Assisted assignment of automotive safety requirements

ISO 26262, a functional-safety standard, uses Automotive Safety Integrity Levels (ASILs) to assign safety requirements to automotive-system elements. System designers initially assign ASILs to system-level hazards and then allocate them to elements of the refined system architecture. Through ASIL decomposition, designers can divide a function & rsquo;s safety requirements among multiple components. However, in practice, manual ASIL decomposition is difficult and produces varying results. To overcome this problem, a new tool automates ASIL allocation and decomposition. It supports the system and software engineering life cycle by enabling users to efficiently allocate safety requirements regarding systematic failures in the design of critical embedded computer systems. The tool is applicable to industries with a similar concept of safety integrity levels. © 1984-2012 IEEE

Evaluation of the Coverage of 3 Antibiotic Regimens for Neonatal Sepsis in the Hospital Setting Across Asian Countries.

Importance: High levels of antimicrobial resistance in neonatal bloodstream isolates are being reported globally, including in Asia. Local hospital antibiogram data may include too few isolates to meaningfully examine the expected coverage of antibiotic regimens. Objective: To assess the coverage offered by 3 antibiotic regimens for empirical treatment of neonatal sepsis in Asian countries. Design, Setting, and Participants: A decision analytical model was used to estimate coverage of 3 prespecified antibiotic regimens according to a weighted-incidence syndromic combination antibiogram. Relevant data to parameterize the models were identified from a systematic search of Ovid MEDLINE and Embase. Data from Asian countries published from 2014 onward were of interest. Only data on blood culture isolates from neonates with sepsis, bloodstream infection, or bacteremia reported from the relevant setting were included. Data analysis was performed from April 2019 to July 2019. Exposures: The prespecified regimens of interest were aminopenicillin-gentamicin, third-generation cephalosporins (cefotaxime or ceftriaxone), and meropenem. The relative incidence of different bacteria and their antimicrobial susceptibility to antibiotics relevant for determining expected concordance with these regimens were extracted. Main Outcomes and Measures: Coverage was calculated on the basis of a decision-tree model incorporating relative bacterial incidence and antimicrobial susceptibility of relevant isolates. Data on 7 bacteria most commonly reported in the included studies were used for estimating coverage, which was reported at the country level. Results: Data from 48 studies reporting on 10 countries and 8376 isolates were used. Individual countries reported 51 (Vietnam) to 6284 (India) isolates. Coverage varied considerably between countries. Meropenem was generally estimated to provide the highest coverage, ranging from 64.0% (95% credible interval [CrI], 62.6%-65.4%) in India to 90.6% (95% CrI, 86.2%-94.4%) in Cambodia, followed by aminopenicillin-gentamicin (from 35.9% [95% CrI, 27.7%-44.0%] in Indonesia to 81.0% [95% CrI, 71.1%-89.7%] in Laos) and cefotaxime or ceftriaxone (from 17.9% [95% CrI, 11.7%-24.7%] in Indonesia to 75.0% [95% CrI, 64.8%-84.1%] in Laos). Aminopenicillin-gentamicin coverage was lower than that of meropenem in all countries except Laos (81.0%; 95% CrI, 71.1%-89.7%) and Nepal (74.3%; 95% CrI, 70.3%-78.2%), where 95% CrIs for aminopenicillin-gentamicin and meropenem were overlapping. Third-generation cephalosporin coverage was lowest of the 3 regimens in all countries. The coverage difference between aminopenicillin-gentamicin and meropenem for countries with nonoverlapping 95% CrIs ranged from -15.9% in China to -52.9% in Indonesia. Conclusions and Relevance: This study's findings suggest that noncarbapenem antibiotic regimens may provide limited coverage for empirical treatment of neonatal sepsis in many Asian countries. Alternative regimens must be studied to limit carbapenem consumption

Practice Makes Imperfect: Restorative Effects of Sleep on Motor Learning

Emerging evidence suggests that sleep plays a key role in procedural learning, particularly in the continued development of motor skill learning following initial acquisition. We argue that a detailed examination of the time course of performance across sleep on the finger-tapping task, established as the paradigm for studying the effect of sleep on motor learning, will help distinguish a restorative role of sleep in motor skill learning from a proactive one. Healthy subjects rehearsed for 12 trials and, following a night of sleep, were tested. Early training rapidly improved speed as well as accuracy on pre-sleep training. Additional rehearsal caused a marked slow-down in further improvement or partial reversal in performance to observed levels below theoretical upper limits derived on the basis of early pre-sleep rehearsal. This decrement in learning efficacy does not occur always, but if and only if it does, overnight sleep has an effect in fully or partly restoring the efficacy and actual performance to the optimal theoretically achieveable level. Our findings re-interpret the sleep-dependent memory enhancement in motor learning reported in the literature as a restoration of fatigued circuitry specialized for the skill. In providing restitution to the fatigued brain, sleep eliminates the rehearsal-induced synaptic fatigue of the circuitry specialized for the task and restores the benefit of early pre-sleep rehearsal. The present findings lend support to the notion that latent sleep-dependent enhancement of performance is a behavioral expression of the brain's restitution in sleep

