The evaluation of a self-enumerated scale of quality of life (CASP-19) in the context of research on ageing : a combination of exploratory and confirmatory approaches

This paper describes the conceptual development of a self-enumerated scale of quality of life (CASP-19) and presents an empirical evaluation of its structure using a combination of exploratory and confirmatory factor analytic approaches across three different survey settings for older people living in England and Wales in the new millennium. All evaluations are conducted using MPlus which allows the analyst to evaluate the properties of the scale for a set of multivariate categorical items which are subject to item non-response. CASP-19 is a subjective measure of well-being derived from an explicit theory of human need spanning four life domains: control, autonomy, self-realisation and pleasure. Put formally, CASP-19 is a self-reported summative index consisting of 19 Likert scale items. The three survey settings include a postal survey of 263 people in early old age followed up from childhood when the respondents were first interviewed in the 1930's, the first wave (2002) of the English Longitudinal Study of Ageing (ELSA_1) and the eleventh wave of the British Household Panel Survey (BHPS_11) also conducted in 2002. These nationally representative surveys consisted of 9300 and 6471 respondents aged 55 years and older. The Boyd-Orr sample provides an exploratory context for the evaluation and ELSA_1 together with BHPS_11 provide the opportunity for confirmatory analyses of three measurement models. There is some support for the use of CASP-19 as a stand alone summative index. However, the analysis reveals that a shortened 12-item scale which combines the life domains 'control and autonomy' in a second order measurement model is the recommended model for analysts. The work was funded under the UK's Economic and Social Research Council's Growing Older Programme and their Priority Network on Human Capability and Resilience. Grant Nos. L480254016 & L326253061. © Springer Science+Business Media B.V. 2007

Must naive realists be relationalists?

Relationalism maintains that perceptual experience involves, as part of its nature, a distinctive kind of conscious perceptual relation between a subject of experience and an object of experience. Together with the claim that perceptual experience is presentational, relationalism is widely believed to be a core aspect of the naive realist outlook on perception. This is a mistake. I argue that naive realism about perception can be upheld without a commitment to relationalism

Methodology for reliable and reproducible cryopreservation of human cervical tissue

BACKGROUND: In order to conduct laboratory studies on donated cervical tissue at suitable times an effective and reliable cryopreservation protocol for cervical tissue is required. METHODS: An active freezing approach was devised utilising 10% dimethyl sulfoxide in foetal bovine serum as a cryoprotective agent with a cooling rate of 1 °C/min to -50 °C then 10 °C/min to -120 °C; a related thawing protocol was also optimised which would allow for the bio-banking of cervical tissue. Viability of freshly harvested cervical tissue was compared to frozen-thawed samples utilising colorimetric MTT assay. In parallel, fresh and freeze-thawed samples were cultured and tested on days 1, 7 and 14 to determine whether bio-banking had detrimental effects on tissue viability over time. RESULTS: Repeat testing revealed that tissue viability between fresh and freeze-thawed wasand freeze-thawed samples was comparable at all four time points (days 0, 1, 7 and 14) with no apparent reductions of viability, thus demonstrating this method of cryopreserving cervical tissue is reliable and reproducible, without detrimental effects on live tissue culture. We believe this methodology creates the opportunity for bio-banking donated cervical tissues, which aids improved experimental design and reduces time pressures and wastage

Middle-out reasoning for synthesis and induction

We develop two applications of middle-out reasoning in inductive proofs: Logic program synthesis and the selection of induction schemes. Middle-out reasoning as part of proof planning was first suggested by Bundy et al [Bundy et al 90a]. Middle-out reasoning uses variables to represent unknown terms and formulae. Unification instantiates the variables in the subsequent planning, while proof planning provides the necessary search control. Middle-out reasoning is used for synthesis by planning the verification of an unknown logic program: The program body is represented with a meta-variable. The planning results both in an instantiation of the program body and a plan for the verification of that program. If the plan executes successfully, the synthesized program is partially correct and complete. Middle-out reasoning is also used to select induction schemes. Finding an appropriate induction scheme during synthesis is difficult, because the recursion of the program, which is un..

