Evaluation and treatment decision of pancreatic tumors by use of MRI with MRCP imaging

Background: Pancreatic cancer is one of the most malignant tumors. Symptoms are usually nonspecific and insidious such that the cancer is advanced by the time of diagnosis. The aim of our work was to investigate the use of MRI and MRCP in diagnosis of the patients suspected of pancreatic carcinoma and to determine the role of these methods in the evaluation of resectability of pancreatic cancer in comparison to surgical findings. Material/Methods: Forty-nine patients (33 men and 16 women) aged 44-82 had undergone to MRI and MRCP imagination of the upper abdomen on 1.5 T system with use of a standard flexible surface coil. The results of those radiological diagnostic tests were compare to the surgical findings and histopathological examination. The capacity of MR and MRCP to detect pathological mass, assess disease process nature and accuracy of assessment of the resectability of the malignant lesion were evaluated. In the statistical analysis test X2 and Fisher's precise test were performed. Results: A statistical analysis determined 88% sensitivity, 95% specifity and 94% exactness of MRI and MRCP in the evaluation of nature of tumors within the pancreas and 100% sensitivity, 91% specificity and 95% accuracy in determining the resectability of the lesion. The positive predictive value came to 83%, while the negative predictive value to 100%. The Kappa compatibility index in comparison with a surgical findings came to 0.85714. Conclusions: MR and MRCP appears an important stage in diagnosis and in assessment of pancreatic tumors. By the estimation of tumor respectability it aids clinical management

The "Brest Bible" ["Biblia brzeska"] and Europe after 450 years : perspectives for new research and promotional activity of Mikołaj "the Black" Radziwiłł

The article presents the current state of research and outlines plans for further studies on one of the most important translations of the Holy Scriptures into Polish, the so-called Brest Bible, or the Radziwiłł Bible (1563). In the second part, on the basis of Latin sources, the paper analyses the promotion of this edition conducted in Europe by Mikołaj "the Black" Radziwiłł, the initiator of the publication

On the "Brest Bible" : the anniversary notebook No. 2

The introduction presents the next stage in the research on the Brest Bible. It is the result of the conference organized in Brest in 2015, which was a continuation of a symposium that was also held in Brest to commemorate the 450th anniversary of the Radziwiłł Bible. The author presented main avenues of research on the Brest treasure and surveyed the themes of papers delivered by the participants. Their articles are included in the present volume of "Tematy i Konteksty"

CT diagnosis of early stroke : the initial approach to the new CAD tool based on multiscale estimation of ischemia

Background: Computer aided diagnosis (CAD) becomes one of the most important diagnostic tools for urgent states in cerebral stroke and other life-threatening conditions where time plays a crucial role. Routine CT is still diagnostically insufficient in hyperacute stage of stroke that is in the therapeutic window for thrombolytic therapy. Authors present computer assistant of early ischemic stroke diagnosis that supports the radiologic interpretations. A new semantic-visualization system of ischemic symptoms applied to noncontrast, routine CT examination was based on multiscale image processing and diagnostic content estimation. Material/Methods: Evaluation of 95 sets of examinations in patients admitted to a hospital with symptoms suggesting stroke was undertaken by four radiologists from two medical centers unaware of the final clinical findings. All of the consecutive cases were considered as having no CT direct signs of hyperacute ischemia. At the first test stage only the CTs performed at the admission were evaluated independently by radiologists. Next, the same early scans were evaluated again with additional use of multiscale computer-assistant of stroke (MulCAS). Computerized suggestion with increased sensitivity to the subtle image manifestations of cerebral ischemia was constructed as additional view representing estimated diagnostic content with enhanced stroke symptoms synchronized to routine CT data preview. Follow-up CT examinations and clinical features confirmed or excluded the diagnosis of stroke constituting 'gold standard' to verify stroke detection performance. Results: Higher AUC (area under curve) values were found for MulCAS -aided radiological diagnosis for all readers and the differences were statistically significant for random readers-random cases parametric and non-parametric DBM MRMC analysis. Sensitivity and specificity of acute stroke detection for the readers was increased by 30% and 4%, respectively. Conclusions: Routine CT completed with proposed method of computer assisted diagnosis provided noticeable better diagnosis efficiency of acute stroke according to the rates and opinions of all test readers. Further research includes fully automatic detection of hypodense regions to complete assisted indications and formulate the suggestions of stroke cases more objectively. Planned prospective studies will let evaluate more accurately the impact of this CAD tool on diagnosis and further treatment in patients suffered from stroke. It is necessary to determine whether this method is possible to be applied widely

