EM BUSCA DAS ORIGENS: PENSANDO O PAPEL DA UNIVERSIDADE E SEUS COMPROMISSOS COM O DESENVOLVIMENTO LOCAL E DO PAÍS

Será a questão da gestão universitária o elemento mais importante a ser pensado quando discutimos o atual papel da universidade? Acreditamos que não, na medida em que uma universidade pode ter o melhor gestor que lhe é possível dispor, contudo, de nada adianta uma boa gestão se, esta, não estiver pautada em um projeto de universidade que vise a construção de conhecimentos socialmente referendados e válidos. Sobretudo, esse texto, trata-se de um artigo teórico-ensaístico que têm seu argumento principal baseado no suposto de que o conhecimento produzido no interior da universidade sempre esteve alicerçado num projeto de país. Nesse sentido, resulta de nossa análise como principal evidência a considerar, o fato de que, atualmente, em função de uma busca por maior inserção internacional e com vistas a se cumprir certos parâmetros de produtividade exigidos pela maioria das agências de fomento, esta, têm deixado de lado o seu referente social que é o território no qual está se insere e as demandas a este correlatas. Algo que, volta a agenda política a partir da criação de novas universidades federais que, instam as antigas, a retomar a sua natureza de outrora

Subjektkonstitutionen, Machtverhältnisse, Ästhetiken : Eine Analyse antiker Diskurse im Anschluss an den Strukturalismus Georges Dumézils

Eine Frühgeschichte der Subjektivität wie sie Michel Foucault vorgeschlagen hat, lässt sich um einige Aspekte erweitern, wenn man an die strukturalen Analysen indoeuropäischer Mythologien von Georges Dumézil anschliesst. In der folgenden Untersuchung wird das indoeuropäische Denken in der Rekonstruktion Dumézils mit einem einzelnen Text - Platons \u27Politeia\u27 - verglichen. In der Politeia wird eine bestimmte Denkfigur wieder aufgegriffen, die Dumézil als eine der Grundstrukturen indoeuropäischen mythologischen Denkens nachgewiesen hat: die \u27Ideologie der drei Funktionen\u27. Diese kann als differenzielles Schema verstanden werden, das von den Sprechenden angewendet wird, um die Welt zu ordnen und das differenzierte Inhaltsfelder produziert. So werden verschiedene Modelle von Subjektivierung, verschiedene Ãsthetiken, spezifische Machtkonstellationen hervorgebracht und nach derselben Struktur geordnet. Die differenzielle Struktur ist Teil der diskursiven Praxis, sie ist im Diskurs mit einer Reihe weiterer Elemente (Argumentationsstrukturen, narrativen Strukturen, Metaphern etc.) konstelliert. Die Analysen wurden auf dem Kongress \u27Postmoderne Perspektiven POMO 2000\u27 an der Universität Erlangen-Nürnberg vorgetragen. Eine stark gekürzte Fassung dieses Textes ist im Tagungsband erschienen: Angermüller, Johannes; Bunzmann, Katharina; Nonhoff, Martin (Hg.): Diskursanalyse. Hamburg: Argument 200

Eurozone sovereign bonds and rating assessments: impact on volatility

Rating agencies have been very active during the economic crisis and have been blamed for damaging the refinancing possibilities of the eurozone countries. Their decisions concerning sovereign bonds have been widely pointed out as one of the reasons why spreads rose dramatically between 2009 and 2012. Nonetheless, last evolutions of the sovereign spreads in countries such as Spain, Ireland or France show that sovereigns do not respond to rating assessments as extremely as they did before. Therefore, economic actors may wonder whether there has been a recent change in the trend or by contrast those assessments did not influence the volatility of the spreads, which may have been motivated by other variables. In this paper we will intend to determine to what extent S&P announcements were drivers of higher volatility of sovereign bonds’ spreads and how these effects (if any) have evolved over the economic crisis

