Mechanical behavior of spiral reinforcement recycled aggregate concrete round columns under axial compression after spraying water at high temperatures

Spiral hoops can effectively enhance the load-bearing capacity of recycled aggregate concrete columns, and the mechanical performance of such a member after experiencing fire and a fire sprinkler is very important for its application and promotion. Aiming at this problem, the mechanical behavior of spiral reinforcement recycled aggregate concrete round columns under axial compression after spraying water at high temperatures cooling was investigated. Three parameters including recycled coarse aggregate replacement ratio, temperature, and pitch of screw stirrups were taken into consideration. 26 specimens were designed for static loading test. The failure modes of regenerated concrete columns with spiral reinforcement were observed after cooling by high-temperature water spraying. The mechanical properties of specimens under different cooling modes after high temperatures were obtained and analyzed. The results indicate that the effect of the recycled aggregate replacement ratio on the performance of the specimens was mainly in terms of peak displacement. And the reduction in the spiral stirrup spacing increases the peak load and ductility coefficient of the specimens. The high temperature above 600°C has a obvious effect on the mechanical properties of the specimens. Water spray cooling can reduce the appearance of small cracks on the surface of the specimens and their peak displacement. The calculation method of bearing capacity of regenerated spiral reinforced concrete columns cooled by high-temperature water spraying was discussed

Targeting mitophagy for depression amelioration: a novel therapeutic strategy

Major depressive disorder is a global psychiatric condition characterized by persistent low mood and anhedonia, which seriously jeopardizes the physical and mental well-being of affected individuals. While various hypotheses have been proposed to explicate the etiology of depression, the precise pathogenesis and effective treatment of this disorder remain elusive. Mitochondria, as the primary organelles responsible for cellular energy production, possess the ability to meet the essential energy demands of the brain. Research indicated that the accumulation of damaged mitochondria is associated with the onset of depression. Mitophagy, a type of cellular autophagy, specifically targets and removes excess or damaged mitochondria. Emerging evidence demonstrated that mitophagy dysfunction was involved in the progression of depression, and several pharmacological interventions that stimulating mitophagy exerted excellent antidepressant actions. We provided an overview of updated advancements on the regulatory mechanism of mitophagy and the mitophagy abnormality in depressed patients and animals, as well as in cell models of depression. Meanwhile, various therapeutic strategies to restore mitophagy for depression alleviation were also discussed in this review