DeepCoder: Semi-parametric Variational Autoencoders for Automatic Facial Action Coding

Human face exhibits an inherent hierarchy in its representations (i.e., holistic facial expressions can be encoded via a set of facial action units (AUs) and their intensity). Variational (deep) auto-encoders (VAE) have shown great results in unsupervised extraction of hierarchical latent representations from large amounts of image data, while being robust to noise and other undesired artifacts. Potentially, this makes VAEs a suitable approach for learning facial features for AU intensity estimation. Yet, most existing VAE-based methods apply classifiers learned separately from the encoded features. By contrast, the non-parametric (probabilistic) approaches, such as Gaussian Processes (GPs), typically outperform their parametric counterparts, but cannot deal easily with large amounts of data. To this end, we propose a novel VAE semi-parametric modeling framework, named DeepCoder, which combines the modeling power of parametric (convolutional) and nonparametric (ordinal GPs) VAEs, for joint learning of (1) latent representations at multiple levels in a task hierarchy1, and (2) classification of multiple ordinal outputs. We show on benchmark datasets for AU intensity estimation that the proposed DeepCoder outperforms the state-of-the-art approaches, and related VAEs and deep learning models.Comment: ICCV 2017 - accepte

Evaluation of radiological and clinical efficacy of ^{90}Y-DOTATATE} therapy in patients with progressive metastatic midgut neuroendocrine carcinomas

Background: To evaluate the radiological and clinical therapeutic effectiveness of ^{90}Y-octreotate [DOTATATE] inpatients with progressive somatostatin receptor-positive midgut neuroendocrine carcinomas (GEPNETs). Material/Methods: The study group: 34 patients, with histological proven extensive non-resectable and progressive midgut GEP-NETs. Radionuclide therapy (^{90}Y-DOTATATE) was given i.v. with a mean activity per administration 3,82 GBq. Initial clinical tumor responses were assessed 6-7 weeks after therapy completion and then once 3-monthly. The objective tumor response was classified according to the RECIST, initially between 4-6 months and then after each of the 6 months interval. Results: At 6 months after treatment completion, radiological tumor response was observed in 6 subjects with PR (19%), 25 presented SD (78%) and single had PD (3%). Overall clinical response to therapy at 6 months follow-up was observed in 23 patients (68%), SD in 5 patients (15%) and PD in 6 (18%). A year after therapy radiological tumour response was seen in 11 patients (44%), SD had 12 subjects (44%) and DP was noted in 2 patients. Two years after completed therapy PR was seen in 6 patients (33%), SD in additional 11 subjects (61%), single patient had PD. Clinical response to treatment in terms of PR and SD were noted in 22 patients (88%) after 1 year and in 14 patients (87%) after 2 years. Median PFS was 20 months, while the median OS was 23 months. In the 6 patients with clinical PD within initial 6 months the median PFS was 6 months and OS 11 months, while in those with SD or PR PFS was 22 months and OS 26 months (P<0.05). Conclusions: Therapy with ^{90}Y-DOTATATE} is effective in terms of clinical response, however the radiological response measured by the RECIST criteria underestimates benefits of this type of therapy in patients with progressive somatostatin receptor-positive midgut neuroendocrine carcinomas

Caveolin-3 differentially orchestrates cholinergic and serotonergic constriction of murine airways

The mechanisms of controlling airway smooth muscle (ASM) tone are of utmost clinical importance as inappropriate constriction is a hallmark in asthma and chronic obstructive pulmonary disease. Receptors for acetylcholine and serotonin, two relevant mediators in this context, appear to be incorporated in specialized, cholesterol-rich domains of the plasma membrane, termed caveolae due to their invaginated shape. The structural protein caveolin-1 partly accounts for anchoring of these receptors. We here determined the role of the other major caveolar protein, caveolin-3 (cav-3), in orchestrating cholinergic and serotonergic ASM responses, utilizing newly generated cav-3 deficient mice. Cav-3 deficiency fully abrogated serotonin-induced constriction of extrapulmonary airways in organ baths while leaving intrapulmonary airways unaffected, as assessed in precision cut lung slices. The selective expression of cav-3 in tracheal, but not intrapulmonary bronchial epithelial cells, revealed by immunohistochemistry, might explain the differential effects of cav-3 deficiency on serotonergic ASM constriction. The cholinergic response of extrapulmonary airways was not altered, whereas a considerable increase was observed in cav-3â -/- intrapulmonary bronchi. Thus, cav-3 differentially organizes serotonergic and cholinergic signaling in ASM through mechanisms that are specific for airways of certain caliber and anatomical position. This may allow for selective and site-specific intervention in hyperreactive states