases in income they generate.Child Labor, Foreign Direct Investment, International Trade

A Wire Position Monitor System for the 1.3 GHZ Tesla-Style Cryomodule at the Fermilab New-Muon-Lab Accelerator

The first cryomodule for the beam test facility at the Fermilab New-Muon-Lab building is currently under RF commissioning. Among other diagnostics systems, the transverse position of the helium gas return pipe with the connected 1.3 GHz SRF accelerating cavities is measured along the ~15 m long module using a stretched-wire position monitoring system. An overview of the wire position monitor system technology is given, along with preliminary results taken at the initial module cool down, and during further testing. As the measurement system offers a high resolution, we also discuss options for use as a vibration detector.Comment: 4 pp. 15th International Conference on RF Superconductivity (SRF2011). 25-29 Jul 2011. Chicago, Illinois, US

High Resolution BPM Upgrade for the ATF Damping Ring at KEK

A beam position monitor (BPM) upgrade at the KEK Accelerator Test Facility (ATF) damping ring has been accomplished, carried out by a KEK/FNAL/SLAC collaboration under the umbrella of the global ILC R&D effort. The upgrade consists of a high resolution, high reproducibility read-out system, based on analog and processing, and also implements a new automatic gain error correction schema. The technical concept and realization as well as results of beam studies are presented.Comment: 3 pp. 10th European Workshop on Beam Diagnostics and Instrumentation for Particle Accelerators DIPAC 2011, 16-18 May 2011. Hamburg, German

Tevatron Beam Position Monitor Upgrade

This paper describes the development of a digital-based Beam Position System which was designed, developed, and adapted for the Tevatron during Collider Run II.Comment: 20 p

Critical role of phosphorylation of serine 165 of YBX1 on the activation of NF- B in colon cancer

poster abstractY-box binding protein 1 (YBX1) is a multifunctional protein known to facilitate many of the hallmarks of cancer. Elevated levels of YBX1 protein are highly correlated with cancer progression, making it an excellent marker in cancer. The connection between YBX1 and the important nuclear factor B (NF-B), has never been previously reported. Here, we show that overexpression of wild type YBX1 (wtYBX1) activates NF-B, suggesting that YBX1 is a potential NF-B activator. Furthermore, using mass spectrometry analysis, we identified novel phosphorylation of serine 165 (S165) on YBX1. Overexpression of the S165A-YBX1 mutant in either 293 cells or colon cancer HT29 cells showed dramatically reduced NF-B activating ability as compared to that of wtYBX1, confirming that S165 phosphorylation is critical for the activation of NF-B by YBX1. We further show that expression of the S165A-YBX1 mutant dramatically decreased the expression of NF-B-inducible genes, reduced cell growth, and compromised tumorigenic ability as compared to wtYBX1. Taken together, we provide the first evidence that YBX1 functions as a tumor promoter via NF-B activation, and phosphorylation of S165 of YBX1 is critical for this function. Therefore, our important discovery may lead to blocking S165 phosphorylation as a potential therapeutic strategy to treat colon cancer

Role of Novel Serine 316 Phosphorylation of the p65 Subunit of NF-κB in Differential Gene Regulation

Nuclear factor κB (NF-κB) is a central coordinator in immune and inflammatory responses. Constitutive NF-κB is often found in some types of cancers, contributing to oncogenesis and tumor progression. Therefore, knowing how NF-κB is regulated is important for its therapeutic control. Post-translational modification of the p65 subunit of NF-κB is a well known approach for its regulation. Here, we reported that in response to interleukin 1β, the p65 subunit of NF-κB is phosphorylated on the novel serine 316. Overexpression of S316A (serine 316 → alanine) mutant exhibited significantly reduced ability to activate NF-κB and decreased cell growth as compared with wtp65 (wild type p65). Moreover, conditioned media from cells expressing the S316A-p65 mutant had a considerably lower ability to induce NF-κB than that of wtp65. Our data suggested that phosphorylation of p65 on Ser-316 controls the activity and function of NF-κB. Importantly, we found that phosphorylation at the novel Ser-316 site and other two known phosphorylation sites, Ser-529 and Ser-536, either individually or cooperatively, regulated distinct groups of NF-κB-dependent genes, suggesting the unique role of each individual phosphorylation site on NF-κB-dependent gene regulation. Our novel findings provide an important piece of evidence regarding differential regulation of NF-κB-dependent genes through phosphorylation of different p65 serine residues, thus shedding light on novel mechanisms for the pathway-specific control of NF-κB. This knowledge is key to develop strategies for prevention and treatment of constitutive NF-κB-driven inflammatory diseases and cancers