Return to a coherent city: on the example of Lublin

This article discusses a very important and current problem of the loss of integrity in Lublin. It also contains suggestions for the improvement of present situation and preventing the problem in the future. The paper is a continuation of research conducted by J. Wrana as part of habilitation thesis entitled “The role and importance of architecture in the process of integrating the spatial structure of the city – on the example of Lublin”. One of the methods of integrating urban spatial structure is conscious creation of architectural forms, and their increasing significance in the formation of “synergy” relations. The binder of “re-integration” city could be the “integration architecture” - buildings of high quality, socially attractive features, located in the important nodal points, which improve the consistency of the environment. Supplementing the city with such facilities greatly increases its aesthetics, also associated with consistency. Their functions are not only the classic ones (services, education, etc.) as in various ways, they also influence city landscapes. They complete street frontages, integrate campuses and housing estates, create composition axes, integrate surroundings, and enrich the services. The authors focus on the example of Lublin – a centuries-old city with rich and fascinating history, nowadays dealing with its post-industrial heritage and facing spatial problems. The city is regaining its lost integrity through architecture: it has become a place where a number of noteworthy integrating projects have been realised. The examples of integration architecture in Lublin are, among others: Centre for the Meeting of Cultures “Theatre in Construction” and Eastern Innovation Centre of Architecture (Lublin University of Technology)

Merkel cell polyomavirus large T antigen disrupts lysosome clustering by translocating human Vam6p from the cytoplasm to the nucleus

Merkel cell polyomavirus (MCV) has been recently described as the cause for most human Merkel cell carcinomas. MCV is similar to simian virus 40 (SV40) and encodes a nuclear large T (LT) oncoprotein that is usually mutated to eliminate viral replication among tumor-derived MCV. We identified the hVam6p cytoplasmic protein involved in lysosomal processing as a novel interactor with MCV LT but not SV40 LT. hVam6p binds through its clathrin heavy chain homology domain to a unique region of MCV LT adjacent to the retinoblastoma binding site. MCV LT translocates hVam6p to the nucleus, sequestering it from involvement in lysosomal trafficking. A naturally occurring, tumor-derived mutant LT (MCV350) lacking a nuclear localization signal binds hVam6p but fails to inhibit hVam6p-induced lysosomal clustering. MCV has evolved a novel mechanism to target hVam6p that may contribute to viral uncoating or egress through lysosomal processing during virus replication

Biological activity differences between TGF-β1 and TGF-β3 correlate with differences in the rigidity and arrangement of their component monomers

[Image: see text] TGF-β1, -β2, and -β3 are small, secreted signaling proteins. They share 71–80% sequence identity and signal through the same receptors, yet the isoform-specific null mice have distinctive phenotypes and are inviable. The replacement of the coding sequence of TGF-β1 with TGF-β3 and TGF-β3 with TGF-β1 led to only partial rescue of the mutant phenotypes, suggesting that intrinsic differences between them contribute to the requirement of each in vivo. Here, we investigated whether the previously reported differences in the flexibility of the interfacial helix and arrangement of monomers was responsible for the differences in activity by generating two chimeric proteins in which residues 54–75 in the homodimer interface were swapped. Structural analysis of these using NMR and functional analysis using a dermal fibroblast migration assay showed that swapping the interfacial region swapped both the conformational preferences and activity. Conformational and activity differences were also observed between TGF-β3 and a variant with four helix-stabilizing residues from TGF-β1, suggesting that the observed changes were due to increased helical stability and the altered conformation, as proposed. Surface plasmon resonance analysis showed that TGF-β1, TGF-β3, and variants bound the type II signaling receptor, TβRII, nearly identically, but had small differences in the dissociation rate constant for recruitment of the type I signaling receptor, TβRI. However, the latter did not correlate with conformational preference or activity. Hence, the difference in activity arises from differences in their conformations, not their manner of receptor binding, suggesting that a matrix protein that differentially binds them might determine their distinct activities