1,485 research outputs found

    Is breeding in the city a walk in the park?: Researching the effects of "urbanness" and climate change in an iconic British bird

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    In the UK, urbanization continues unabated. We are fast losing 'greenspace', a key habitat for supporting many native species. Simultaneously, the impacts of climate change are also being observed, most notably in the increasing intensity and frequency of extreme weather events (EWEs). However, little is known about how wildlife respond to these multiple challenges. My research investigates how fine-scale environmental change within the complex cityscape affects the timing of breeding (phenology) and breeding success in the urban-adapted Blue Tit. Six years of nestbox data were collected from a network of 31 sites (N=310), covering a gradient of increasing urbanization and decreasing habitat connectivity in the city of Birmingham. I will introduce how I am modelling this data together with high resolution satellite and ground-based temperature and precipitation data, to better understand how the city environment buffers (or exacerbates) the potentially detrimental effects of extreme weather during different phases of the breeding cycle

    Evidence indicates that drug crime is greater in neighborhoods with middle and high schools.

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    For many adolescents experimenting with drugs is a fairly normal part of growing up, but many are accessing these drugs at, or near to, schools. In new research, Dale Willits, Lisa Broidy, and Kristine Denman find that drug crime is higher in city blocks that have middle and high schools. They write that schools give drug dealers and buyers the opportunity to meet, a process that occurs regardless of the neighborhood’s characteristics

    Natural Gas Development: Views of New York and Pennsylvania Residents in the Marcellus Shale Region

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    CaRDI Research & Policy Brief Issue 39; Community & Energy: Nonrenewable Energy Production and Developmen

    EXOGEN ultrasound bone healing system for long bone fractures with non-union or delayed healing: a NICE medical technology guidance

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    Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.This article has been made available through the Brunel Open Access Publishing Fund.A routine part of the process for developing National Institute for Health and Care Excellence (NICE) medical technologies guidance is a submission of clinical and economic evidence by the technology manufacturer. The Birmingham and Brunel Consortium External Assessment Centre (EAC; a consortium of the University of Birmingham and Brunel University) independently appraised the submission on the EXOGEN bone healing system for long bone fractures with non-union or delayed healing. This article is an overview of the original evidence submitted, the EAC’s findings, and the final NICE guidance issued.The Birmingham and Brunel Consortium is funded by NICE to act as an External Assessment Centre for the Medical Technologies Evaluation Programme

    Withdrawal from treatment as an outcome in the Isolde study of COPD

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    Objectives: To investigate the determinants of patient withdrawal from our study, and the effect of these withdrawals on the outcome of treatment with inhaled corticosteroids in patients with COPD. Design: A double-blind, placebo-controlled, randomized trial. Setting: Eighteen outpatient centers in the United Kingdom. Participants: Seven hundred fifty-one patients with stable COPD defined clinically as baseline postbronchodilator FEV1 > 0.8 L and < 85% predicted, FEV1/FVC ratio < 70%, and FEV1 change after albuterol < 10% of predicted. Intervention: Random assignment of either 500 micrograms bid of inhaled fluticasone propionate (FP)using a spacer device or an identical placebo inhaler. Treatment was continued for 3 years or until patients withdrew from follow-up. Measurements and results: Postbronchodilator FEV1 was measured on three occasions before randomization and every 3 months thereafter. Health status was assessed by the disease-specific St. George Respiratory Questionnaire (SGRQ) and the modified short-form 36 questionnaire (SF-36) at baseline and every 6 months. Three hundred thirty-nine patients withdrew, of whom 156 patients received FP. Prescription of frequent courses of oral prednisolone was the most common reason for withdrawing as specified in the protocol (69 patients in the FP group withdrew due to respiratory symptoms, compared with 93 patients in the placebo group). This explained the significantly greater dropout of placebo-treated patients that was most evident when FEV1 was < 50% predicted. Patients withdrawing had a significantly more rapid decline in health status, measured by both the SGRQ and the SF-36 (p < 0.001). Those withdrawing from the placebo group had a more rapid decline in FEV1 and more exacerbations than the FP-treated groups. Baseline FEV1 was lower in dropouts than in patients completing the study receiving placebo, but there was no difference between the respective groups receiving FP. Conclusions: Patients who withdrew from follow-up were those with the most rapidly deteriorating health status and lung function. Losing these patients from the final analysis can reduce the power of a study to achieve its primary end point
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