Address by Judge Edward Weinfeld

This is a transcript of Judge Edward Weinfeld\u27s acceptance of the 1985 Fordham Stein Award

Characteristics of the dynamics of breakdown filaments in Al2O3/InGaAs stacks

In this paper, the Al2O3/InGaAs interface was studied by X-ray photoelectron spectroscopy (XPS) after a breakdown (BD) event at positive bias applied to the gate contact. The dynamics of the BD event were studied by comparable XPS measurements with different current compliance levels during the BD event. The overall results show that indium atoms from the substrate move towards the oxide by an electro-migration process and oxidize upon arrival following a power law dependence on the current compliance of the BD event. Such a result reveals the physical feature of the breakdown characteristics of III-V based metal-oxide-semiconductor devices.Fil: Palumbo, Félix Roberto Mario. Comisión Nacional de Energía Atómica; Argentina. Universidad Tecnológica Nacional; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Shekhter, P.. Technion - Israel Institute of Technology; IsraelFil: Cohen Weinfeld, K.. Technion - Israel Institute of Technology; IsraelFil: Eizenberg, M.. Technion - Israel Institute of Technology; Israe

Why do SGLT2 inhibitors reduce heart failure hospitalization? A differential volume regulation hypothesis

The effect of a sodium glucose cotransporter 2 inhibitor (SGLT2i) in reducing heart failure hospitalization in the EMPA-REG OUTCOMES trial has raised the possibility of using these agents to treat established heart failure. We hypothesize that osmotic diuresis induced by SGLT2 inhibition, a distinctly different diuretic mechanism than other diuretic classes, results in greater electrolyte-free water clearance, and ultimately in greater fluid clearance from the interstitial fluid (IF) space than from the circulation, potentially resulting in congestion relief with minimal impact on blood volume, arterial filling, and organ perfusion. We utilize a mathematical model to illustrate that electrolyte-free water clearance results in a greater reduction in IF volume compared to blood volume, and that this difference may be mediated by peripheral sequestration of osmotically inactive sodium. By coupling the model with data on plasma and urinary sodium and water in healthy subjects administered either the SGLT2i dapagliflozin or loop diuretic bumetanide, we predict that dapagliflozin produces a 2-fold greater reduction in IF volume compared to blood volume, while the reduction in IF volume with bumetanide is only 78% of the reduction in blood volume. Heart failure is characterized by excess fluid accumulation, in both the vascular compartment and interstitial space, yet many heart failure patients have arterial underfilling due to low cardiac output, which may be aggravated by conventional diuretic treatment. Thus, we hypothesize that by reducing IF volume to a greater extent than blood volume, SGLT2 inhibitors might provide better control of congestion without reducing arterial filling and perfusion

MESURE DES GRADIENTS DE DENSITÉ DANS L'INTERACTION LASER-PLASMA

Nous étudions la densité électronique et son gradient dans l'interaction d'un laser à CO2 avec une cible plane de polyéthylène, pour un flux laser de 1012 W/cm2. L'étude par interférométrie Jamin des profils de densité et la mesure strioscopique de son gradient, couplées à l'étude de l'image en rayons X du plasma conduisent à une valeur de 220 ± 80 µm de la longueur du gradient de densité. Ceci est confirmé par des mesures indirectes obtenues à partir du bilan optique de l'interaction et du seuil de génération de l'harmonique 3/2 ω0 du laser à CO2. Les conséquences de ces résultats sur les conditions de l'interaction sont discutées

Enhancing Semantic Search with Human-Crafted Knowledge in Sentence Embeddings

Semantic search plays a critical role in many domains, with numerous algorithms developed to address it. A common approach involves using sentence transformers to generate embeddings for both search queries and documents, allowing for the comparison of their vectors. While many different embedding models are widely used, our approach integrates these models with human-crafted knowledge in a novel way, resulting in an improvement in the Mean Average Precision (MAP) scores. Traditional embeddings often rely heavily on the specific words used in a query or document. Our technique mitigates this dependency by refining the vectors to capture the overall semantic meaning, shifting the focus from individual words to the broader concepts they represent. This approach highlights the importance of semantic understanding in search tasks. In our experiments, using 23 different sentence embedding models, we achieved a statistically significant improvement in MAP scores, with a p-value of 0.047

Can targeting preventive care reminders to primary care providers seeing their own patients improve response to clinical decision support?

Electronic health records EHRs have the potential to improve measurability and quality of care but excess alerting may reduce alert response through alert fatigue. To understand if targeting of alerts to primary care providers PCPs may be of value in decreasing alert fatigue we looked at the extent and accuracy of PCP identification within one organization-shared EHR and providers clinical decision support CDS use. We hypothesized that PCP identification in the system would vary by site would be accurate and that a PCP's response to alerts would be highest during a provider's primary care visits with their patients and lower when seeing a colleague's patients