Plasma adrenomedullin level in patients with heart failure is related to systolic but not diastolic dysfunction

published_or_final_versio

Nitric oxide (NO) levels in exhaled air, sputum, serum, saliva, and urine of bronchiectasis subjects: a comparision study

Session - Respiratory & Critical Care Medicine: no. S-RC-1published_or_final_versio

Quantitative analysis of anti-hepatitis C virus anti body-secreting B cells in patients with chronic hepatitis C

Copyright © 2006 American Association for the Study of Liver DiseasesArticleHEPATOLOGY. 43(1): 91-99 (2006)journal articl

Pro-inflammatory role of gastro-oesophageal reflux (GOR) in steady state bronchiectasis

Session - Respiratory & Critical Care Medicine: no. G-RC-3published_or_final_versio

Towards reconciling structure and function in the nuclear pore complex

The spatial separation between the cytoplasm and the cell nucleus necessitates the continuous exchange of macromolecular cargo across the double-membraned nuclear envelope. Being the only passageway in and out of the nucleus, the nuclear pore complex (NPC) has the principal function of regulating the high throughput of nucleocytoplasmic transport in a highly selective manner so as to maintain cellular order and function. Here, we present a retrospective review of the evidence that has led to the current understanding of both NPC structure and function. Looking towards the future, we contemplate on how various outstanding effects and nanoscopic characteristics ought to be addressed, with the goal of reconciling structure and function into a single unified picture of the NPC

Experimental arthritis induced by a clinical Mycoplasma fermentans isolate

BACKGROUND: Mycoplasma fermentans has been associated with rheumatoid arthritis. Recently, it was detected in the joints and blood of patients with rheumatoid arthritis, but it is not clear yet how the bacteria enter the body and reach the joints. The purpose of this study was to determine the ability of M. fermentans to induce experimental arthritis in rabbits following inoculation of the bacteria in the trachea and knee joints. METHODS: P-140 and PG-18 strains were each injected in the knee joints of 14 rabbits in order to evaluate and compare their arthritogenicity. P-140 was also injected in the trachea of 14 rabbits in order to test the ability of the bacteria to reach the joints and induce arthritis. RESULTS: M. fermentans produced an acute arthritis in rabbits. Joint swelling appeared first in rabbits injected with P-140, which caused a more severe arthritis than PG-18. Both strains were able to migrate to the uninoculated knee joints and they were detected viable in the joints all along the duration of the experiment. Changes in the synovial tissue were more severe by the end of the experiment and characterized by the infiltration of neutrophils and substitution of adipose tissue by connective tissue. Rabbits intracheally injected with P-140 showed induced arthritis and the bacteria could be isolated from lungs, blood, heart, kidney, spleen, brain and joints. CONCLUSION: M. fermentans induced arthritis regardless of the inoculation route. These findings may help explain why mycoplasmas are commonly isolated from the joints of rheumatic patients

Ready for O4 II: GRANDMA Observations of Swift GRBs during eight-weeks of Spring 2022

We present a campaign designed to train the GRANDMA network and its infrastructure to follow up on transient alerts and detect their early afterglows. In preparation for O4 II campaign, we focused on GRB alerts as they are expected to be an electromagnetic counterpart of gravitational-wave events. Our goal was to improve our response to the alerts and start prompt observations as soon as possible to better prepare the GRANDMA network for the fourth observational run of LIGO-Virgo-Kagra (which started at the end of May 2023), and future missions such as SM. To receive, manage and send out observational plans to our partner telescopes we set up dedicated infrastructure and a rota of follow-up adcates were organized to guarantee round-the-clock assistance to our telescope teams. To ensure a great number of observations, we focused on Swift GRBs whose localization errors were generally smaller than the GRANDMA telescopes' field of view. This allowed us to bypass the transient identification process and focus on the reaction time and efficiency of the network. During 'Ready for O4 II', 11 Swift/INTEGRAL GRB triggers were selected, nine fields had been observed, and three afterglows were detected (GRB 220403B, GRB 220427A, GRB 220514A), with 17 GRANDMA telescopes and 17 amateur astronomers from the citizen science project Kilonova-Catcher. Here we highlight the GRB 220427A analysis where our long-term follow-up of the host galaxy allowed us to obtain a photometric redshift of $z=0.82\pm0.09$, its lightcurve elution, fit the decay slope of the afterglows, and study the properties of the host galaxy

Quantitative analysis of anti-hepatitis C virus anti body-secreting B cells in patients with chronic hepatitis C

Copyright © 2006 American Association for the Study of Liver DiseasesArticleapplication/pdfHEPATOLOGY. 43(1): 91-99 (2006)journal articl

Characteristic Analysis of Four Major Nighttime Fire Cases on Fire Safety of Long-Term Care Institutions Using Fire Protection Defense-In-Depth Strategy

Providing high-quality care services and fire safety for long-term care institutions is an important issue in Taiwan, which became an aging society in 2018. The fire incidents in Taiwan over the years show that nighttime fires in care institutions often cause serious casualties. It is necessary not only to understand the causes of serious nighttime fire incidents that have occurred but also to draw lessons from the fires that have been put out without causing injuries. In this study, the top two serious nighttime fire accidents in long-term care institutions in the past two decades in Taiwan were analyzed based on the publicly official and academic literature utilizing fire protection defense-in-depth strategies. For comparison, two other nighttime fire cases with similar scenarios but no casualties were also analyzed in depth about the cause of no casualties. The buildings of the four nighttime fires were equipped with fire protection equipment in their public areas. The theoretical basis of the research is the fire protection defense-in-depth strategy. In both categories of severe casualties and no severe casualties, one was caused by arson and the other one by an electrical fire, with the ignition point of a fire in the storeroom and the other in the ward. However, the end results were quite different. The analyzed results showed that the severe fires lasted for about an hour, while the fires without casualties were put out within 15 min. A well-constructed second layer of defense measures could effectively contain a fire, and an effective third layer of measures could avoid casualties. The death rate of personnel can be reduced from a dozen to zero, and the burning time is also greatly reduced. The results could be used as a reference for emergency measures in long-term care institutions.</jats:p