Topological surface states above the Fermi energy in Hf2Te2P\textrm{Hf}_{2}\textrm{Te}_2\textrm{P}

We report a detailed experimental study of the band structure of the recently discovered topological material $\textrm{Hf}_{2}\textrm{Te}_2\textrm{P}$. Using the combination of scanning tunneling spectroscopy and angle-resolved photo-emission spectroscopy with surface K-doping, we probe the band structure of $\textrm{Hf}_{2}\textrm{Te}_2\textrm{P}$ with energy and momentum resolution above the Fermi level. Our experiments show the presence of multiple surface states with a linear Dirac-like dispersion, consistent with the predictions from previously reported band structure calculations. In particular, scanning tunneling spectroscopy measurements provide the first experimental evidence for the strong topological surface state predicted at 460 meV, which stems from the band inversion between Hf-d and Te-p orbitals. This band inversion comprised of more localized d-states could result in a better surface-to-bulk conductance ratio relative to more traditional topological insulators.Comment: Supplementary materials available upon reques

Quantitative Evidence for an Intrinsic Age Spread in the Orion Nebula Cluster

Aims. We present a study of the distribution of stellar ages in the Orion Nebula Cluster (ONC) based on accurate HST photometry taken from the HST Treasury Program observations of the ONC utilizing the most recent estimate of the cluster's distance (Menten et al. 2007). We investigate the presence of an intrinsic age spread in the region and a possible trend of age with the spatial distribution. Methods. We estimate the extinction and accretion luminosity towards each source by performing synthetic photometry on an empirical calibration of atmospheric models (Da Rio et al. 2010) using the package Chorizos (Maiz-Apellaniz 2004). The position of the sources in the HR-diagram is compared with different theoretical isochrones to estimate the mean cluster age and age dispersion. Through Monte Carlo simulations we quantify the amount of intrinsic age spread in the region, taking into account uncertainties on the distance, spectral type, extinction, unresolved binaries, accretion and photometric variability. Results. According to Siess et al. (2000) evolutionary models the mean age of the Cluster is 2.2 Myr with a scatter of few Myrs. With Monte Carlo simulations we find that the observed age spread is inconsistent with a coeval stellar population, but is in agreement with a star formation activity between 1.5 and 3.5 Myrs. We also observe light evidence for a trend of ages with spatial distribution.Comment: 12 pages, 12 figures, Accepted for publication in Astronomy and Astrophysic

The assessment of science: the relative merits of post- publication review, the impact factor, and the number of citations

The assessment of scientific publications is an integral part of the scientific process. Here we investigate three methods of assessing the merit of a scientific paper: subjective post-publication peer review, the number of citations gained by a paper, and the impact factor of the journal in which the article was published. We investigate these methods using two datasets in which subjective post-publication assessments of scientific publications have been made by experts. We find that there are moderate, but statistically significant, correlations between assessor scores, when two assessors have rated the same paper, and between assessor score and the number of citations a paper accrues. However, we show that assessor score depends strongly on the journal in which the paper is published, and that assessors tend to over-rate papers published in journals with high impact factors. If we control for this bias, we find that the correlation between assessor scores and between assessor score and the number of citations is weak, suggesting that scientists have little ability to judge either the intrinsic merit of a paper or its likely impact. We also show that the number of citations a paper receives is an extremely error-prone measure of scientific merit. Finally, we argue that the impact factor is likely to be a poor measure of merit, since it depends on subjective assessment. We conclude that the three measures of scientific merit considered here are poor; in particular subjective assessments are an error-prone, biased, and expensive method by which to assess merit. We argue that the impact factor may be the most satisfactory of the methods we have considered, since it is a form of pre-publication review. However, we emphasise that it is likely to be a very error-prone measure of merit that is qualitative, not quantitative

Diagnóstico de áreas degradadas ripárias no Rio São Francisco: criação e utilização de banco de dados relacional.

Para compor um programa de recuperação de ambientes ripários no Semiárido, diagnósticos foram realizados com a finalidade de embasar planos de manejo. Contudo, as variáveis utilizadas por cada área de estudo acumulavam-se em um grande número de dados e informações, tornando o diagnóstico de difícil entendimento, por dificuldades de se relacionarem todos os dados coletados. Assim, o objetivo deste trabalho foi criar um banco de dados relacional para a manipulação de todos os dados e informações referentes ao diagnóstico de áreas degradadas ciliares do Rio São Francisco na RIDE de Petrolina?Juazeiro. Para a construção do sistema de banco de dados relacional utilizou-se a ferramenta MySQL. Esse sistema possibilita ter vários usuários, com acesso de diferentes locais. As tabelas de dados foram trabalhadas nos editores de planilhas BrOffice Calc ou Excel. O software (interface) utilizado para dar acesso, exportação e importação dos dados foi o phpMyadmin. Após a criação e utilização do banco de dados, constatou-se que o banco de dados desenvolvido atende a necessidade de pesquisa relacional, uma vez que permite utilizar um número de identificação (ID), de fácil acesso e manipulação, gerado a partir do estabelecimento de relações entre as variáveis analisadas

