Three-dimensional relationship between high-order root-mean-square wavefront error, pupil diameter, and aging

We report root-mean-square (RMS) wavefront error (WFE) for individual aberrations and cumulative highorder (HO) RMS WFE for the normal human eye as a function of age by decade and pupil diameter in 1 mm steps from 3 to 7 mm and determine the relationship among HO RMS WFE, mean age for each decade of life, and luminance for physiologic pupil diameters. Subjects included 146 healthy individuals from 20 to 80 years of age. Ocular aberration was measured on the preferred eye of each subject (for a total of 146 eyes through dilated pupils; computed for 3, 4, 5, 6, and 7 mm pupils; and described with a tenth-radial-order normalized Zernike expansion. We found that HO RMS WFE increases faster with increasing pupil diameter for any given age and pupil diameter than it does with increasing age alone. A planar function accounts for 99% of the variance in the 3-D space defined by mean log HO RMS WFE, mean age for each decade of life, and pupil diameter. When physiologic pupil diameters are used to estimate HO RMS WFE as a function of luminance and age, at low luminance 9 cd/m2 HO RMS WFE decreases with increasing age. This normative data set details (1) the 3-D relationship between HO RMS WFE and age for fixed pupil diameters and (2) the 3-D relationship among HO RMS WFE, age, and luminance for physiologic pupil diameters

Crotalus atrox venom preconditioning increases plasma fibrinogen and reduces perioperative hemorrhage in a rat model of surgical brain injury.

Perioperative bleeding is a potentially devastating complication in neurosurgical patients, and plasma fibrinogen concentration has been identified as a potential modifiable risk factor for perioperative bleeding. The aim of this study was to evaluate preconditioning with Crotalus atrox venom (Cv-PC) as potential preventive therapy for reducing perioperative hemorrhage in the rodent model of surgical brain injury (SBI). C. atrox venom contains snake venom metalloproteinases that cleave fibrinogen into fibrin split products without inducing clotting. Separately, fibrinogen split products induce fibrinogen production, thereby elevating plasma fibrinogen levels. Thus, the hypothesis was that preconditioning with C. atrox venom will produce fibrinogen spilt products, thereby upregulating fibrinogen levels, ultimately improving perioperative hemostasis during SBI. We observed that Cv-PC SBI animals had significantly reduced intraoperative hemorrhage and postoperative hematoma volumes compared to those of vehicle preconditioned SBI animals. Cv-PC animals were also found to have higher levels of plasma fibrinogen at the time of surgery, with unchanged prothrombin time. Cv-PC studies with fractions of C. atrox venom suggest that snake venom metalloproteinases are largely responsible for the improved hemostasis by Cv-PC. Our findings indicate that Cv-PC increases plasma fibrinogen levels and may provide a promising therapy for reducing perioperative hemorrhage in elective surgeries

The Building Blocks of Interoperability. A Multisite Analysis of Patient Demographic Attributes Available for Matching.

BackgroundPatient matching is a key barrier to achieving interoperability. Patient demographic elements must be consistently collected over time and region to be valuable elements for patient matching.ObjectivesWe sought to determine what patient demographic attributes are collected at multiple institutions in the United States and see how their availability changes over time and across clinical sites.MethodsWe compiled a list of 36 demographic elements that stakeholders previously identified as essential patient demographic attributes that should be collected for the purpose of linking patient records. We studied a convenience sample of 9 health care systems from geographically distinct sites around the country. We identified changes in the availability of individual patient demographic attributes over time and across clinical sites.ResultsSeveral attributes were consistently available over the study period (2005-2014) including last name (99.96%), first name (99.95%), date of birth (98.82%), gender/sex (99.73%), postal code (94.71%), and full street address (94.65%). Other attributes changed significantly from 2005-2014: Social security number (SSN) availability declined from 83.3% to 50.44% (p<0.0001). Email address availability increased from 8.94% up to 54% availability (p<0.0001). Work phone number increased from 20.61% to 52.33% (p<0.0001).ConclusionsOverall, first name, last name, date of birth, gender/sex and address were widely collected across institutional sites and over time. Availability of emerging attributes such as email and phone numbers are increasing while SSN use is declining. Understanding the relative availability of patient attributes can inform strategies for optimal matching in healthcare

Association of Accelerometry-Measured Physical Activity and Cardiovascular Events in Mobility-Limited Older Adults: The LIFE (Lifestyle Interventions and Independence for Elders) Study.

