An Inverse Geometry Problem for the Localization of Skin Tumours by Thermal Analysis

In this paper, the Dual Reciprocity Method (DRM) is coupled to a Genetic Algorithm (GA) in an inverse procedure through which the size and location of a skin tumour may be obtained from temperature measurements at the skin surface. The GA is an evolutionary process which does not require the calculation of sensitivities, search directions or the definition of initial guesses. The DRM in this case requires no internal nodes. It is also shown that the DRM approximation function used is not an important factor for the problem considered here. Results are presented for tumours of different sizes and positions in relation to the skin surface

Algorithms versus architectures for computational chemistry

The algorithms employed are computationally intensive and, as a result, increased performance (both algorithmic and architectural) is required to improve accuracy and to treat larger molecular systems. Several benchmark quantum chemistry codes are examined on a variety of architectures. While these codes are only a small portion of a typical quantum chemistry library, they illustrate many of the computationally intensive kernels and data manipulation requirements of some applications. Furthermore, understanding the performance of the existing algorithm on present and proposed supercomputers serves as a guide for future programs and algorithm development. The algorithms investigated are: (1) a sparse symmetric matrix vector product; (2) a four index integral transformation; and (3) the calculation of diatomic two electron Slater integrals. The vectorization strategies are examined for these algorithms for both the Cyber 205 and Cray XMP. In addition, multiprocessor implementations of the algorithms are looked at on the Cray XMP and on the MIT static data flow machine proposed by DENNIS

Dissolved oxygen sensing using an optical fibre long period grating coated with hemoglobin

A long period grating fiber optic sensor coated with hemoglobin is used to detect dissolved oxygen. The sensitivity of this sensor to the ratio of dissolved carbon dioxide to dissolved oxygen is demonstrated via the conversion of carboxyhemoglobin to oxyhemoglobin on the sensor surface. The sensor shows good repeatability with a %CV of less than 1% for carboxyhemoglobin and oxyhemoglobin states with no measurable drift or hysteresis

Overwrite fabrication and tuning of long period gratings

The central wavelengths of the resonance bands are critical aspect of the performance of long period gratings (LPGs) as sensors, particularly for devices designed to operate near the phase matching turning point (PMTP), where the sensitivity to measurements can vary rapidly. Generally, LPGs are characterized by their period, but the amplitude of the amplitude of the index modulation is also an important factor in determining the wavelengths of the resonance bands. Variations in fabrication between LPG sensors can increase or decrease the sensitivity of the LPG to strain, temperature or surrounding refractive index. Here, the technique of overwritten UV laser fabrication is demonstrated. It is shown that, on repeated overwriting, the resonance bands of an LPG exhibit significant wavelength shift, which can be monitored and which can be used to tune the resonance bands to the desired wavelengths. This technique is applied to periods in the range 100 to 200 µm, showing the cycle-to-cycle evolution of the resonance bands near the PMTPs of a number of cladding modes. The use of online monitoring is shown to reduce the resonance band sensor-to-sensor central wavelength variation from 10 nm to 3 nm

A coupled dual reciprocity BEM/Genetic algorithm for identification of blood perfusion parameters

The paper presents an inverse analysis procedure based on a coupled numerical formulation through which the coefficients describing non-linear thermal properties of blood perfusion may be identified. The numerical technique involves a combination of the Dual Reciprocity Boundary Element Method and a Genetic Algorithm for the solution of the Pennes bioheat equation. Both linear and quadratic temperature-dependent variations are considered for the blood perfusion

Fabrication and optimisation of a fused filament 3D-printed microfluidic platform

A 3D-printed microfluidic device was designed and manufactured using a low cost ($2000) consumer grade fusion deposition modelling (FDM) 3D printer. FDM printers are not typically used, or are capable, of producing the fine detailed structures required for microfluidic fabrication. However, in this work, the optical transparency of the device was improved through manufacture optimisation to such a point that optical colorimetric assays can be performed in a 50 µl device. A colorimetric enzymatic cascade assay was optimised using glucose oxidase and horseradish peroxidase for the oxidative coupling of aminoantipyrine and chromotropic acid to produce a blue quinoneimine dye with a broad absorbance peaking at 590 nm for the quantification of glucose in solution. For comparison the assay was run in standard 96 well plates with a commercial plate reader. The results show the accurate and reproducible quantification of 0–10 mM glucose solution using a 3D-printed microfluidic optical device with performance comparable to that of a plate reader assay

A solution to the slow stabilisation of surface pressure sensors based on the Wilhelmy method

Dynamic measurement of surface pressure is of particular interest in the field of Langmuir monolayers, where the change in surface pressure throughout an experiment can provide information on the properties of the monolayer forming material, or on the reaction kinetics of the monolayer’s interaction with other materials. One of the most common methods for the measurement of dynamic surface pressure is the Wilhelmy plate method. This method measures changes in the forces acting upon a thin plate of material at the air-water interface; this measurement is then converted to surface pressure. One version of this method, which uses filter paper plates at the air-water interface, is particularly popular due to their relatively low cost. However, it has been seen that the use of filter paper plates attached to a Wilhelmy balance requires an initial stabilisation period lasting several hours, during which the readings drift from the original baseline. Here the cause of this drift is explored, considering how changes in the weight of the plate over time influence the assumptions on which the surface pressure is derived from the measurements made by the Wilhelmy balance. A simple method for preventing this drift through pre-soaking of the filter paper plates is presented

Modifying monolayer behaviour by incorporating subphase additives and improving Langmuir–Blodgett thin film deposition on optical fibres

Experiments showing the possibility of modifying the behaviour of calix[4]resorcinarene monolayers at the air–water interface and optimising the deposition of multilayer coatings onto optical fibres are presented. The nature of the subphase is fundamental to the behaviour of monolayers and their utility in coating and sensing applications. Here we show initial studies exploring the modification of the calix[4]resorcinarene monolayer–water interaction through the introduction of dipole altering alcohol additives to the aqueous subphase. We explored the effect of this modification for three small alcohols. The resulting isotherms of the materials showed a reduction in the surface pressure and area per molecule required in order for the monolayer to reach its point of collapse. Incorporation of alcohols shifted the point of collapse, leading to the application of ethanol being successful in improving the transfer of material via Langmuir–Blodgett coating onto optical fibres at lower pressures. This method may prove useful in allowing greater control over future sensor surface coatings

The 2S(+) - 2P separation in KO

The 2S(+) - 2P separation in KO is investigated using large basis sets and high levels of correlation treatment. Relativistic effects are included at the Dirac-Fock level and reduce the separation only slightly. The basis set superposition error is considered in detail. On the basis of these calculations, our best estimate places the 2p sub 3/2 state about 200 cm(exp -1) above the ground 2 sigma(+) state in agreement with our previous estimate