Study of the Sextans dwarf spheroidal galaxy from the DART CaII triplet survey

We use VLT/FLAMES intermediate resolution (R~6500) spectra of individual red giant branch stars in the near-infrared CaII triplet (CaT) region to investigate the wide-area metallicity properties and internal kinematics of the Sextans dwarf spheroidal galaxy (dSph). Our final sample consists of 174 probable members of Sextans with accurate line-of-sight velocities (+- 2 km/s) and CaT [Fe/H] measurements (+- 0.2 dex). We use the MgI line at 8806.8 \AA\, as an empirical discriminator for distinguishing between probable members of the dSph (giant stars) and probable Galactic contaminants (dwarf stars). Sextans shows a similar chemo-dynamical behaviour to other Milky Way dSphs, with its central regions being more metal rich than the outer parts and with the more metal-rich stars displaying colder kinematics than the more metal-poor stars. Hints of a velocity gradient are found along the projected major axis and along an axis at P.A.=191 deg, however a larger and more spatially extended sample may be necessary to pin down the amplitude and direction of this gradient. We detect a cold kinematic substructure at the centre of Sextans, consistent with being the remnant of a disrupted very metal poor stellar cluster. We derive the most extended line-of-sight velocity dispersion profile for Sextans, out to a projected radius of 1.6 deg. From Jeans modelling of the observed line-of-sight velocity dispersion profile we find that this is consistent with both a cored dark matter halo with large core radius and cuspy halo with low concentration. The mass within the last measured point is in the range 2-4 x 10^8 M_sun, giving very large mass-to-light ratios, from 460 to 920 (M/L)_(V,sun).Comment: 30 pages, 17 figures; 4 tables. Accepted for publication in MNRAS. Table 4 will appear as online material in the published version of the manuscript. Typo correcte

The Carina Project. VIII. The {\alpha}-element abundances

We have performed a new abundance analysis of Carina Red Giant (RG) stars from spectroscopic data collected with UVES (high resolution) and FLAMES/GIRAFFE (high and medium resolution) at ESO/VLT. The former sample includes 44 RGs, while the latter consists of 65 (high) and ~800 (medium resolution) RGs, covering a significant fraction of the galaxy's RG branch (RGB), and red clump stars. To improve the abundance analysis at the faint magnitude limit, the FLAMES/GIRAFFE data were divided into ten surface gravity and effective temperature bins. The spectra of the stars belonging to the same gravity/temperature bin were stacked. This approach allowed us to increase by at least a factor of five the signal-to-noise ratio in the faint limit (V>20.5mag). We took advantage of the new photometry index cU,B,I introduced by Monelli et al. (2014), as an age and probably a metallicity indicator, to split stars along the RGB. These two stellar populations display distinct [Fe/H] and [Mg/H] distributions: their mean Fe abundances are -2.15$\pm$0.06dex (sig=0.28), and -1.75$\pm$0.03dex (sig=0.21), respectively. The two iron distributions differ at the 75% level. This supports preliminary results by Lemasle et al. (2012) and by Monelli et al. (2014). Moreover, we found that the old and intermediate-age stellar populations have mean [Mg/H] abundances of -1.91$\pm$0.05dex (sig=0.22) and -1.35$\pm$0.03dex (sig=0.22); these differ at the 83% level. Carina's {\alpha}-element abundances agree, within 1sigma, with similar abundances for field Halo stars and for cluster (Galactic, Magellanic) stars. The same outcome applies to nearby dwarf spheroidals and ultra-faint dwarf galaxies, in the iron range covered by Carina stars. Finally, we found evidence of a clear correlation between Na and O abundances, thus suggesting that Carina's chemical enrichment history is quite different than in the globular clusters.Comment: 21 pages, 19 figures, 11 tables, accepted for publication in A&

GPs’ strategies in exploring the preschool child’s wellbeing in the paediatric consultation

Background: Although General Practitioners (GPs) are uniquely placed to identify children with emotional, social, and behavioural problems, they succeed in identifying only a small number of them. The aim of this article is to explore the strategies, methods, and tools employed by GPs in the assessment of the preschool child’s emotional, mental, social, and behavioural health. We look at how GPs address parental care of the child in general and in situations where GPs have a particular awareness of the child. Method: Twenty-eight Danish GPs were purposively selected to take part in a qualitative study which combined focus-group discussions, observation of child consultations, and individual interviews with GPs. Results: Analysis of the data suggests that GPs have developed a set of methods, and strategies to assess the preschool child and parental care of the child. They look beyond paying narrow attention to the physical health of the child and they have expanded their practice to include the relations and interactions in the consultation room. The physical examination of the child continues to play a central role in doctor-child communication. Conclusion: The participating GPs’ strategies helped them to assess the wellbeing of the preschool child but they often find it difficult to share their impressions with parents