Correlation and entanglement of two-component Bose-Einstein condensates in a double well

We consider a novel system of two-component atomic Bose-Einstein condensate in a double-well potential. Based on the well-known two-mode approximation, we demonstrate that there are obvious avoided level-crossings when both interspecies and intraspecies interactions of two species are increased. The quantum dynamics of the system exhibits revised oscillating behaviors compared with a single component condensate. We also examine the entanglement of two species. Our numerical calculations show the onset of entanglement can be signed as a violation of Cauchy-Schwarz inequality of second-order cross correlation function. Consequently, we use Von Neumann entropy to quantity the degree of entanglement

Numerical and theoretical studies of the buckling of shape memory tape spring

By using the high froze/recovery strains of shape memory polymers to meet the requirements of deployable space structures, the folding behavior of shape memory tape spring structures consisting of shape memory polymer and metal spring was analyzed. Firstly, numerical simulations were performed on the buckling modes and affecting factors under the equal- and opposite-sense bends. The results show that the folding deformations of such structure in the two cases are completely different. The equal-sense bending leads to the structure buckled abruptly, but gradual torsion buckling is received in the case of opposite-sense bending. The critical bending moments have big difference in the two cases, and the structure response is strongly dependant on the geometric parameters. Secondly, the critical buckling solution under pure bending was derived, and the result confirms to be agreeable with the finite element calculation

Identification of novel maize miRNAs by measuring the precision of precursor processing

<p>Abstract</p> <p>Background</p> <p>miRNAs are known to play important regulatory roles throughout plant development. Until recently, nearly all the miRNAs in maize were identified by comparative analysis to miRNAs sequences of other plant species, such as rice and <it>Arabidopsis</it>.</p> <p>Results</p> <p>To find new miRNA in this important crop, small RNAs from mixed tissues were sequenced, resulting in over 15 million unique sequences. Our sequencing effort validated 23 of the 28 known maize miRNA families, including 49 unique miRNAs. Using a newly established criterion, based on the precision of miRNA processing from precursors, we identified 66 novel miRNAs in maize. These miRNAs can be grouped into 58 families, 54 of which have not been identified in any other species. Five new miRNAs were validated by northern blot. Moreover, we found targets for 23 of the 66 new miRNAs. The targets of two of these newly identified miRNAs were confirmed by 5'RACE.</p> <p>Conclusion</p> <p>We have implemented a novel method of identifying miRNA by measuring the precision of miRNA processing from precursors. Using this method, 66 novel miRNAs and 50 potential miRNAs have been identified in maize.</p

The Fur Transcription Regulator and Fur-Regulated Genes in Clostridium botulinum A ATCC 3502

Clostridium botulinum is a spore-forming bacterium that can produce a very powerful neurotoxin that causes botulism. In this study, we have investigated the Fur transcription regulators in Clostridium botulinum and Fur-regulated genes in Clostridium botulinum A ATCC 3502. We found that gene loss may be the main cause leading to the different numbers of Fur transcription regulators in different Clostridium botulinum strains. Meanwhile, 46 operons were found to be regulated by the Fur transcription regulator in Clostridium botulinum A ATCC 3502, involved in several functional classifications, including iron acquisition, iron utilization, iron transport, and transcription regulator. Under an iron-restricted medium, we experimentally found that a Fur transcription regulator (CBO1372) and two operons (DedA, CBO2610–CBO2614 and ABC transporter, CBO0845–CBO0847) are shown to be differentially expressed in Clostridium botulinum A ATCC 3502. This study has provided-us novel insights into the diversity of Fur transcription regulators in different Clostridium botulinum strains and diversity of Fur-targeted genes, as well as a better understanding of the dynamic changes in iron restriction occurring in response to this stress

Road Side Unit-Assisted Learning-Based Partial Task Offloading for Vehicular Edge Computing System

The rapid development of vehicular networks creates diverse ultra-low latency constrained and computation-intensive applications, which bring challenges to both communication and computation capabilities of the vehicles and their transmission. By offloading tasks to the edge servers or vehicles in the neighbourhood, vehicular edge computing (VEC) provides a cost-efficient solution to this problem. However, the channel state information and network structure in the vehicular network varies fast because of the inherent mobility of vehicle nodes, which brings an extra challenge to task offloading. To address this challenge, we formulate the task offloading in vehicular network as a multi-armed bandit (MAB) problem and propose a novel road side unit (RSU)-assisted learning-based partial task offloading (RALPTO) algorithm. The algorithm enables vehicle nodes to learn the delay performance of the service provider while offloading tasks. Specifically, the RSU could assist the learning process by sharing the learning information among vehicle nodes, which improves the adaptability of the algorithm to the time-varying networks. Simulation results demonstrate that the proposed algorithm achieves lower delay and better learning performance compared with the benchmark algorithms

The symbiotic bacteria Alcaligenes faecalis of the entomopathogenic nematodes Oscheius spp. exhibit potential biocontrol of plant- and entomopathogenic fungi

