The Effect of Music on the Social Behavior of a Child with Autism Spectrum Disorder

Autism Spectrum Disorder (ASD) is defined by the American Speech-Language Hearing Association as a developmental disability that causes problems with social skills and communication. The principle objective of this case study was to determine whether or not listening to music affects the social behaviors of a child with ASD. In addition, this study sought to determine if listening to different types of music caused a difference in the social behaviors of the child. Two types of music, nursery rhymes and classical instrumental, were used and four specific social behaviors; eye contact, joint attention, facial expressions, and attention seeking; were examined. Five minutes of listening to music was implemented at the beginning of each therapy session. The two musical types were alternated monthly over a semester of therapy. This study could have implications for future use of music in the treatment of social behaviors in children with ASD

Nucleosome conformation dictates the histone code

Histone post-translational modifications (PTMs) play a critical role in chromatin regulation. It has been proposed that these PTMs form localized ‘codes’ that are read by specialized regions (reader domains) in chromatin-associated proteins (CAPs) to regulate downstream function. Substantial effort has been made to define [CAP: histone PTM] specificities, and thus decipher the histone code and guide epigenetic therapies. However, this has largely been done using the reductive approach of isolated reader domains and histone peptides, which cannot account for any higher-order factors. Here, we show that the [BPTF PHD finger and bromodomain: histone PTM] interaction is dependent on nucleosome context. The tandem reader selectively associates with nucleosomal H3K4me3 and H3K14ac or H3K18ac, a combinatorial engagement that despite being in cis is not predicted by peptides. This in vitro specificity of the BPTF tandem reader for PTM-defined nucleosomes is recapitulated in a cellular context. We propose that regulatable histone tail accessibility and its impact on the binding potential of reader domains necessitates we refine the ‘histone code’ concept and interrogate it at the nucleosome level