Anmerkungen zum Weinstein

Christian Renggli hat unter der Leitung von T. Armbruster, Bern, eine Bachelor-Arbeit mit dem Titel „Mineralogische Untersuchungen an Weinstein“ angefertigt, die sich ausführlich mit den 3 häufigsten Weinsteinsorten befasst. Dieser Arbeit möchte ich nur wenig hinzufügen

Crystal structure of manganese gallium germanium silicon oxide (garnet type), Mn-3(Ga2-yMny)(Ge3-zSiz)O-12 (y=0.6, z=0.14; y=0.44, z=0), and of manganese gallium germanium silicon oxide (braunite type), Mn(Mn6-yGay)(Si1-zGez)O-12 (y=0.7, z=0.4)

Ga1.4Ge2.86Mn3.6O12Si0.14 (1), cubic, Ia3d (No. 230), a = 12.043(3) Angstrom, V = 1746.6 Angstrom(3), Z = 8, R-gt(F) = 0.028, wR(ref)(F-2) = 0.062, T = 300 K. Ga1.56Ge3Mn3.44O12 (2), cubic, Ia3d (No. 230), a = 12.049(3) Angstrom, V = 1749.3 Angstrom(3), Z = 8, R-gt(F) = 0.023, wR(ref)(F-2) = 0.052, T = 300 K. Ga0.7Ge0.4Mn6.3O12Si0.6 (3), tetragonal, I4(1)/acd (No. 142), a = 9.464(4) Angstrom, c = 18.78(3) Angstrom, V = 1682.1 Angstrom(3), Z = 8, R-gt(F) = 0.023, wR(ref)(F-2) = 0.053, T = 300 K

Atypical presentation of neuronal ceroid lipofuscinosis type 8 in a sibling pair and review of the eye findings and neurological features.

Purpose:To report atypical presentation of neuronal ceroid lipofuscinoses type 8 (CLN8) to the eye clinic and review clinical features of CLN8. Observations:Detailed eye exam by slit lamp exam, indirect ophthalmoscopy, fundus photography, optical coherence tomography, visual fields and electroretinogram (ERG). Molecular genetic testing using Next Generation Sequencing panel (NGS) and array Comparative Genomic Hybridization (aCGH).The siblings in this study presented to the eye clinic with retinitis pigmentosa and cystoid macular edema, and a history of seizures but no severe neurocognitive deficits or regression. Genetic testing identified a c.200C > T (p.A67V) variant in the CLN8 gene and a deletion encompassing the entire gene. Electron microscopy of lymphocytes revealed fingerprint inclusions in both siblings. Conclusions:and Importance: Pathogenic variants in CLN8 account for the retinitis pigmentosa and seizures in our patients however, currently, they do not have regression or neurocognitive decline. The presentation of NCL can be very diverse and it is important for ophthalmologists to consider this in the differential diagnosis of retinal disorders with seizures or other neurological features. Molecular genetic testing of multiple genes causing isolated and syndromic eye disorders using NGS panels and aCGH along with additional complementary testing may often be required to arrive at a definitive diagnosis

High yield synthesis and structures of some achiral and chiral (diphosphine)tetracarbonylchromium(0) chelate complexes with tetracarbonyl(norbornadiene)chromium(0) as complexation reagent

Tetracarbonyl(norbornadiene)chromium(0) was used as complexation reagent in the synthesis of tetracarbonylchromium chelate complexes of dppe, dppb, dppf, DIOP, BINAP, and Tol-BINAP. In all cases the reactions took place under mild reaction conditions with excellent, almost quantitative yields. X-ray crystal structure analyses of the dppf and BINAP tetracarbonylchromium(0) complexes are presented.DF

Die Kristallstruktur der orientierungsfehlgeordneten kubischen Hochtemperaturphase des Natriumperchlorats NaClO4

The crystal structure of the orientationally disordered, cubic high-temperature phase of NaC104 has been investigated using single crystal X-ray diffraction data. Space group Fm3m-O5h, Z = 4, sodium and chlorine as in NaCl, oxygen in position 96 j (occupation factor 1/6)

Polymer-bound haloate(I) anions by iodine(III)-mediated oxidation of polymer-bound iodide: Synthetic utility in natural product transformations

A set of polymer-attached hypervalent iodate(I) complexes were prepared from polymer-bound iodide anion by ligand transfer of acetate and trifluoro acetate present in the corresponding iodine(III) reagents onto the iodide anion. The synthetic versatility of these polymer-bound reagents in terms of efficacy and ease of workup is demonstrated for selected examples in natural product synthesis and natural product derivatization. Thus, iodoacetoxylation of glycals is the initial step for the preparation of two deoxygenated disaccharides which are part of the carbohydrate units of the landomycins. In a second example, a one-pot multistep rearrangement of the decanolide decarestrictine D backbone is shown which is initiated by iodotrifluoroacylation of the olefinic double bond.Fonds der Chemischen Industri

Physiologic s100b concentrations reduces glucose uptake in c6 astroglial cells

Astrocytes are the most common cells present in the brain and they are responsible for metabolic support, characterized mainly for their close interaction with neurons. Some glial markers are well recognized, as S100B, a calcium binding protein that plays important intra and extracellular roles in central nervous system. This protein is implicated in glial-neuron communication, presenting neurotrophic or neurotoxic properties, depending on its concentration. Among the models available to study astrocytes, C6 glioma cells in later than 100 passages are very useful, because have properties that are characteristic of the glial cells. The objective of the present work is to evaluate the effect of physiological concentration of exogenous S100B on glucose uptake in C6 astroglial cells. We observed a reduction of glucose uptake in the presence of exogenous S100B, and the incubation with anti-S100B antibody reversed this effect. The incubation with anti-RAGE antibody also reversed this effect, demonstrating that this receptor is involved in the S100B effect. However, further studies are necessary to unveil the S100B mechanism of action

Alimentador automático para animais de pequeno porte

Este projeto visa automatizar o processo de alimentação de animais de pequeno porte para proprietários de animais que não tenham disponibilidade de se manter em suas residências durante todo o dia. O alimentador proporciona a opção de alimentar o pet diariamente com a quantidade especificada pelo proprietário e agendar horários para ativação do alimentador, juntamente com a quantidade que será distribuída para o pet. Este agendamento é feito através de uma página web de fácil acesso e intuitiva. O projeto faz uso de dois principais agentes: um microcontrolador ESP32, que gerencia a criação da página web e armazena os horários de alimentação determinados pelo usuário, e um motor de passo que, como atuador, fará a distribuição do alimento de acordo com as determinações do usuário. Neste projeto, o motor atuador é controlado pelo microcontrolador através de um firmware desenvolvido em linguagem C++.This project aims to automate the feeding process for small pets for pet owners who are not able to stay at home throughout the day. The feeder provides the option to feed the pet automatically with the specified amount set by the owner and to schedule feeding times along with the amount to be dispensed for the pet. This scheduling is done through an easy-to-access and intuitive web page. The project utilizes two main components: an ESP32 microcontroller, which manages the creation of the web page and stores the feeding times set by the user, and a stepper motor that, as an actuator, will dispense the food according to the user’s specifications. In this project, the actuator motor is controlled by the microcontroller through firmware developed in C++ language