К вопросу об исследовании прочностных характеристик корпуса выбивной машины и динамических процессов при выбивке отливок

У статті запропоновано обґрунтування раціональних розрахунково-експериментальних параметрів вибивальної машини. Наводяться уточнені результати визначення параметрів, що відповідають за міцність та динамічні характеристики. Результати наведені у вигляді графіків та картин розподілу переміщень, деформацій та напружень.The groundings of rational computational-experimental parameters of shake-out-machine are given in the article. The specified results of parameter determinationthat are responsible for strength and dynamic characteristics are given. Results are presented as the graphs and pictures of distribution of displacements, deformations and stresses

The Classification of Weld Seam Defects for Quantitative Analysis by means of Ultrasonic Testing

The paper describes effective quality assessment of spent nuclear fuel storage cask. The ultrasonic testing method is considered. The classification of possible defects with corresponding dimensions limits is proposed. The database of defects of the spent nuclear fuel storage cask was created in compliance with the nuclear energy industry regulatory documents

Genomic Characterization of Cholangiocarcinoma in Primary Sclerosing Cholangitis Reveals Therapeutic Opportunities

Background and Aims Lifetime risk of biliary tract cancer (BTC) in primary sclerosing cholangitis (PSC) may exceed 20%, and BTC is currently the leading cause of death in patients with PSC. To open new avenues for management, we aimed to delineate clinically relevant genomic and pathological features of a large panel of PSC-associated BTC (PSC-BTC). Approach and Results We analyzed formalin-fixed, paraffin-embedded tumor tissue from 186 patients with PSC-BTC from 11 centers in eight countries with all anatomical locations included. We performed tumor DNA sequencing at 42 clinically relevant genetic loci to detect mutations, translocations, and copy number variations, along with histomorphological and immunohistochemical characterization. Regardless of the anatomical localization, PSC-BTC exhibited a uniform molecular and histological characteristic similar to extrahepatic cholangiocarcinoma. We detected a high frequency of genomic alterations typical of extrahepatic cholangiocarcinoma, such asTP53(35.5%),KRAS(28.0%),CDKN2A(14.5%), andSMAD4(11.3%), as well as potentially druggable mutations (e.g.,HER2/ERBB2). We found a high frequency of nontypical/nonductal histomorphological subtypes (55.2%) and of the usually rare BTC precursor lesion, intraductal papillary neoplasia (18.3%). Conclusions Genomic alterations in PSC-BTC include a significant number of putative actionable therapeutic targets. Notably, PSC-BTC shows a distinct extrahepatic morpho-molecular phenotype, independent of the anatomical location of the tumor. These findings advance our understanding of PSC-associated cholangiocarcinogenesis and provide strong incentives for clinical trials to test genome-based personalized treatment strategies in PSC-BTC.Peer reviewe

The Mass Distribution of White Dwarfs and Central Stars of Planetary Nebulae

Recent results on mass distributions for white dwarfs and planetary nebulae are presented and compared with current theoretical predictions. Whereas single star evolution leads to final masses predominantely in a narrow interval around 0.6μ0 which can be explained by current mass loss schemes degenerate stars in binaries present a larger range of masses. The average mass of the primaries in cataclysmic binaries seems to be more around 0.7 than 1μ0.</jats:p