A validação da ludicidade como estratégia metodológica ao ensino da tabela periódica

Anais do 35º Seminário de Extensão Universitária da Região Sul - Área temática: EducaçãoO uso de recursos didáticos como ferramenta pedagógica associada a ludicidade, torna o ensino mais prazeroso aos alunos. Nesta perspectiva, os jogos lúdicos, surgem como uma alternativa, pois possibilitam o trabalho em grupos e maior interação docente-discente. Partindo desta concepção, elaborou-se um jogo lúdico denominado ́ ́ Caminho da Química``, que trata de um jogo de tabuleiro em que o jogador terá informações dos elementos químicos da Tabela Periódica. No intuito de analisar a concepção e aceitação dos alunos quanto ao uso de um jogo lúdico para o ensino da Tabela Periódica, aplicou-se um questionário composto por questões de múltipla escolha. O uso do lúdico através do jogo, mostrou ser um recurso didático de ampla aceitação entre os alunos, possibilita maior interação entre os colegas, oportunizando um ambiente descontraído mais prazeroso e oposto ao método tradicional de ensin

The magmatic system beneath the Tristan da Cunha Island: Insights from thermobarometry, melting models and geophysics

This study provides new insights on the conditions of melt generation and of magma transport and storage beneath Tristan da Cunha Island in the South Atlantic. Situated at the seaward end of the Walvis Ridge-guyot hotspot track, this island is related to the evolving magmatic system of the Tristan plume. Much is known about the geochemical and isotopic composition of the alkaline lavas on Tristan, but the pressure-temperature conditions of the hotspot magmas are under-explored. This contribution reports new data from a suite of 10 samples collected during a geologic-geophysical expedition in 2012. The focus of this study is on the least-evolved, phenocryst-rich basanite lavas but we also included a sample of trachyandesite lava erupted in 1961. Mineral-melt equilibrium thermobarometry uses the composition of olivine, clinopyroxene and plagioclase phenocrysts. In addition to bulk-rock data we also analysed olivine-hosted melt inclusions for the P-T calculations. The results for olivine-melt and clinopyroxene-melt calculations suggest crystallization conditions of around 1200-1250. °C and 0.8-1.3. GPa for the least-evolved magmas (ankaramitic basanites). Combined with seismological evidence for a Moho depth of about 19. km, these results imply magma storage and partial crystallization of Tristan magmas in the uppermost mantle and at Moho level. The trachyandesite yielded values of about 1000. °C and 0.2-0.3. GPa (6 to 10. km depth), indicating further crystallization within the crust.Constraints on the depth and degree of melting at the source of Tristan basanites were derived from REE inverse modelling using our new trace element data. The model predicts 5% melt generation from a melting column with its base at 80-100. km and a top at 60. km, which is consistent with the lithospheric thickness resulting from cooling models and seismological observations. The thermobarometry and melting models combined suggest a mantle potential temperature of about 1360. °C for the Tristan hotspot

Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL

T-cell prolymphocytic leukemia (T-PLL) is a rare and poor-prognostic mature T-cell malignancy. Here we integrated large-scale profiling data of alterations in gene expression, allelic copy number (CN), and nucleotide sequences in 111 well-characterized patients. Besides prominent signatures of T-cell activation and prevalent clonal variants, we also identify novel hot-spots for CN variability, fusion molecules, alternative transcripts, and progression-associated dynamics. The overall lesional spectrum of T-PLL is mainly annotated to axes of DNA damage responses, T-cell receptor/cytokine signaling, and histone modulation. We formulate a multi-dimensional model of T-PLL pathogenesis centered around a unique combination of TCL1 overexpression with damaging ATM aberrations as initiating core lesions. The effects imposed by TCL1 cooperate with compromised ATM toward a leukemogenic phenotype of impaired DNA damage processing. Dysfunctional ATM appears inefficient in alleviating elevated redox burdens and telomere attrition and in evoking a p53-dependent apoptotic response to genotoxic insults. As non-genotoxic strategies, synergistic combinations of p53 reactivators and deacetylase inhibitors reinstate such cell death execution.Peer reviewe