BACKGROUND:Data are sparse regarding the value of physical activity (PA) surveillance among older adults-particularly among those with mobility limitations. The objective of this study was to examine longitudinal associations between objectively measured daily PA and the incidence of cardiovascular events among older adults in the LIFE (Lifestyle Interventions and Independence for Elders) study. METHODS AND RESULTS:Cardiovascular events were adjudicated based on medical records review, and cardiovascular risk factors were controlled for in the analysis. Home-based activity data were collected by hip-worn accelerometers at baseline and at 6, 12, and 24 months postrandomization to either a physical activity or health education intervention. LIFE study participants (n=1590; age 78.9±5.2 [SD] years; 67.2% women) at baseline had an 11% lower incidence of experiencing a subsequent cardiovascular event per 500 steps taken per day based on activity data (hazard ratio, 0.89; 95% confidence interval, 0.84-0.96; P=0.001). At baseline, every 30 minutes spent performing activities ≥500 counts per minute (hazard ratio, 0.75; confidence interval, 0.65-0.89 [P=0.001]) were also associated with a lower incidence of cardiovascular events. Throughout follow-up (6, 12, and 24 months), both the number of steps per day (per 500 steps; hazard ratio, 0.90, confidence interval, 0.85-0.96 [P=0.001]) and duration of activity ≥500 counts per minute (per 30 minutes; hazard ratio, 0.76; confidence interval, 0.63-0.90 [P=0.002]) were significantly associated with lower cardiovascular event rates. CONCLUSIONS:Objective measurements of physical activity via accelerometry were associated with cardiovascular events among older adults with limited mobility (summary score >10 on the Short Physical Performance Battery) both using baseline and longitudinal data. CLINICAL TRIAL REGISTRATION:URL: http://www.clinicaltrials.gov. Unique identifier: NCT01072500

MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C

Cirrhosis likely shares common pathophysiological pathways despite arising from a variety of liver diseases. A recent GWAS identified rs641738, a polymorphism in the MBOAT7 locus, as being associated with the development of alcoholic cirrhosis. Here we explore the role of this variant on liver inflammation and fibrosis in two cohorts of patients with chronic hepatitis C. In 2,051 patients, rs641738 associated with severe hepatic inflammation and increased risk of fibrosis, as well as fast fibrosis progression. At functional level, rs641738 associated with MBOAT7 transcript and protein levels in liver and blood, and with serum inflammatory, oxidative stress and macrophage activation markers. MBOAT7 was expressed in immune cell subsets, implying a role in hepatic inflammation. We conclude that the MBOAT7 rs641738 polymorphism is a novel risk variant for liver inflammation in hepatitis C, and thereby for liver fibrosis

Reply to: Say What?! Ableist Logic Used in Misguided Attempt to Combat Ageism During COVID‐19

This letter comments on the letter by Bonnie Lashewicz

Systematic Analysis of Whole Exome Sequencing Determines RET G691S Polymorphism as Germline Variant in Melanoma

Abstract The RET proto-oncogene encodes a receptor tyrosine kinase that is activated by glial cell derived neutrotrophic factor (GDNF). Previous studies have found that a single nucleotide polymorphism (SNP), RETp (G691S), in the juxtamembrane domain enhances the signaling pathway and promotes tumor growth by GDNF in pancreatic and thyroid cancer in addition to melanoma. It is uncertain however whether this SNP is a germline variant or somatic mutation. A prior study reported that the RETp variant was a germline SNP in desmoplastic and non-desmoplastic melanomas. In the present study, we examined both melanoma tissue samples and matching peripheral blood DNA to determine if RETp was 1) a germline or somatic variant, 2) more frequent in certain melanoma subtypes, and 3) frequency in brain metastasis. We examined the peripheral blood of 197 melanoma patients whom had at least one matched tumor, and 42 patients with brain metastasis. RETp was present as a germline SNP in 33% of patients. There were no significant differences in RETp frequency among the different melanoma subtypes, and RETp was not correlated with brain metastasis

