Burglary project

This report outlines the process and findings from an innovative project for students. This work was part of the curriculum and involved students working with West Yorkshire Police as part of the safer Leeds project in designing and making a film for students n crime prevention and personal safety in Leed

The Hoyle Family: break-up measurements to probe α-condensation in light nuclei

The 12C Hoyle state is a candidate for α-condensation, due to its large volume and αcluster structure. This paper discusses precision break-up measurements and how they can elucidate α-condensate structures. Two experiments are discussed in detail, firstly concerning the break-up of 12C and then the decays of heavier nuclei. With more theoretical input, and increasingly complex detector setups, precision break-up measurements can, in principle, provide insight into the structures of states in α-conjugate nuclei. At present, such searches have not delivered evidence for α-condensation in 12C or 16O

A combined study of heat and mass transfer in an infant incubator with an overhead screen

The main objective of this study is to investigate the major physical processes taking place inside an infant incubator, before and after modifications have been made to its interior chamber. The modification involves the addition of an overhead screen to decrease radiation heat losses from the infant placed inside the incubator. The present study investigates the effect of these modifications on the convective heat flux from the infant’s body to the surrounding environment inside the incubator. A combined analysis of airflow and heat transfer due to conduction, convection, radiation and evaporation has been performed, in order to calculate the temperature and velocity fields inside the incubator before and after the design modification. Due to the geometrical complexity of the model, Computer-Aided Design (CAD) applications were used to generate a computer-based model. All numerical calculations have been performed using the commercial Computational Fluid Dynamics (CFD) package FLUENT, together with in-house routines used for managing purposes and User-Defined Functions (UDFs) which extend the basic solver capabilities. Numerical calculations have been performed for three different air inlet temperatures: 32, 34 and 36ºC. The study shows a decrease of the radiative and convective heat losses when the overhead screen is present. The results obtained were numerically verified as well as compared with results available in the literature from investigations of dry heat losses from infant manikins

Girlguiding Medicine Maker Badge

This badge is a collaboration between Girlguiding Dundee and the Wellcome Centre for AntiInfectives Research (WCAIR). The Centre is part of the School of Life Sciences at the University of Dundee. The activities have been created by scientists who work on the development of new medicines to treat infectious diseases. We would like to thank everyone who has been involved for all of their hard work

Clustering in 18O - absolute determination of branching ratios via high-resolution particle spectroscopy

The determination of absolute branching ratios for high-energy states in light nuclei is an important and useful tool for probing the underlying nuclear structure of individual resonances: for example, in establishing the tendency of an excited state towards α -cluster structure. Difficulty arises in measuring these branching ratios due to similarities in available decay channels, such as ( 18 O, n ) and ( 18 O, 2 n ), as well as differences in geometric efficiencies due to population of bound excited levels in daughter nuclei. Methods are presented using Monte Carlo techniques to overcome these issues

Theoretical approaches to the 3α break-up of 12C

Abstract Two recent experiments have indicated that the break-up of the 12C Hoyle state is dominated by the sequential 8Be(g.s.) + α decay channel. The rare direct 3α decay was found to contribute with a branching ratio of less than 0.047% (95% C.L.). However, the ability of experimentalists to successfully disentangle these two competing decay channels relies on accurate theoretical predictions of how they each manifest in phase space distribution of the three break-up α-particles. The following paper reviews the current theoretical approaches to calculating the break-up of the Hoyle state and introduces a semi-classical WKB approach, which adequately reproduces the results of more sophisticated calculations. It is proposed that a more accurate upper limit on this branching ratio may be obtained if these new theoretical results are taken into account when analysing experimental data

Identification and characterization of an inhibitory fibroblast growth factor receptor 2 (FGFR2) molecule, up-regulated in an Apert Syndrome mouse model

AS (Apert syndrome) is a congenital disease composed of skeletal, visceral and neural abnormalities, caused by dominant-acting mutations in FGFR2 [FGF (fibroblast growth factor) receptor 2]. Multiple FGFR2 splice variants are generated through alternative splicing, including PTC (premature termination codon)-containing transcripts that are normally eliminated via the NMD (nonsense-mediated decay) pathway. We have discovered that a soluble truncated FGFR2 molecule encoded by a PTC-containing transcript is up-regulated and persists in tissues of an AS mouse model. We have termed this IIIa–TM as it arises from aberrant splicing of FGFR2 exon 7 (IIIa) into exon 10 [TM (transmembrane domain)]. IIIa–TM is glycosylated and can modulate the binding of FGF1 to FGFR2 molecules in BIAcore-binding assays. We also show that IIIa–TM can negatively regulate FGF signalling in vitro and in vivo. AS phenotypes are thought to result from gain-of-FGFR2 signalling, but our findings suggest that IIIa–TM can contribute to these through a loss-of-FGFR2 function mechanism. Moreover, our findings raise the interesting possibility that FGFR2 signalling may be a regulator of the NMD pathway

Structure of 10Be from the 12C 12C,14O 10Be reaction

The 12C 12C,14O two proton pick up reaction has been measured at 211.4 MeV incident energy to study the structure of states of 10Be up to excitation energies of 12 MeV. The measured partial angular distributions show pronounced oscillatory shapes, which were described by coupled reaction channels calculations. Spin parity assignments could be derived from these characteristic shapes and two definite assignments have been made. The state at 11.8 MeV has been identified as the 4 member of the ground state band, and the state at 10.55 MeV is assigned J pi 3 . At 5.96 MeV only the 1 1 member of the known 2 2 1 1 doublet is populated. The angular distribution of the peak at 9.50 MeV, which consists of several unresolved states, has been unfolded using contributions from known states at 9.56 MeV, 2 , and 9.27 MeV, 4 . The inclusion of a state at 9.4 MeV reported by Daito it et al. from the 10B t,3He 10Be reaction and tentatively assigned 3 improved the fit considerably. A K 2 band is formed with the 2 2 state as the band head and the 3 state as the second member. The structures of the K pi 0 1, 2 2, and 1 1 bands are discusse

5-Carboxylcytosine is localized to euchromatic regions in the nuclei of follicular cells in axolotl ovary

5-Methylcytosine (5-mC) is an epigenetic modification associated with gene repression. Recent studies demonstrated that 5-mC can be enzymatically oxidised into 5-hydroxymethylcytosine and further into 5-formylcytosine (5-fC) and 5-carboxylcytsine (5-caC). 5-caC has been found in embryonic stem cells and in mouse pre-implantation embryos but no detectable levels of this modification have been reported for somatic tissues to date. Whereas it has been suggested that 5-caC can serve as an intermediate in the process of active demethylation, the function of this form of modified cytosine remains obscure. Here we show that 5-caC is immunochemically detectable in somatic cells of axolotl ovary. We demonstrate that both 5-hmC and 5-caC are localized to the euchromatin in the nuclei of axolotl follicular cells with similar patterns of spatial distribution. Our results suggest that 5-carboxylcytosine may play a distinct functional role in certain biological contexts

New Measurement of the Direct 3α Decay from the 12C Hoyle State

Excited states in certain atomic nuclei possess an unusual structure, where the dominant degrees of freedom are those of α clusters rather than individual nucleons. It has been proposed that the diffuse 3α system of the 12C Hoyle state may behave like a Bose-Einstein condensate, where the α clusters maintain their bosonic identities. By measuring the decay of the Hoyle state into three α particles, we obtained an upper limit for the rare direct 3α decay branch of 0.047%. This value is now at a level comparable with theoretical predictions and could be a sensitive probe of the structure of this state