Extending Color Psychology to the Personality Realm: Interpersonal Hostility Varies by Red Preferences and Perceptual Biases

The color psychology literature has made a convincing case that color is not just about aesthetics, but also about meaning. This work has involved situational manipulations of color, rendering it uncertain as to whether color-meaning associations can be used to characterize how people differ from each other. The present research focuses on the idea that the color red is linked to, or associated with, individual differences in interpersonal hostility. Across four studies (N = 376 undergraduates), red preferences and perceptual biases were measured along with individual differences in interpersonal hostility. It was found that (a) a preference for the color red was higher as interpersonal hostility increased, (b) hostile people were biased to see the color red more frequently than nonhostile people, and (c) there was a relationship between a preference for the color red and hostile social decision making. These studies represent an important extension of the color psychology literature, highlighting the need to attend to person-based, as well as situation-based, factors

Anxiety and burnout in young athletes: The mediating role of cognitive appraisal

This study tested the relationship between trait anxiety, cognitive appraisal, and athletes’ burnout proposing two hypotheses: (a) there is a direct relationship between athletes’ trait anxiety and cognitive appraisal and burnout; and (b) cognitive appraisal mediates the relationship between trait anxiety and burnout and this mediation occurs despite the competitive level and sport records of athletes. The study included 673 young athletes and provided measures of trait anxiety, cognitive appraisal, and burnout. Structural equation modelling indicated that cognitive appraisal mediates the relationship between trait anxiety and burnout, confirming hypothesis 2, and this model provided better fit than the direct model of hypothesis 1. However, the mediation also indicated that the direct relationship between trait anxiety and burnout should be considered. The mediating model was invariant according to competitive levels and sport records. In conclusion, cognitive appraisal is an important variable in explaining athletes’ burnout.This study was conducted at Psychology Research Centre (UID/PSI/01662/2013), University of Minho, and supported by the Portuguese Foundation for Science and Technology, the Portuguese Ministry of Science, Technology and Higher Education through national funds and co-financed by FEDER through COMPETE2020 under the PT2020 Partnership Agreement (POCI-01-0145-FEDER-007653), and "Guimaraes, European City of Sport 2013".info:eu-repo/semantics/publishedVersio

Electrochemical mapping reveals direct correlation between heterogeneous electron-transfer kinetics and local density of states in diamond electrodes

Conducting carbon materials: A multi-microscopy approach shows that local heterogeneous electron-transfer rates at conducting diamond electrodes correlate with the local density of electronic states. This model of electroactivity is of considerable value for the rational design of conducting diamond electrochemical technologies, and also provides key general insights on electrode structure controls in electrochemical kinetic

Resting state cortico-cerebellar functional connectivity networks: a comparison of anatomical and self-organizing map approaches.

The cerebellum plays a role in a wide variety of complex behaviors. In order to better understand the role of the cerebellum in human behavior, it is important to know how this structure interacts with cortical and other subcortical regions of the brain. To date, several studies have investigated the cerebellum using resting-state functional connectivity magnetic resonance imaging (fcMRI; Krienen and Buckner, 2009; O'Reilly et al., 2010; Buckner et al., 2011). However, none of this work has taken an anatomically-driven lobular approach. Furthermore, though detailed maps of cerebral cortex and cerebellum networks have been proposed using different network solutions based on the cerebral cortex (Buckner et al., 2011), it remains unknown whether or not an anatomical lobular breakdown best encompasses the networks of the cerebellum. Here, we used fcMRI to create an anatomically-driven connectivity atlas of the cerebellar lobules. Timecourses were extracted from the lobules of the right hemisphere and vermis. We found distinct networks for the individual lobules with a clear division into "motor" and "non-motor" regions. We also used a self-organizing map (SOM) algorithm to parcellate the cerebellum. This allowed us to investigate redundancy and independence of the anatomically identified cerebellar networks. We found that while anatomical boundaries in the anterior cerebellum provide functional subdivisions of a larger motor grouping defined using our SOM algorithm, in the posterior cerebellum, the lobules were made up of sub-regions associated with distinct functional networks. Together, our results indicate that the lobular boundaries of the human cerebellum are not necessarily indicative of functional boundaries, though anatomical divisions can be useful. Additionally, driving the analyses from the cerebellum is key to determining the complete picture of functional connectivity within the structure