Plasma-Functionalized Water: from Bench to Prototype for Fresh-Cut Lettuce

Fresh-cut produce like lettuce may contain a very high microbial load, including human pathogens. Therefore, the need for antimicrobial agents at post-harvest stages to mitigate microbial cross-contamination and growth is evident. Sanitation based on non-thermal plasma (NTP) reveals innovative food processing possibilities by application at different points along the food chain, for production, modification, and preservation, as well as in packaging of plant- and animal-based food. The aim of the present study was to evaluate the applicability of plasma-treated water (PTW) as antimicrobial process water additives for washing in fresh-cut lettuce processing. Antibacterial activities of PTW the natural occurring microflora of lettuce were examined. Different process variants of PTW application inside the washing process were investigated. Fresh-cut lettuce were investigated regarding microbiological safety and food quality. Samples were analyzed for antimicrobial and metabolic activity as well as metabolic vitality to prove food safety. The investigations for food quality included color and texture analyses and nitrate concentration detection in fresh tissue as well as microscopic measurements by scanning electron microscopy (SEM) and atomic force microscopy (AFM) for tissue surface structure and transmission electron microscopy (TEM) for cell organelle investigations. The application of PTW allowed up to 5 log10 cycle reduction, depending on the process variant and scale (lab and pilot scale). The increase of antimicrobial activity was accompanied by a reduction of metabolic activity, but not consequently by a decrease in metabolic vitality. Food quality was not affected by the use of PTW in the washing process of the fresh-cut lettuce. The promising results in color and texture were supported by the results of the microscopic assays. These promising results may lead to an industrial application of PTW as process water additive in fresh-cut produce processing to reduce the microbial load on the food surface and in addition in the process water or on food processing surfaces. © 2020, The Author(s)

The culture in mercosur: an analysis of the developments of the mercosur social summits in the meetings of Ministers of Culture (2006-2015)

O presente artigo tem como objetivo analisar como as propostas formuladas no âmbito das Cúpulas Sociais do MERCOSUL (CSM) para a área da cultura foram incorporadas pelas Reuniões de Ministros da Cultura (RMC). Para tal, identificamos primeiramente as propostas sobre cultura nas CSM entre 2006 e 2015. Em seguida, analisamos como as propostas resultantes das CSM para a área da cultura foram abordadas pelas RMC no mesmo período, buscando identificar projetos e ações estabelecidos a partir de tais demandas e estudar seus desdobramentos. Entre os resultados, o estudo conclui que, apesar das CSM se apresentarem como um importante espaço de participação social, há a necessidade de que existam modos mais efetivos de difusão das propostas aos órgãos do MERCOSUL, além de a tomada de decisões não ficar exclusivamente na intergovernamentalidade, pois isso dificulta a institucionalização.This article aims to analyze how the proposals formulated in the framework of the Social Summits of Mercosur (CSM) for the area of culture have been incorporated by the Meetings of Ministers of Culture (RMC). To this end, we will first identify the proposals in the CSMs between 2006 and 2015. Next, we analyze how the proposals resulting from the CSM for the area of culture were addressed by the MRC in the same period, seeking to identify projects and actions established from such demands and study their unfolding. Among the results, the study concludes that, although the CSMs present themselves as an important space for social participation, there is a need for more effective ways of disseminating proposals to the MERCOSUR bodies, and for decision making not to remain exclusively intergovernmental, since this hinders institutionalization. Este artículo pretende analizar cómo las propuestas formuladas en el marco de las Cumbres Sociales del Mercosur (CSM) para el área de cultura fueron incorporadas por las Reuniones de Ministros de Cultura (RMC). Para ello, en primer lugar, identificamos las propuestas sobre cultura en las CSM entre 2006 y 2015. A continuación, analizamos cómo las propuestas resultantes de la CSM para el área de cultura fueron atendidas por las RMC en el mismo periodo, buscando identificar los proyectos y acciones establecidos a partir de estas demandas y estudiar su desarrollo. Entre los resultados, el estudio concluye que, si bien las CSM son un importante espacio de participación social, se necesitan formas más efectivas de difusión de las propuestas dentro de los órganos del MERCOSUR, y que la toma de decisiones no sea exclusivamente intergubernamental, ya que esto dificulta la institucionalización