Soil-dwelling entomopathogenic nematodes (EPNs) kill arthropod hosts by injecting their symbiotic bacteria into the host hemolymph and feed on the bacteria and the tissue of the dying host for several generations cycles until the arthropod cadaver is completely depleted. The EPN-bacteria-arthropod cadaver complex represents a rich energy source for the surrounding opportunistic soil fungal biota and other competitors. We hypothesized that EPNs need to protect their food source until depletion and that the EPN symbiotic bacteria produce volatile and non-volatile exudations that deter different soil fungal groups in the soil. We isolated the symbiotic bacteria species (Alcaligenes faecalis) from the EPN Oscheius spp. and ran infectivity bioassays against entomopathogenic fungi (EPF) as well as against plant pathogenic fungi (PPF). We found that both volatile and non-volatile symbiotic bacterial exudations had negative effects on both EPF and PPF. Such deterrent function on functionally different fungal strains suggests a common mode of action of A.faecalis bacterial exudates, which has the potential to influence the structure of soil microbial communities, and could be integrated into pest management programs for increasing crop protection against fungal pathogens

Study on the mechanism of liver cancer immune escape mediated by MINDY1 through regulation of PD-L1 ubiquitination level

The novel deubiquitinase enzyme, motif interacting with ubiquitin-containing novel DUB family-1 (MINDY1), is highly expressed in liver cancer tissues and plays a crucial role in maintaining the stemness of liver cancer cells. Programmed death ligand-1 (PD-L1) is an immunosuppressive molecule overexpressed by tumour cells. The potential role of MINDY1 in inhibiting the stemness of liver cancer cells by deubiquitinating PD-L1 has not yet been reported. To investigate the mechanism by which MINDY1 mediates immune escape in liver cancer through the regulation of PD-L1 ubiquitination, we examined the expression levels of MINDY1 and PD-L1 in liver cancer and adjacent tissues from 50 hepatocellular carcinoma (HCC) patients using protein imprinting and immunohistochemistry. We analyzed the relationship between the expression levels of MINDY1 and PD-L1 in liver cancer tissues and their correlation with the 5-year tumor-free survival rates of patients. Subsequently, MINDY1 expression was knocked down in Huh7 cells using small interfering RNA (siRNA) interference or upregulated through transfection with a MINDY1 overexpression plasmid. The effects of MINDY1 knockdown or overexpression on the proliferation, apoptosis, migration, and invasion of HCC cells, as well as the regulation of PD-L1 binding and ubiquitination, were assessed. The 5-year tumor-free survival rates were significantly lower in both the high MINDY1 expression group and the high PD-L1 expression group (χ2 = 4.919 and 13.158, respectively). A significant difference in survival was observed between the high and low MINDY1 expression groups (χ2= 27.415). MINDY1 was found to directly interact with PD-L1, with MINDY1 gene knockdown promoting PD-L1 ubiquitination and MINDY1 overexpression inhibiting PD-L1 ubiquitination. All comparisons yielded statistically significant results (P < 0.05). In conclusion, MINDY1 inhibits the malignant progression of liver cancer by inhibiting PD-L1 ubiquitination and mediating immune escape

Thermal-dephasing-tolerant generation of mesoscopic superposition states with Rydberg dressed blockade

Multipartite entangled states involving non-locality are one of the most fascinating characteristics of quantum mechanics. In this work, we propose a thermal-dephasing-tolerant generation of mesoscopic entangled states with Rydberg dressed atoms. We encode logical state on dressed states rather than Rydberg states. Such treatment can increase the lifetime of multipartite entanglement coherence to around 3 times compared to the Rydberg-state-coding one at the same system size, and therefore induce solid fidelities of mesoscopic superposition states generation. The current work theoretically verifies the advantages of using Rydberg dressed states in many-body quantum entan-glement, which is helpful for large-scale quantum computation and many-body Rydberg quantum simulation

Causal relationship between the gut microbiota, immune cells, and coronary heart disease: a mediated Mendelian randomization analysis

BackgroundRecent studies have shown that the gut microbiota (GM), immune cells, and coronary heart disease (CHD) are closely related, but the causal nature of these relationships is largely unknown. This study aimed to investigate this causal relationship and reveal the effect of GM and immune cells on the risk of developing CHD using mediated Mendelian randomization (MR) analysis.MethodsFirst, we searched for data related to GM, immune cells, and CHD through published genome-wide association studies (GWAS). We filtered the single nucleotide polymorphisms (SNPs) associated with GM and immune cells and then performed the first MR analysis to identify disease-associated intestinal bacteria and disease-associated immune cells. Subsequently, three MR analyses were conducted: from disease-associated GM to disease-associated immune cells, from disease-associated immune cells to CHD, and from disease-associated GM to CHD. Each MR analysis was conducted using inverse variance weighting (IVW), MR-Egger regression, weighted median, weighted models, and simple models.ResultsA total of six GM and 25 immune cells were found to be associated with CHD. In the MR analysis using the inverse variance weighting (IVW) method, g__Desulfovibrio.s__Desulfovibrio_piger was associated with EM DN (CD4–CD8–) %T cells (P &lt; 0.05 and OR &gt; 1), EM DN (CD4–CD8–) %T cells was associated with CHD (P &lt; 0.05 and OR &lt; 1), and g__Desulfovibrio.s__Desulfovibrio_piger was associated with CHD (P &lt; 0.05 and OR &lt; 1).ConclusionAn increase in the abundance of g__Desulfovibrio.s__Desulfovibrio_piger leads to an increase in the amount of EM DN (CD4–CD8–) %T cells, and an increase in the amount of EM DN (CD4–CD8–) %T cells reduces the risk of developing CHD. Our study provides some references for reducing the incidence of CHD by regulating GM and immune cells