Acoustic Communication at the Water's Edge: Evolutionary Insights from a Mudskipper

Coupled behavioural observations and acoustical recordings of aggressive dyadic contests showed that the mudskipper Periophthalmodon septemradiatus communicates acoustically while out of water. An analysis of intraspecific variability showed that specific acoustic components may act as tags for individual recognition, further supporting the sounds' communicative value. A correlative analysis amongst acoustical properties and video-acoustical recordings in slow-motion supported first hypotheses on the emission mechanism. Acoustic transmission through the wet exposed substrate was also discussed. These observations were used to support an “exaptation hypothesis”, i.e. the maintenance of key adaptations during the first stages of water-to-land vertebrate eco-evolutionary transitions (based on eco-evolutionary and palaeontological considerations), through a comparative bioacoustic analysis of aquatic and semiterrestrial gobiid taxa. In fact, a remarkable similarity was found between mudskipper vocalisations and those emitted by gobioids and other soniferous benthonic fishes

Derivation of lithofacies from geophysical logs : a review of methods from manual picking to machine learning

The aims of this report are to document: 1. A range of methods that are currently used by the BGS stratigraphers to extract lithological information from geophysical logs (includes manual classification, cut-off analysis, mineral composition by linear inversion). 2. Alternative methods which, at present, are not routinely applied but are sufficiently practical and accessible that they could become important, including unsupervised (k-mean clustering) and supervised machine learning approaches. The report does not aim or claim to be a complete inventory of all possible methods to derive lithological information from geophysical logs. The authors welcome correspondence and information on any additional methods that are available or emerging

Potential interference of aluminum chlorohydrate with estrogen receptor signaling in breast cancer cells

Aluminum salts are widely used as the active antiperspirant in underarm cosmetic. Experimental observations indicate that its long term application may correlate with breast cancer development and progression. This action is proposed to be attributed, among others, to aluminum possible estrogen-like activities. In this study we showed that aluminum, in the form of aluminum chlorohydrate (ACH), caused increase in estrogen receptor alpha (ERα) protein levels, in ERα-positive MCF-7 cells. This effect was accompanied by moderate activation of Estrogen Response Elements (ERE)-driven reporter gene expression and 20%-50% increase in certain estrogen responsive, ERE-independent genes expression. Genes affected were ERα, p53, cyclin D1, and c-fos, crucial regulators of breast cancer development and progression. ACH-induced genes expression was eliminated in the presence of the estrogen antagonist: ICI 182780, in MCF-7 cells, whereas it was not observed in ERα-negative MDA-MB-231 breast cancer cells, indicating aluminum interference with estrogen signaling. Moreover, ACH caused increase in the perinuclear localization of estrogen receptor alpha in MCF-7 breast cancer cells and increase in the mitochondrial Bcl-2 protein, possibly affecting receptors-mediated mitochondrial actions and mitochondrial-dependent apoptosis. ACH-induced perinuclear localization of estrogen receptor beta was also observed in MDA-MB-231. Our findings indicate that aluminum actions on estrogen receptors protein level and subcellular localization possibly affect receptors-mediated actions and thus, aluminum interference with estrogen signaling

An automated methodology for converting OSM data into a Land Use/Cover map

Land Use/Land Cover Maps (LULCM), fundamental for many areas of application, are usually generated through the classification of satellite imagery. However, their creation is time consuming and therefore updated LULCM are seldom available. The OpenStreetMap (OSM) collaborative project collects a rich set of vector data provided by volunteers at a global scale. It has already been shown that OSM data may be converted into LULCM, but data quality issues in OSM raise some challenges for this conversion, such as overlapping features that should be assigned to different classes. Thus, the creation of LULCM using OSM requires a solution for handling these inconsistencies. In this article an automated methodology is proposed using rules of decision and spatial analysis in a GIS environment to convert OSM features into LULCM, which automatically solves the inconsistencies mentioned above. The methodology is applied to two areas in Europe and the results are compared to available LULCM

An automated methodology for converting OSM data into a Land Use/Cover map

Land Use/Land Cover Maps (LULCM), fundamental for many areas of application, are usually generated through the classification of satellite imagery. However, their creation is time consuming and therefore updated LULCM are seldom available. The OpenStreetMap (OSM) collaborative project collects a rich set of vector data provided by volunteers at a global scale. It has already been shown that OSM data may be converted into LULCM, but data quality issues in OSM raise some challenges for this conversion, such as overlapping features that should be assigned to different classes. Thus, the creation of LULCM using OSM requires a solution for handling these inconsistencies. In this article an automated methodology is proposed using rules of decision and spatial analysis in a GIS environment to convert OSM features into LULCM, which automatically solves the inconsistencies mentioned above. The methodology is applied to two areas in Europe and the results are compared to available LULCM

The triterpene echinocystic acid and its 3-O-glucoside derivative are revealed as potent and selective glucocorticoid receptor agonists

Glucocorticoids are steroid hormones widely used to control many inflammatory conditions. These effects are primarily attributed to glucocorticoid receptor transrepressional activities but with concomitant receptor transactivation associated with considerable side effects. Accordingly, there is an immediate need for selective glucocorticoid receptor agonists able to dissociate transactivation from transrepression. Triterpenoids have structural similarities with glucocorticoids and exhibit anti-inflammatory and apoptotic activities via mechanisms that are not well-defined. In this study, we examined whether echinocystic acid and its 3-O-glucoside derivative act, at least in part, through the regulation of glucocorticoid receptor and whether they can constitute selective receptor activators. We showed that echinocystic acid and its glucoside induced glucocorticoid receptor nuclear translocation by 75% and 55%. They suppressed the nuclear factor-kappa beta transcriptional activity by 20% and 70%, respectively, whereas they have no glucocorticoid receptor transactivation capability and stimulatory effect on the expression of the phosphoenolopyruvate carboxykinase target gene in HeLa cells. Interestingly, their suppressive effect is diminished in glucocorticoid receptor low level COS-7 cells, verifying the receptor involvement in this process. Induced fit docking calculations predicted favorable binding in the ligand binding domain and structural characteristics which can be considered consistent with the experimental observations. Further, glucocorticoids exert apoptotic activities; we have demonstrated here that the echinocystic acids in combination with the synthetic glucocorticoid, dexamethasone, induce apoptosis. Taken together, our results indicate that echinocystic acids are potent glucocorticoid receptor regulators with selective transrepressional activities (dissociated from transactivation), highlighting the potential of echinocystic acid derivatives as more promising treatments for inflammatory conditions

Mesh Rectopexy or Resection Rectopexy for Rectal Prolapse; Is There a Gold Standard Method: A Systematic Review, Meta-Analysis and Trial Sequential Analysis

(1) Background: Rectal prolapse is a benign condition that mainly affects females and the elderly. The most common symptoms are constipation and incontinence. The treatment of choice is surgical, but so far, there has been no gold standard method. The aim of this study is to compare the two most common intrabdominal procedures utilized for treating rectal prolapse: the resection rectopexy and the mesh rectopexy. (2) Methods: In this study, we conducted a thorough systematic review and meta-analysis of the available literature and compared the two different approaches regarding their complication rate, recurrence rate, and improvement of symptoms rate. (3) Results: No statistically significant difference between the two methods was found regarding the operating time, the length of stay, the overall complication rate, the surgical site infection rate, the cardiopulmonary complication rate, the improvement in constipation and incontinence rates, and the recurrence rate. (4) Conclusions: Our study revealed that mesh rectopexy and resection rectopexy for rectal prolapse have similar short- and long-term outcomes. As a result, the decision for the procedure used should be individualized and based on the surgeon’s preference and expertise