Boost Camp’, a universal school-based transdiagnostic prevention program targeting adolescent emotion regulation; evaluating the effectiveness by a clustered RCT : a protocol paper

Abstract Background The transition from childhood into adolescence can be considered as a critical developmental period. Moreover, adolescence is associated with a decreased use of adaptive emotion regulation strategies and an increased use of maladaptive emotion regulation strategies increasing the risk of emotional problems. Targeting emotion regulation is therefore seen as an innovative prevention approach. The present study aims to evaluate the effectiveness of Boost camp, an innovative school-based prevention program targeting ER, on adolescents’ emotion regulation skills and emotional wellbeing. Also secondary outcomes and possible moderators will be included. Methods The aim is to reach 300 adolescents (16 class groups, 6 schools) in their first year of high school. A clustered Randomized Controlled Trial (RCT) with two conditions, intervention (n = 150) and control (n = 150), will be set up. Adolescents in the intervention condition will receive 14 lessons over the course of 2 days, followed by Booster sessions, and will be compared with adolescents in a non-intervention control group. The outcomes will be measured by self-report questionnaires at baseline, immediately after Boost camp, and at three and 6 months follow-up. Discussion Data-collection is planned to be completed in May 2018. Data-analyses will be finished the end of 2018. The presented paper describes the Boost camp program and the clustered RCT design to evaluate its effectiveness. It is expected that Boost camp will have beneficial effects. If found effective, Boost camp will have the potential to increase adolescent’s ER and well-being, and reduce the risk to become adults in need. The trials is registered on the 13th of June 2017 in ISRCTN registry [ISRCTN68235634]

Genome-Wide Association Study of Plasma Polyunsaturated Fatty Acids in the InCHIANTI Study

Polyunsaturated fatty acids (PUFA) have a role in many physiological processes, including energy production, modulation of inflammation, and maintenance of cell membrane integrity. High plasma PUFA concentrations have been shown to have beneficial effects on cardiovascular disease and mortality. To identify genetic contributors of plasma PUFA concentrations, we conducted a genome-wide association study of plasma levels of six omega-3 and omega-6 fatty acids in 1,075 participants in the InCHIANTI study on aging. The strongest evidence for association was observed in a region of chromosome 11 that encodes three fatty acid desaturases (FADS1, FADS2, FADS3). The SNP with the most significant association was rs174537 near FADS1 in the analysis of arachidonic acid (AA; p = 5.95×10−46). Minor allele homozygotes had lower AA compared to the major allele homozygotes and rs174537 accounted for 18.6% of the additive variance in AA concentrations. This SNP was also associated with levels of eicosadienoic acid (EDA; p = 6.78×10−9) and eicosapentanoic acid (EPA; p = 1.07×10−14). Participants carrying the allele associated with higher AA, EDA, and EPA also had higher low-density lipoprotein (LDL-C) and total cholesterol levels. Outside the FADS gene cluster, the strongest region of association mapped to chromosome 6 in the region encoding an elongase of very long fatty acids 2 (ELOVL2). In this region, association was observed with EPA (rs953413; p = 1.1×10−6). The effects of rs174537 were confirmed in an independent sample of 1,076 subjects participating in the GOLDN study. The ELOVL2 SNP was associated with docosapentanoic and DHA but not with EPA in GOLDN. These findings show that polymorphisms of genes encoding enzymes in the metabolism of PUFA contribute to plasma concentrations of fatty acids

Measurement of the forward-backward asymmetry in the B→K(*) μ\u3csup\u3e+\u3c/sup\u3eμ\u3csup\u3e-\u3c/sup\u3e decay and first observation of the Bs0→μ\u3csup\u3e+\u3c/sup\u3eμ\u3csup\u3e-\u3c/sup\u3e decay

We reconstruct the rare decays B+→K+μ +μ-, B0→K*(892)0μ +μ-, and Bs0→(1020)μ+μ - in a data sample corresponding to 4.4fb-1 collected in pp̄ collisions at √s=1.96TeV by the CDF II detector at the Tevatron Collider. Using 121±16 B+→K+μ +μ- and 101±12 B0→K*0μ +μ- decays we report the branching ratios. In addition, we report the differential branching ratio and the muon forward-backward asymmetry in the B+ and B0 decay modes, and the K*0 longitudinal polarization fraction in the B0 decay mode with respect to the squared dimuon mass. These are consistent with the predictions, and most recent determinations from other experiments and of comparable accuracy. We also report the first observation of the Bs0→μ+μ- decay and measure its branching ratio BR(Bs0→μ+μ-)= [1.44±0.33±0.46]×10-6 using 27±6 signal events. This is currently the most rare Bs0 decay observed. © 2011 American Physical Society

Search for a new heavy gauge boson W′ with event signature electron+missing transverse energy in pp̅ collisions at √s=1.96 TeV

We present a search for a new heavy charged vector boson W′ decaying to an electron-neutrino pair in pp̅ collisions at a center-of-mass energy of 1.96 TeV. The data were collected with the CDF II detector and correspond to an integrated luminosity of 5.3  fb-1. No significant excess above the standard model expectation is observed and we set upper limits on σ·B(W′→eν). Assuming standard model couplings to fermions and the neutrino from the W′ boson decay to be light, we exclude a W′ boson with mass less than 1.12  TeV/c2 at the 95% confidence level.We thank the Fermilab staff and the technical staffs of the participating institutions for their vital contributions. This work was supported by the U.S. Department of Energy and National Science Foundation; the Italian Istituto Nazionale di Fisica Nucleare; the Ministry of Education, Culture, Sports, Science and Technology of Japan; the Natural Sciences and Engineering Research Council of Canada; the National Science Council of the Republic of China; the Swiss National Science Foundation; the A. P. Sloan Foundation; the Bundesministerium für Balduin Una Forschung, Germany; the World Class University Program, the National Research Foundation of Korea; the Science and Technology Facilities Council and the Royal Society, United Kingdom; the Institut National de Physique Nucleaire et Physique des Particules/CNRS and Universite Pierre et Marie Curie; the Russian Foundation for Basic Research; the Ministerio de Ciencia e Innovación, and Programa Consolider-Ingenio 2010, Spain; the Slovak R&D Agency; and the Academy of Finland

