The Impact of Workplace Conditions on Firm Performance

This paper estimates the impact of work environment health and safety practice on firm performance, and examines which firm-characteristic factors are associated with good work conditions. We use Danish longitudinal register matched employer-employee data, merged with firm business accounts and detailed cross-sectional survey data on workplace conditions. This enables us to address typical econometric problems such as omitted variables bias or endogeneity in estimating i) standard production functions augmented with work environment indicators and aggregate employee characteristics and ii) firm mean wage regressions on the same explanatory variables. Our findings suggest that improvement in some of the physical dimensions of the work health and safety environment (specifically, “internal climate” and “repetitive and strenuous activity”) strongly impacts the firm productivity, whereas “internal climate” problems are the only workplace hazards compensated for by higher mean wages

Ultrastable lasers based on vibration insensitive cavities

We present two ultra-stable lasers based on two vibration insensitive cavity designs, one with vertical optical axis geometry, the other horizontal. Ultra-stable cavities are constructed with fused silica mirror substrates, shown to decrease the thermal noise limit, in order to improve the frequency stability over previous designs. Vibration sensitivity components measured are equal to or better than 1.5e-11 per m.s^-2 for each spatial direction, which shows significant improvement over previous studies. We have tested the very low dependence on the position of the cavity support points, in order to establish that our designs eliminate the need for fine tuning to achieve extremely low vibration sensitivity. Relative frequency measurements show that at least one of the stabilized lasers has a stability better than 5.6e-16 at 1 second, which is the best result obtained for this length of cavity.Comment: 8 pages 12 figure

Ultraviolet Absorption Spectra at Reduced Temperatures. I. Principles and Methods

Low temperature absorption and fluorescence spectra of solids, liquids, and solutions often reveal increased spectral detail of use in analytical procedures and molecular structure studies. Nevertheless, while qualitative observations of the influence of liquid air temperatures upon optical properties were undertaken very early, investigations of the absorption and fluorescence of organic compounds at the temperature of liquid nitrogen (-195.6°; 77.4 °K.) and below have appeared only sporadically. Because of the potential usefulness of the technique we have undertaken a systematic study of the low temperature spectra of substances of biochemical interest. The present paper discusses the methods employed; subsequent papers will deal with the experimental results. In this work, we have emphasized the wave-length location of absorption bands and the accurate determination of relative optical densities rather than precision in the determination of absolute optical densities, thus permitting the use of simpler methods than would otherwise be necessary

Calibration of the NuSTAR High Energy Focusing X-ray Telescope

We present the calibration of the \textit{Nuclear Spectroscopic Telescope Array} (\nustar) X-ray satellite. We used the Crab as the primary effective area calibrator and constructed a piece-wise linear spline function to modify the vignetting response. The achieved residuals for all off-axis angles and energies, compared to the assumed spectrum, are typically better than $\pm 2$\% up to 40\,keV and 5--10\,\% above due to limited counting statistics. An empirical adjustment to the theoretical 2D point spread function (PSF) was found using several strong point sources, and no increase of the PSF half power diameter (HPD) has been observed since the beginning of the mission. We report on the detector gain calibration, good to 60\,eV for all grades, and discuss the timing capabilities of the observatory, which has an absolute timing of $\pm$ 3\,ms. Finally we present cross-calibration results from two campaigns between all the major concurrent X-ray observatories (\textit{Chandra}, \textit{Swift}, \textit{Suzaku} and \textit{XMM-Newton}), conducted in 2012 and 2013 on the sources 3C\,273 and PKS\,2155-304, and show that the differences in measured flux is within $\sim$10\% for all instruments with respect to \nustar