On Divestment

Foreword to On Divestment The writings collected here are an online supplement to a class zine title On Divestment. The zine and online archive were conceived, written, and designed by the members of the Spring 2015 Literature and Environment course (ENGL 374) at the University of Puget Sound. Considerations of timeliness and sustainability encouraged us to keep the size of the printed zine compact by including only excerpts of each author’s work; the zine is in a sense an advertisement for the more substantial body of writing that you find here on Sound Ideas, which reproduces student creative work in its entirety. Informed by our study of works of ecocriticism such as Rob Nixon’s Slow Violence and the Environmentalism of the Poor (Harvard UP, 2011), which explores the role that imaginative writing can play in illuminating ecological issues, our class seized the opportunity of a collaborative final project to see how students’ own writing—whether creative, critical, or some combination of the two—might engage with a topical environmental concern. The selection of a final project was arrived at through a democratic process. Working in groups of five individuals, students presented proposals for a final project, arguing both for the primacy of the environmental concern they selected and the efficacy of the writing task they were asking the class to undertake. All the proposals were excellent, but the class had to settle on a single undertaking; the project that students ultimately selected was the fossil fuel divestment movement, currently a topic of debate on many university campuses, including the University of Puget Sound. Largely led by students, this ongoing environmental movement encourages colleges and universities to divest their endowment holdings from companies whose primary business is fossil fuel. Since we knew from recent reportage in The Trail that UPS’s own ECO Club is advocating for fossil fuel divestment, we invited ECO Club representatives to speak to the class. From their visit, we learned about the broad contours of the divestment movement. Observing that the majority of scientists understand anthropogenic climate change to be the result of burning fossil fuels, the divestment movement argues that colleges and universities should exert pressure on these companies by withdrawing their investments from them. Several universities have already made commitments to divest some component of their endowment, among them Stanford University, Pitzer College, and the University of Glasgow, and campaigns to do so are underway at other institutions of higher learning, as well as many cities and municipalities. In formalizing the class proposal into an assignment, the terms were intentionally crafted to remain open-ended and non-prescriptive. Students were invited simply “to create a work of literature or literary analysis that engages with the issue of university fossil fuel divestment.” (Students could also opt out of the zine and write a more conventional final essay). Here are some excerpts from an email that I sent to the class elaborating on this non-traditional assignment. There\u27s a quotation by W.B. Yeats that strikes me as relevant here: Out of the quarrel with others we make rhetoric; out of the quarrel with ourselves we make poetry. What I understand Yeats to mean is that honest creative writing explores its subject, rather than argues a pre-established position. (For his word poetry in that quotation, you could equally substitute drama, or fiction, creative nonfiction, etc.) Our goal is to write literature, not propaganda . . . . While the work you create should shed light on some aspect of the divestment issue, it needn\u27t do so directly. In fact, it’s possible to shed light on the issue without even mentioning the word “divestment.” Consider, for example, the first novel we read this semester, Margaret Atwood’s Oryx and Crake. That novel engages with a host of environmental topics, among them global climate change, genetic engineering, population growth, the treatment of animals, and environmental justice. It doesn\u27t tell the reader what to do or think about any of these issues; rather, it explores them imaginatively, but it does so in a way that I believe encourages readers to be more reflective about each of those issues than they were before starting the novel. It sheds light on these issues. [K]eep in mind that this assignment does not expect that you will take a particular position. It does not assume that you will create a work of literature or literary criticism that is “for” fossil fuel divestment. (I\u27m not even sure that a work of art can ever be “for” or “against” a particular action. Is Oryx and Crake for or against the human manipulation of the environment? Who knows?—it\u27s a work of imaginative writing that tells a story. Readers can engage their own sense of values based upon the encounter with the imaginative work). I hope that this advice is helpful and that you feel authorized to write freely. I created the opportunity for the assignment because I believe that your voice—both individually and collectively—does matter and I wanted to facilitate a way for it to be heard, in however modest a fashion. What that voice says is entirely up to you. Those twenty voices from the class combine to form the collective voice you encounter here in the Sound Ideas archive On Divestment. On behalf of the writers and critics in ENGL 374, I invite you explore these remarkable poems, short stories, essays, and plays in their entirety. Best wishes, Prof. William Kupinse Department of Englis

Design, Qualification, and On Orbit Performance of the CALIPSO Aerosol Lidar Transmitter

The laser transmitter for the CALIPSO aerosol lidar mission has been operating on orbit as planned since June 2006. This document discusses the optical and laser system design and qualification process that led to this success. Space-qualifiable laser design guidelines included the use of mature laser technologies, the use of alignment sensitive resonator designs, the development and practice of stringent contamination control procedures, the operation of all optical components at appropriately derated levels, and the proper budgeting for the space-qualification of the electronics and software

Systematic Analysis of Whole Exome Sequencing Determines RET G691S Polymorphism as Germline Variant in Melanoma

The RET proto-oncogene encodes a receptor tyrosine kinase that is activated by glial cell derived neutrotrophic factor (GDNF). Previous studies have found that a single nucleotide polymorphism (SNP), RETp (G691S), in the juxtamembrane domain enhances the signaling pathway and promotes tumor growth by GDNF in pancreatic and thyroid cancer in addition to melanoma. It is uncertain however whether this SNP is a germline variant or somatic mutation. A prior study reported that the RETp variant was a germline SNP in desmoplastic and non-desmoplastic melanomas. In the present study, we examined both melanoma tissue samples and matching peripheral blood DNA to determine if RETp was 1) a germline or somatic variant, 2) more frequent in certain melanoma subtypes, and 3) frequency in brain metastasis. We examined the peripheral blood of 197 melanoma patients whom had at least one matched tumor, and 42 patients with brain metastasis. RETp was present as a germline SNP in 33% of patients. There were no significant differences in RETp frequency among the different melanoma subtypes, and RETp was not correlated with brain metastasis