Mu-opioid receptor activation in the medial shell of nucleus accumbens promotes alcohol consumption, self-administration and cue-induced reinstatement

Endogenous opioid signaling in ventral cortico-striatal-pallidal circuitry is implicated in elevated alcohol consumption and relapse to alcohol seeking. Mu-opioid receptor activation in the medial shell of the nucleus accumbens (NAc), a region implicated in multiple aspects of reward processing, elevates alcohol consumption while NAc opioid antagonists reduce it. However, the precise nature of the increases in alcohol consumption, and the effects of mu-opioid agonists on alcohol seeking and relapse are not clear. Here, we tested the effects of the mu-opioid agonist [D-Ala(2), N-MePhe(4), Gly-ol]-enkephalin (DAMGO) in rat NAc shell on lick microstructure in a free-drinking test, alcohol seeking during operant self-administration, extinction learning and expression, and cue-reinforced reinstatement of alcohol seeking. DAMGO enhanced the number, but not the size of drinking bouts. DAMGO also enhanced operant alcohol self-administration and cue-induced reinstatement, but did not affect extinction learning or elicit reinstatement in the absence of cues. Our results suggest that mu-opioid agonism in NAc shell elevates alcohol consumption, seeking and conditioned reinforcement primarily by enhancing the incentive motivational properties of alcohol and alcohol-paired cues, rather than by modulating palatability, satiety, or reinforcement

Benny Goodman : airs du film / Steve ALLEN (dans le rôle de Goodman) et son orch.

Titre uniforme : [Sometimes I'm happy]Titre uniforme : [Stompin' at the Savoy]Titre uniforme : [Don't be that way]Titre uniforme : [King Porter stomp]Titre uniforme : [Don't be that way]Titre uniforme : [One o'clock jump]Comprend : LET'S DANCE / STONE - SOMETIMES I'M HAPPY / YOUMANS - MEMORIES OF YOU / BLAKE - STOMPIN'AT THE SAVOY / B. GOODMAN, WEEB - DON'T BE THAT WAY / MORTON - SING SING SING / PRIMA - MOONGLOW / HUDSON - ONE O'CLOCK JUMP / BASIE - AND THE ANGELS SING / MERCER, ELMAN - GOODBYE / JENKINSBnF-Partenariats, Collection sonore - BelieveContient une table des matière

THE HOME OF HAPPY FEET / Van Alexander and his Orchestra

Titre uniforme : [Stompin' at the Savoy]Titre uniforme : [Undecided]Titre uniforme : [Undecided]Titre uniforme : [Chant of the weed]Titre uniforme : [Christopher Columbus]Titre uniforme : [East Saint-Louis toodle-o]Titre uniforme : [East Saint-Louis toodle-o]Titre uniforme : [Christopher Colombus]Comprend : LET'S GET TOGETHER / Chick Webb - CHANT OF THE WEED / Donald Redman - UNTIL THE REAL THINGS COMES ALONG / Holiner ; Chaplin ; Nichols ; Cahn et Freeman - UPTOWN RHAPSODY / Teddy Hill et Léon Berry - STOMPIN' AT THE SAVOY / Goodman ; Webb et Sampson - UNDECIDED / Charles Shavers et Sid Robin - I WOULD DO ANYTHING FOR YOU / Hill ; Williams et Hopkins - A-TISKET A-TASKET / Ella Fitzgerald et Van Alexander - EAST ST LOUIS TOODLE-O / Duke Ellington et Bob Miley - ORGAN GRINDER'S SWING / Hudson ; Parish et Mills - CHRISTOPHER COLUMBUS / Léon Berry et Andy Razaf - RIDE, RED, RIDE / Lucky Millinder et Irving MillsBnF-Partenariats, Collection sonore - BelieveContient une table des matière

THE BENNY GOODMAN STORY : film Extraits / Benny Goodman et son Orchestre

Titre uniforme : [China boy]Titre uniforme : [Stompin' at the Savoy]Titre uniforme : [Bugle call rag]Titre uniforme : [Don't be that way]Titre uniforme : [Memories of you]Titre uniforme : [Bugle call rag]Titre uniforme : [Don't be that way]Titre uniforme : [Moonglow]Titre uniforme : [Bugle call rag]Titre uniforme : [Shine]Titre uniforme : [Avalon]Titre uniforme : [Down south camp meeting]Titre uniforme : [Don't be that way]Titre uniforme : [One o'clock jump]Comprend : LET'S DANCE / Stone ; Bonime et Baldridge - BUGLE CALL RAG / Schoebel ; Meyers et Pettis - MEMORIES OF YOU / Eubie Blake et Andy Razaf - ONE O'CLOCK JUMP / Count Basie - AVALON / Rose ; Jolson et de Sylva - DON'T BE THAT WAY / Goodman ; Sampson et Parish - DOWN SOUTH CAMP MEETIN' / Irving Mills et Fletcher Henderson - STOMPIN' AT THE SAVOY / Goodman ; Webb et Sampson - SING, SING, SING / Louis Prima - AND THE ANGELS SING / Ziggy Elman et Johnny Mercer - CHINA BOY / Phil Boutelje et Dick Winfree - IT'S BEEN SO LONG / Walter Donaldson et Harold Adamson - MOONGLOW / Hudson ; De Lange et Mills - SHINE / Dabney ; Mack et Brown - GOOD-BYE / Gordon JenkinsBnF-Partenariats, Collection sonore - BelieveContient une table des matière