Search for New Dielectron Resonances and Randall-Sundrum Gravitons at the Collider Detector at Fermilab

A search for new dielectron-mass resonances using data recorded by the CDF II detector and corresponding to an integrated luminosity of 5.7fb-1 is presented. No significant excess over the expected standard model prediction is observed. In this data set, an event with the highest dielectron mass ever observed (960GeV/c2) was recorded. The results are interpreted in the Randall-Sundrum (RS) model. Combined with the 5.4fb-1 diphoton analysis, the RS-graviton lower-mass limit for the coupling k/M ̄Pl=0.1 is 1058GeV/c2, making it the strongest limit to date. © 2011 American Physical Society

ENERGY EXPENDITURE AND CARDIORESPIRATORY RESPONSES FOR THREE QUADRUPEDAL RESISTANCE RAIL MOVEMENTS

W. M. Silvers Whitworth University, Spokane, WA While many benefits have been ascribed to high-intensity exercise (HIE), some modes such as sprint running and burpees involve large ground reaction forces, which may increase injury risk or joint pain. A new mode of exercise that involves quadrupedal movements performed on a set of resistance rails introduces a novel opportunity to perform HIE with reduced GRFs. PURPOSE: The aim of this study was to compare cardiorespiratory and metabolic responses for three quadrupedal resistance rail exercises. METHODS: Fifteen healthy, moderately active participants (nmale = 9, nfemale = 6; 21.5 ± 1.7 y, 171.7 ± ± 5.31 cm, 69.8 ± 12.7 kg) volunteered for participation. A familiarization session was used to instruct participants how to perform three quadrupedal movements on the resistance rails: mountain climbers (MC), spidermans (SP), and beast mode (BM). In a separate testing session, participants performed continuous 5 min bouts of exercise for each of the three movements at self-selected intensities, separated by 10 min of active recovery. During each bout, metabolic and cardiorespiratory data were recorded with a chest strap heart rate monitor, metabolic cart, and blood lactate analyzer. A repeated measures ANOVA was used to compare mean data for each dependent variable between movements. RESULTS: Oxygen consumption (MC: 24.76 ± 6.02 ml/kg/min, SP: 24.94 ± 5.11 ml/kg/min, BM: 24.70 ± 4.99 ml/kg/min, p = 0.99) and heart rate (MC: 154.7 ± 18.2 bpm, SP: 166.1 ± 12.8 bpm, BM: 166.8 ± 10.8 bpm, p = 0.232) were not different between movements. Conversely, delta lactate, calculated as the difference between resting and post-bout levels (MC: 7.0 ± 0.6 mmol/L, SP: 7.9 ± 0.7 mmol/L, BM: 8.9 ± 1.1 mmol/L, p = 0.002), and total energy expenditure (TEE), estimated as the sum of aerobic and anaerobic expenditure (MC: 18.5 ± 2.6 kcal/min, SP: 22.1 ± 3.6 kcal/min, BM: 24.4 ± 3.0 kcal/min, p = 0.008), were significantly different between movements. CONCLUSION: All quadrupedal movements performed on the resistance rails elicited heart rates at least 78% of age-predicted maximum, which demonstrates feasibility of this mode as a HIE option. In addition, the anaerobic contribution of energy expenditure disproportionately increased from MC to SP to BM, which may explain why VO2 measurements were similar across movements, yet TEE was different

A DESCRIPTIVE ASSESSMENT OF DAYTIME SLEEPINESS IN WILDLAND FIREFIGHTERS

M. Thomas, W. M. Silvers Whitworth University, Spokane, WA Wildland firefighters are often subject to long shift durations with limited recovery and sleep. Within this group, there are different job classifications whose recovery and sleep may be affected variably. PURPOSE: The purpose of this study was to describe daytime sleepiness (DS) among different classifications of wildland firefighters. METHODS: 18 full-time and temporary wildland firefighters volunteered to complete the Epworth Sleepiness Scale (ESS), which is a self-reported survey designed to assess DS. The questions address a variety of daily activities that could induce a wide range of sleepiness trends. Within the sample population, there were three job classifications represented: crew member, engine member, and supervisor. Descriptive statistics were utilized to summarize trends from the survey results. RESULTS: An ESS score above 10 represents abnormal DS, a score of 11-14 represents mild DS, a score of 15-18 equates to moderate DS, and any score above 18 constitutes severe DS. The median ESS score for the entire sample population was 7. Crew and engine members, each had median ESS scores of 8. Supervisors had a median ESS score of 6. CONCLUSION: It was expected that the sample population, or at least engine and crew members, would have ESS scores greater than 10. In the present descriptive study, this was not the case. Typically, August is the most demanding time period of the fire season, so the survey planned for administration at that time. However, for this sample population, the most demanding period of the 2021 fire season occurred earlier than normal (June and July), which allowed the fire personnel to be more rested during the assessment time in August. Future researchers should consider administering the ESS immediately upon checkout of 14-21 day fire assignments. Use of this timeline may improve the representativeness of ESS scores for the work conditions of interest. In addition, immediate assessment of ESS post-assignment may increase the size and diversity of the sample