Exclusive neuronal expression of SUCLA2 in the human brain

SUCLA2 encodes the ATP-forming subunit (A-SUCL-) of succinyl-CoA ligase, an enzyme of the citric acid cycle. Mutations in SUCLA2 lead to a mitochondrial disorder manifesting as encephalomyopathy with dystonia, deafness and lesions in the basal ganglia. Despite the distinct brain pathology associated with SUCLA2 mutations, the precise localization of SUCLA2 protein has never been investigated. Here we show that immunoreactivity of A-SUCL- in surgical human cortical tissue samples was present exclusively in neurons, identified by their morphology and visualized by double labeling with a fluorescent Nissl dye. A-SUCL- immunoreactivity co-localized >99% with that of the d subunit of the mitochondrial F0-F1 ATP synthase. Specificity of the anti-A-SUCL- antiserum was verified by the absence of labeling in fibroblasts from a patient with a complete deletion of SUCLA2. A-SUCL- immunoreactivity was absent in glial cells, identified by antibodies directed against the glial markers GFAP and S100. Furthermore, in situ hybridization histochemistry demonstrated that SUCLA2 mRNA was present in Nissl-labeled neurons but not glial cells labeled with S100. Immunoreactivity of the GTP-forming subunit (G-SUCL-) encoded by SUCLG2, or in situ hybridization histochemistry for SUCLG2 mRNA could not be demonstrated in either neurons or astrocytes. Western blotting of post mortem brain samples revealed minor G-SUCL- immunoreactivity that was however, not upregulated in samples obtained from diabetic versus non-diabetic patients, as has been described for murine brain. Our work establishes that SUCLA2 is expressed exclusively in neurons in the human cerebral cortex

CPN Tools 4: Multi-formalism and Extensibility

Abstract. CPN Tools is an advanced tool for editing, simulating, and analyzing colored Petri nets. This paper discusses the fourth major re-lease of the tool, which makes it simple to use the tool for ordinary Petri nets, including adding inhibitor and reset arcs, and PNML export. This version also supports declarative modeling using constraints, and adds an extension framework making it easy for third parties to extend CPN Tools using Java.

Bursting behavior of the Galactic Center faint X-ray transient GRS 1741.9-2853

The neutron star low-mass X-ray binary GRS 1741.9-2853 is a known type-I burster of the Galactic Center. It is transient, faint, and located in a very crowded region, only 10 arcmin from the supermassive black hole Sgr A*. Therefore, its bursting behavior has been poorly studied so far. In particular, its persistent emission has rarely been detected between consecutive bursts, due to lack of sensitivity or confusion. This is what made GRS 1741.9-2853 one of the nine "burst-only sources" identified by BeppoSAX a few years ago. The physical properties of GRS 1741.9-2853 bursts are yet of great interest since we know very little about the nuclear regimes at stake in low accretion rate bursters. We examine here for the first time several bursts in relation with the persistent emission of the source, using INTEGRAL, XMM-Newton, and Swift observations. We investigate the source flux variability and bursting behavior during its 2005 and 2007 long outbursts. The persistent luminosity of GRS 1741.9-2853 varied between ~1.7 and 10.5 10^36 erg s^-1, i.e. 0.9-5.3% of the Eddington luminosity. The shape of the spectrum as described by an absorbed power-law remained with a photon index Gamma ~ 2 and a column density $N_{\rm H} ~ 12 10^22 cm^-2 throughout the outbursts. We discovered 11 type-I bursts with INTEGRAL, and inspected 4 additional bursts: 2 recorded by XMM-Newton and 2 by Swift. From the brigthest burst, we derive an upper limit on the source distance of ~7 kpc. The observed bursts characteristics and source accretion rate suggest pure helium explosions igniting at column depths y_{ign} ~ 0.8-4.8 10^8 g cm^-1, for typical energy releases of ~1.2-7.4 10^39 erg.Comment: 11 pages, 7 figures, accepted for publication in A&

Using Neural Networks for Relation Extraction from Biomedical Literature

Using different sources of information to support automated extracting of relations between biomedical concepts contributes to the development of our understanding of biological systems. The primary comprehensive source of these relations is biomedical literature. Several relation extraction approaches have been proposed to identify relations between concepts in biomedical literature, namely, using neural networks algorithms. The use of multichannel architectures composed of multiple data representations, as in deep neural networks, is leading to state-of-the-art results. The right combination of data representations can eventually lead us to even higher evaluation scores in relation extraction tasks. Thus, biomedical ontologies play a fundamental role by providing semantic and ancestry information about an entity. The incorporation of biomedical ontologies has already been proved to enhance previous state-of-the-art results.Comment: Artificial Neural Networks book (Springer) - Chapter 1