Decay of fidelity in terms of correlation functions

We consider, within the algebraic formalism, the time dependence of fidelity for qubits encoded into an open physical system. We relate the decay of fidelity to the evolution of correlation functions and, in the particular case of a Markovian dynamics, to the spectral gap of the generator of the semigroup. The results are applicable to the analysis of models of quantum memories.Comment: 9 pages, no figure

PLASIM: A computer code for simulating charge exchange plasma propagation

The propagation of the charge exchange plasma for an electrostatic ion thruster is crucial in determining the interaction of that plasma with the associated spacecraft. A model that describes this plasma and its propagation is described, together with a computer code based on this model. The structure and calling sequence of the code, named PLASIM, is described. An explanation of the program's input and output is included, together with samples of both. The code is written in ANSI Standard FORTRAN

Matrix Metalloproteinases and Glaucoma Treatment.

Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that degrade extracellular matrix (ECM) components such as collagen and have important roles in multiple biological processes, including development and tissue remodeling, both in health and disease. The activity of MMPs is influenced by the expression of MMPs and tissue inhibitors of metalloproteinase (TIMPs). In the eye, MMP-mediated ECM turnover in the juxtacanalicular region of the trabecular meshwork (TM) reduces outflow resistance in the conventional outflow pathway and helps maintain intraocular pressure (IOP) homeostasis. An imbalance in the MMP/TIMP ratio may be involved in the elevated IOP often associated with glaucoma. The prostaglandin analog/prostamide (PGA) class of topical ocular hypotensive medications used in glaucoma treatment reduces IOP by increasing outflow through both conventional and unconventional (uveoscleral) outflow pathways. Evidence from in vivo and in vitro studies using animal models and anterior segment explant and cell cultures indicates that the mechanism of IOP lowering by PGAs involves increased MMP expression in the TM and ciliary body, leading to tissue remodeling that enhances conventional and unconventional outflow. PGA effects on MMP expression are dependent on the identity and concentration of the PGA. An intracameral sustained-release PGA implant (Bimatoprost SR) in development for glaucoma treatment can reduce IOP for many months after expected intraocular drug bioavailability. We hypothesize that the higher concentrations of bimatoprost achieved in ocular outflow tissues with the implant produce greater MMP upregulation and more extensive, sustained MMP-mediated target tissue remodeling, providing an extended duration of effect

Closing the design loop on HiMAT (highly maneuverable aircraft technology)

The design methodology used in the HiMAT program and the wind tunnel development activities are discussed. Selected results from the flight test program are presented and the strengths and weaknesses of testing advanced technology vehicles using the RPV concept is examined. The role of simulation on the development of digital flight control systems and in RPV's in particular is emphasized

Vitrification and determination of the crystallization time scales of the bulk-metallic-glass-forming liquid Zr58.5Nb2.8Cu15.6Ni12.8Al10.3

The crystallization kinetics of Zr58.5Nb2.8Cu15.6Ni12.8Al10.3 were studied in an electrostatic levitation (ESL) apparatus. The measured critical cooling rate is 1.75 K/s. Zr58.5Nb2.8Cu15.6Ni12.8Al10.3 is the first bulk-metallic-glass-forming liquid that does not contain beryllium to be vitrified by purely radiative cooling in the ESL. Furthermore, the sluggish crystallization kinetics enable the determination of the time-temperature-transformation (TTT) diagram between the liquidus and the glass transition temperatures. The shortest time to reach crystallization in an isothermal experiment; i.e., the nose of the TTT diagram is 32 s. The nose of the TTT diagram is at 900 K and positioned about 200 K below the liquidus temperature

A 128K-bit CCD buffer memory system

A prototype system was implemented to demonstrate that CCD's can be applied advantageously to the problem of low power digital storage and particularly to the problem of interfacing widely varying data rates. 8K-bit CCD shift register memories were used to construct a feasibility model 128K-bit buffer memory system. Peak power dissipation during a data transfer is less than 7 W., while idle power is approximately 5.4 W. The system features automatic data input synchronization with the recirculating CCD memory block start address. Descriptions are provided of both the buffer memory system and a custom tester that was used to exercise the memory. The testing procedures and testing results are discussed. Suggestions are provided for further development with regards to the utilization of advanced versions of CCD memory devices to both simplified and expanded memory system applications

