Selfish traffic allocation for server farms

We study the price of selfish routing in noncooperative networks like the Internet. In particular, we investigate the price of selfish routing using the price of anarchy (a.k.a. the coordination ratio) and other (e.g., bicriteria) measures in the recently introduced game theoretic parallel links network model of Koutsoupias and Papadimitriou. We generalize this model toward general, monotone families of cost functions and cost functions from queueing theory. A summary of our main results for general, monotone cost functions is as follows: 1. We give an exact characterization of all cost functions having a bounded/unbounded price of anarchy. For example, the price of anarchy for cost functions describing the expected delay in queueing systems is unbounded. 2. We show that an unbounded price of anarchy implies an extremely high performance degradation under bicriteria measures. In fact, the price of selfish routing can be as high as a bandwidth degradation by a factor that is linear in the network size. 3. We separate the game theoretic (integral) allocation model from the (fractional) flow model by demonstrating that even a very small or negligible amount of integrality can lead to a dramatic performance degradation. 4. We unify recent results on selfish routing under different objectives by showing that an unbounded price of anarchy under the min-max objective implies an unbounded price of anarchy under the average cost objective and vice versa. Our special focus lies on cost functions describing the behavior of Web servers that can open only a limited number of Transmission Control Protocol (TCP) connections. In particular, we compare the performance of queueing systems that serve all incoming requests with servers that reject requests in case of overload. Our analysis indicates that all queueing systems without rejection cannot give any reasonable guarantee on the expected delay of requests under selfish routing even when the injected load is far away from the capacity of the system. In contrast, Web server farms that are allowed to reject requests can guarantee a high quality of service for every individual request stream even under relatively high injection rates

Integrated epidemiology for vector-borne zoonoses

The development and application of interventions for the control of vector-borne zoonoses requires broad understanding of epidemiological linkages between vector, animal infection and human infection. However, there are significant gaps in our understanding of these linkages and a lack of appropriate data poses a considerable barrier to addressing this issue. A move towards strengthened surveillance of vectors and disease in both animal and human hosts, in combination with linked human-animal surveys, could form the backbone for epidemiological integration, enabling explicit assessment of the animal-human (and vector) interface, and subsequent implications for spill-over to human populations. Currently available data on the spatial distribution of human African trypanosomiasis allow an illustrative example

Influence of cell surface and nanomechanical properties on the flocculation ability of industrial <i>Saccharomyces cerevisiae</i> strains

In the past few years, atomic force microscopy (AFM) has provided novel information on the ultrastructural and nanomechanical properties of yeast cell walls that play a major role in determining the flocculation characteristics of the yeasts. In this study, we used AFM to visualize at the nanoscale the cell surface topography and to determine cell wall nanomechanical properties (e.g. elasticity) of different strains of S. cerevisiae employed for brewing, winemaking and fuel alcohol production. Cell surface topography was found to correlate with the flocculation behaviour of these strains during their late stationary phase, with the cell surface of flocculent cells being rougher than that of weakly flocculent cells. The elastic modulus of the yeast cell walls showed that weakly flocculent strains had a more rigid cell wall than highly flocculent strains. This difference in elasticity seemed to have an effect on the adhesive properties of the yeast cell walls, with weakly flocculent yeasts displaying higher adhesion energy than the highly flocculent strains. These findings seem to indicate that yeast cell surface nanomechanical properties play an important role in governing flocculation

Women’s Experiences with Postpartum Anxiety: Expectations, Relationships, and Sociocultural Influences

Evidence about anxiety in the postpartum is sparse and contradictory. Our research expands this knowledge by using a qualitative methodology, the Feminist Biographical Method, to explore first time mothers’ experiences of postpartum anxiety. Data collection included 1.5 to 2.0 hour interviews with six women about their experiences of anxiety in their transition to motherhood. We transcribed the interviews and used an iterative hermeneutic coding process to develop themes and subthemes over the course of four coding cycles. The findings include five major themes: (a) experiences of anxiety, (b) expectations of a new mother, (c) issues of support, (d) societal scripts of motherhood, and (e) the transition. One conclusion that we draw is the need for healthcare professionals to provide improved support and validation to new mothers facing postpartum anxiety, by expanding the definition of postpartum distress, especially anxiety, and by better understanding women’s anxiety through culturally - embedded contextual and relational lenses

Political representation in Britain is becoming more diverse; political engagement less so

The Equality and Human Rights Commission have a statutory duty to regularly report on the state of human rights and equality in the UK. Based on the Commission’s latest review, ‘Is Britain Fairer?’, Janna Miletzki and Hazel Wardrop write that while formal political representation is more diverse than in 2010, the findings for informal participation are mixe

Modelling environmental factors correlated with podoconiosis: a geospatial study of non-filarial elephantiasis

Introduction The precise trigger of podoconiosis — endemic non-filarial elephantiasis of the lower legs — is unknown. Epidemiological and ecological studies have linked the disease with barefoot exposure to red clay soils of volcanic origin. Histopathology investigations have demonstrated that silicon, aluminium, magnesium and iron are present in the lower limb lymph node macrophages of both patients and non-patients living barefoot on these clays. We studied the spatial variation (variations across an area) in podoconiosis prevalence and the associated environmental factors with a goal to better understanding the pathogenesis of podoconiosis. Methods Fieldwork was conducted from June 2011 to February 2013 in 12 kebeles (administrative units) in northern Ethiopia. Geo-located prevalence data and soil samples were collected and analysed along with secondary geological, topographic, meteorological and elevation data. Soil data were analysed for chemical composition, mineralogy and particle size, and were interpolated to provide spatially continuous information. Exploratory, spatial, univariate and multivariate regression analyses of podoconiosis prevalence were conducted in relation to primary (soil) and secondary (elevation, precipitation, and geology) covariates. Results Podoconiosis distribution showed spatial correlation with variation in elevation and precipitation. Exploratory analysis identified that phyllosilicate minerals, particularly clay (smectite and kaolinite) and mica groups, quartz (crystalline silica), iron oxide, and zirconium were associated with podoconiosis prevalence. The final multivariate model showed that the quantities of smectite (RR = 2.76, 95% CI: 1.35, 5.73; p = 0.007), quartz (RR = 1.16, 95% CI: 1.06, 1.26; p = 0.001) and mica (RR = 1.09, 95% CI: 1.05, 1.13; p < 0.001) in the soil had positive associations with podoconiosis prevalence. Conclusions More quantities of smectite, mica and quartz within the soil were associated with podoconiosis prevalence. Together with previous work indicating that these minerals may influence water absorption, potentiate infection and be toxic to human cells, the present findings suggest that these particles may play a role in the pathogenesis of podoconiosis and acute adenolymphangitis, a common cause of morbidity in podoconiosis patients