Illinois least-cost sewer system design model: ILSD-1 & 2 user’s guide

ILSD models are sewer system models for least-cost optimal design of the entire system. ILSD-1 designs for a specified layout the size and slope of the sewers with or without detention storages with user supplied rainfall and/or inlet hydrographs. ILSD-2 is similar to ILSD-1 but also with risk consideration; i.e., with the risk damage cost included in the optimization procedure and a risk equation supplied by the user. The user may choose either ILSD-1 or 2 as he (she) wishes and according to the available data. This user's guide provides the necessary information to use the computer program. Data preparation for various options to fit different engineering situations is presented.U.S. Department of the InteriorU.S. Geological SurveyOpe

Extrinsic Fluorescent Dyes as Tools for Protein Characterization

Noncovalent, extrinsic fluorescent dyes are applied in various fields of protein analysis, e.g. to characterize folding intermediates, measure surface hydrophobicity, and detect aggregation or fibrillation. The main underlying mechanisms, which explain the fluorescence properties of many extrinsic dyes, are solvent relaxation processes and (twisted) intramolecular charge transfer reactions, which are affected by the environment and by interactions of the dyes with proteins. In recent time, the use of extrinsic fluorescent dyes such as ANS, Bis-ANS, Nile Red, Thioflavin T and others has increased, because of their versatility, sensitivity and suitability for high-throughput screening. The intention of this review is to give an overview of available extrinsic dyes, explain their spectral properties, and show illustrative examples of their various applications in protein characterization

Plasma physics and control studies planned in JT-60SA for ITER and DEMO operations and risk mitigation

| openaire: EC/H2020/633053/EU//EUROfusionA large superconducting machine, JT-60SA has been constructed to provide major contributions to the ITER program and DEMO design. For the success of the ITER project and fusion reactor, understanding and development of plasma controllability in ITER and DEMO relevant higher beta regimes are essential. JT-60SA has focused the program on the plasma controllability for scenario development and risk mitigation in ITER as well as on investigating DEMO relevant regimes. This paper summarizes the high research priorities and strategy for the JT-60SA project. Recent works on simulation studies to prepare the plasma physics and control experiments are presented, such as plasma breakdown and equilibrium controls, hybrid and steady-state scenario development, and risk mitigation techniques. Contributions of JT-60SA to ITER and DEMO have been clarified through those studies.Peer reviewe