Strict Photo ID, Voter Turnout, and Race

Everett Dirksen, the senator who introduced the Voting Rights Act, once said: the right of a free citizen to vote is somehow a battle that is never quite fully won in any time or generation. So far, he seems to have been right. In recent years, a push across many states to enact stricter voter identification laws has received widespread attention. This issue and its ramifications are often discussed in the media, but without much empirical evidence. In 2007, Alvarez, Bailey and Katz assembled a working paper titled The Effect of Voter Identification Laws on Turnout, which was recently referenced in the federal case between Texas and the Justice Department over whether the state\u27s new voter ID law was in violation of the 1965 Voting Rights Act. This paper, the only piece of social science evidence the Judges gave significant consideration to in the Texas case, is the basis for mine. I use a similar methodology, but update my data to include survey results from the 2008 and 2010 elections, and focus only on strict photo ID laws rather than every category of voter identification. The results are astounding: a state enacting a strict photo ID voting requirement is associated with a white citizen being 7% less likely to vote, and a Hispanic citizen being 27% less likely to vote. I believe this disparate effect across both ethnicity and language group shows that strict photo ID laws are in effect in violation of the Voting Rights Act

The Locked Gates to Tension City: The Commission on Presidential Debates, the FEC, and the Two-Party System

Since John F. Kennedy and Richard Nixon walked into a Chicago television studio for the first general election presidential debate in 1960, candidate debates have been a fundamental aspect of presidential campaigns and have had broader effects on society at large. The Commission on Presidential Debates (“CPD”) has been in charge of organizing the general election debates since it was created in 1987 by the Democratic and Republican parties. In its tenure, the CPD has restricted its massive platform almost every election to the Republican and Democratic candidates through the use of criteria that seemingly follow the law’s requirement of being pre-established and objective. But the CPD’s criteria is neither truly objective nor nonpartisan; it is effectively bipartisan. By ignoring and dismissing complaints about the CPD’s exclusion of third-party and independent presidential candidates, the Federal Election Commission (“FEC”), which is itself based on a bipartisan structure, reinforces the power of the partisan duopoly in American presidential elections. There is a strong argument that the FEC should hold the CPD to the legal requirement of non-partisan access to is debates. The spirit of the law points in this direction. But in this, the law is wrong. Rather than commit to the pretense of entirely open access in the elections, the FEC should revise its regulations to reflect the reality: American politics is run through a two-party system

Novel Serine 176 Phosphorylation of YBX1 Activates NF-κB in Colon Cancer

Y box protein 1 (YBX1) is a well known oncoprotein that has tumor-promoting functions. YBX1 is widely considered to be an attractive therapeutic target in cancer. To develop novel therapeutics to target YBX1, it is of great importance to understand how YBX1 is finely regulated in cancer. Previously, we have shown that YBX1 could function as a tumor promoter through phosphorylation of its Ser-165 residue, leading to the activation of the NF-κB signaling pathway (1). In this study, using mass spectrometry analysis, we discovered a distinct phosphorylation site, Ser-176, on YBX1. Overexpression of the YBX1-S176A (serine-to-alanine) mutant in either HEK293 cells or colon cancer HT29 cells showed dramatically reduced NF-κB-activating ability compared with that of WT-YBX1, confirming that Ser-176 phosphorylation is critical for the activation of NF-κB by YBX1. Importantly, the mutant of Ser-176 and the previously reported Ser-165 sites regulate distinct groups of NF-κB target genes, suggesting the unique and irreplaceable function of each of these two phosphorylated serine residues. Our important findings could provide a novel cancer therapy strategy by blocking either Ser-176 or Ser-165 phosphorylation or both of YBX1 in colon cancer