Tracking TCRß sequence clonotype expansions during antiviral therapy using high-throughput sequencing of the hypervariable region

To maintain a persistent infection viruses such as hepatitis C virus (HCV) employ a range of mechanisms that subvert protective T cell responses. The suppression of antigen-specific T cell responses by HCV hinders efforts to profile T cell responses during chronic infection and antiviral therapy. Conventional methods of detecting antigen-specific T cells utilize either antigen stimulation (e.g., ELISpot, proliferation assays, cytokine production) or antigen-loaded tetramer staining. This limits the ability to profile T cell responses during chronic infection due to suppressed effector function and the requirement for prior knowledge of antigenic viral peptide sequences. Recently, high-throughput sequencing (HTS) technologies have been developed for the analysis of T cell repertoires. In the present study, we have assessed the feasibility of HTS of the TCRβ complementarity determining region (CDR)3 to track T cell expansions in an antigen-independent manner. Using sequential blood samples from HCV-infected individuals undergoing antiviral therapy, we were able to measure the population frequencies of >35,000 TCRβ sequence clonotypes in each individual over the course of 12 weeks. TRBV/TRBJ gene segment usage varied markedly between individuals but remained relatively constant within individuals across the course of therapy. Despite this stable TRBV/TRBJ gene segment usage, a number of TCRβ sequence clonotypes showed dramatic changes in read frequency. These changes could not be linked to therapy outcomes in the present study; however, the TCRβ CDR3 sequences with the largest fold changes did include sequences with identical TRBV/TRBJ gene segment usage and high junction region homology to previously published CDR3 sequences from HCV-specific T cells targeting the HLA-B*0801-restricted 1395HSKKKCDEL1403 and HLA-A*0101-restricted 1435ATDALMTGY1443 epitopes. The pipeline developed in this proof of concept study provides a platform for the design of future experiments to accurately address the question of whether T cell responses contribute to SVR upon antiviral therapy. This pipeline represents a novel technique to analyze T cell dynamics in situations where conventional antigen-dependent methods are limited due to suppression of T cell functions and highly diverse antigenic sequences

The star-formation history of the universe - an infrared perspective

A simple and versatile parameterized approach to the star formation history allows a quantitative investigation of the constraints from far infrared and submillimetre counts and background intensity measurements. The models include four spectral components: infrared cirrus (emission from interstellar dust), an M82-like starburst, an Arp220-like starburst and an AGN dust torus. The 60 $\mu$m luminosity function is determined for each chosen rate of evolution using the PSCz redshift data for 15000 galaxies. The proportions of each spectral type as a function of 60 $\mu$m luminosity are chosen for consistency with IRAS and SCUBA colour-luminosity relations, and with the fraction of AGN as a function of luminosity found in 12 $\mu$m samples. The luminosity function for each component at any wavelength can then be calculated from the assumed spectral energy distributions. With assumptions about the optical seds corresponding to each component and, for the AGN component, the optical and near infrared counts can be accurately modelled. A good fit to the observed counts at 0.44, 2.2, 15, 60, 90, 175 and 850 $\mu$m can be found with pure luminosity evolution in all 3 cosmological models investigated: $\Omega_o$ = 1, $\Omega_o$ = 0.3 ($\Lambda$ = 0), and $\Omega_o$ = 0.3, $\Lambda$ = 0.7. All 3 models also give an acceptable fit to the integrated background spectrum. Selected predictions of the models, for example redshift distributions for each component at selected wavelengths and fluxes, are shown. The total mass-density of stars generated is consistent with that observed, in all 3 cosmological models.Comment: 20 pages, 25 figures. Accepted for publication in ApJ. Full details of models can be found at http://astro.ic.ac.uk/~mrr/countmodel