Improving transparency and scientific rigor in academic publishing.

Progress in basic and clinical research is slowed when researchers fail to provide a complete and accurate report of how a study was designed, executed, and the results analyzed. Publishing rigorous scientific research involves a full description of the methods, materials, procedures, and outcomes. Investigators may fail to provide a complete description of how their study was designed and executed because they may not know how to accurately report the information or the mechanisms are not in place to facilitate transparent reporting. Here, we provide an overview of how authors can write manuscripts in a transparent and thorough manner. We introduce a set of reporting criteria that can be used for publishing, including recommendations on reporting the experimental design and statistical approaches. We also discuss how to accurately visualize the results and provide recommendations for peer reviewers to enhance rigor and transparency. Incorporating transparency practices into research manuscripts will significantly improve the reproducibility of the results by independent laboratories

The Headscarf Effect Revisited:Further Evidence for a Culture-Based Internal Face Processing Advantage

© 2015 a Pion publication. Encoding the internal features of unfamiliar faces poses a perceptual challenge that occasionally results in face recognition errors. Extensive experience with faces framed by a headscarf may, however, enhance perceivers’ ability to process internal facial information. To examine this claim empirically, participants in the United Arab Emirates and the United States of America completed a standard part-whole face recognition task. Accuracy on the task was examined using a 2 (perceiver culture: Emirati vs American) × 2 (face race: Arab vs white) × 2 (probe type: part vs whole) × 3 (probe feature: eyes vs nose vs mouth) mixed-measures analysis of variance. As predicted, Emiratis outperformed Americans on the administered task. Although their recognition advantage occurred regardless of probe type, it was most pronounced for Arab faces and for trials that captured the processing of nose or mouth information. The findings demonstrate that culture-based experiences hone perceivers’ face processing skills

Prolonged low flow reduces reactive hyperemia and augments low flow mediated constriction in the brachial artery independent of the menstrual cycle

© 2013 Rakobowchuk et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Non-invasive forearm ischemia-reperfusion injury and low flow induced vascular dysfunction models provide methods to evaluate vascular function. The role of oestrogen, an endogenous anti-oxidant on recovery from ischemia-reperfusion injury has not been evaluated nor has the impact of prolonged low flow on vascular function been established. Eight healthy women (33610 yr) attended the lab during the follicular, ovulatory and mid-luteal phases of their menstrual cycles. After 30 minutes of rest, brachial artery vascular function was assessed by ultrasound measurements of diameter changes during 5 minutes of forearm ischemia and 3 minutes after. Subsequently, a 20-minute forearm ischemia period was completed. Further, vascular function assessments were completed 15, 30 and 45 minutes into recovery. Flow-mediated dilation, lowflow-mediated constriction, and reactive hyperaemia proximal to the area of ischemia were determined. Flow-mediated dilation was reduced at 15 minutes of recovery but recovered at 30 and 45 minutes (PRE: 7.161.0%, POST15:4.560.6%, POST30:5. 560.7% POST45:5.960.4%, p,0.01). Conversely, low-flow mediated constriction increased (PRE: 21.360.4%, POST15: 23.360.6%, POST30: 22.560.5% POST45: 21.560.12%, p,0.01). Reactive hyperaemia was reduced throughout recovery (p,0.05). Data were unaffected by menstrual phase. Prolonged low flow altered vascular function and may relate as much to increased vasoconstriction as with decreased vasodilation. Reductions in anterograde shear and greater retrograde shear likely modulate the brachial artery response, but the reduced total shear also plays an important role. The data suggest substantial alterations in vascular function proximal to areas of ischemia with potential clinical implications following reperfusion.British Heart Foundation (PG/08/060/25340),a Physiological Society summer studentship to SG, and a Wellcome Trust Vacation Studentship to EP

Developing an Effective and Efficient Real Time Strategy Agent for Use as a Computer Generated Force

Computer Generated Forces (CGF) are used to represent units or individuals in military training and constructive simulation. The use of CGF significantly reduces the time and money required for effective training. For CGF to be effective, they must behave as a human would in the same environment. Real Time Strategy (RTS) games place players in control of a large force whose goal is to defeat the opponent. The military setting of RTS games makes them an excellent platform for the development and testing of CGF. While there has been significant research in RTS agent development, most of the developed agents are only able to exhibit good tactical behavior, lacking the ability to develop and execute overall strategies. By analyzing prior games played by an opposing agent, an RTS agent can determine the opponent\u27s strengths and weaknesses and develop a strategy which neutralizes the strengths and capitalizes on the weaknesses. It can then execute this strategy in an RTS game. This research develops such an RTS agent called the Killer Bee Artificial Intelligence (KBAI). KBAI builds a classifier for an opposing RTS agent which allows it to predict game outcomes. It then takes this classifier, uses it to generate an effective counter-strategy, and executes the tactics required for the strategy. KBAI is both effective and efficient against four high-quality scripted agents: it wins 100% of the time, and it wins quickly. When compared to native artificial intelligence, KBAI has superior performance. It exhibits strategic behavior, as well as the tactics required to execute a developed strategy

The value of noncoronary atherosclerosis for identifying coronary artery disease: results of the Leipzig LIFE Heart Study

BACKGROUND: Despite the widespread use of noninvasive testing prior to invasive coronary diagnostic the diagnostic yield of elective coronary angiography has been reported low in subjects with suspected obstructive CAD. OBJECTIVE: To determine the predictive value of noncoronary atherosclerosis (NCA) in subjects with suspected stable coronary artery disease (CAD) intended to invasive coronary angiography. METHODS: Ultrasound-based assessment of carotid artery plaque (CAP), carotid intima-media thickness (CIMT) and ankle-brachial index (ABI) was performed in 2216 subjects with suspected CAD prior to coronary angiography. Logistic regression and c-statistics were used to analyze the diagnostic value of NCA for the presence of obstructive CAD and the intention to revascularization. RESULTS: Percentage of positive results of elective coronary angiography was low but comparable to other studies (41 % obstructive CAD). We identified 1323 subjects (60 %) with NCA, most of them were characterized by CAP (93 %). CAP independently predicted obstructive CAD in addition to traditional risk factors and clinical factors while CIMT and ABI failed to improve the prediction. The presence of NCA and typical angina were the strongest predictors for obstructive CAD (OR 4.0 and 2.4, respectively). A large subgroup of patients (n = 703, 32 %) with atypical clinical presentation and lack of NCA revealed a low indication for revascularization <15 % indicating a large proportion of subjects with non-obstructive CAD in this subgroup. CONCLUSION: The evaluation of noncoronary atherosclerosis has the potential to impact clinical decision making and to direct subsequent diagnostic procedures in subjects with suspected coronary artery disease. CLINICAL TRIAL REGISTRATION: NCT00497887. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00392-015-0900-x) contains supplementary material, which is available to authorized users

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Assessment of arterial function in pregnancy: recommendations of the International Working Group on Maternal Haemodynamics.

There is strong evidence supporting a role of maternal arterial dysfunction in pregnancy-specific disorders such as pre-eclampsia and intra-uterine growth restriction. As more work is focused towards this field, it is important that methods and interpretation of arterial function assessment are utilised appropriately. Here, we summarise techniques and devices commonly used in maternal health studies, with considerations of technical application within pregnant cohorts