Index of articles 1960-2010

This subject index covers all articles published during the first 50 years of the Quarterly Bulletin (ie up to 2010 Q3). It also includes the main subjects of speeches by the Governors, senior staff and external MPC members, together with notices and notes, including ‘boxes’ in articles and in the various regular commentary articles. It does not include the subject matter of the commentary articles themselves, nor does it cover the statistical annex. Neither does it include the Inflation Report, which was contained within the Quarterly Bulletin during 1993.

The history of the Quarterly Bulletin

This edition marks the 50th anniversary of the Quarterly Bulletin. Over the years, the Bulletin has been one of the main conduits through which the Bank has communicated its thinking to the wider public. This article reviews the history of the Bulletin — both its origins and its subsequent evolution — as well as examining some of the insights that can be gleaned from its pages on some of the key central banking issues of the time.

Effects of human recombinant growth hormone on exercise capacity, cardiac structure, and cardiac function in patients with adult-onset growth hormone deficiency

Objective Epidemiological studies suggest that adult-onset growth hormone deficiency (AGHD) might increase the risk of death from cardiovascular causes. Methods This was a 6-month double-blind, placebo-controlled, randomised, cross-over trial followed by a 6-month open-label phase. Seventeen patients with AGHD received either recombinant human growth hormone (rGH) (0.4 mg injection daily) or placebo for 12 weeks, underwent washout for 2 weeks, and were then crossed over to the alternative treatment for a further 12 weeks. Cardiac magnetic resonance imaging, echocardiography, and cardiopulmonary exercise testing were performed at baseline, 12 weeks, 26 weeks, and the end of the open phase (12 months). The results were compared with those of 16 age- and sex-matched control subjects. Results At baseline, patients with AGHD had a significantly higher systolic blood pressure, ejection fraction, and left ventricular mass than the control group, even when corrected for body surface area. Treatment with rGH normalised the insulin-like growth factor 1 concentration without an effect on exercise capacity, cardiac structure, or cardiac function. Conclusion Administration of rGH therapy for 6 to 9 months failed to normalise the functional and structural cardiac differences observed in patients with AGHD when compared with a control group

MEME-LaB : motif analysis in clusters

Genome-wide expression analysis can result in large numbers of clusters of co-expressed genes. While there are tools for ab initio discovery of transcription factor binding sites, most do not provide a quick and easy way to study large numbers of clusters. To address this, we introduce a web-tool called MEME-LaB. The tool wraps MEME (an ab initio motif finder), providing an interface for users to input multiple gene clusters, retrieve promoter sequences, run motif finding, and then easily browse and condense the results, facilitating better interpretation of the results from large-scale datasets

A phylogenetic analysis of Orlando Gibbons's Prelude in G

This is the author accepted manuscript. The final version is available from Oxford University Press via http://dx.doi.org/10.1093/em/cau10

Living a Healthy Lifestyle

Powerpoint on many aspects of healthy that may be impacted during the first year transition of college.https://digitalcommons.cortland.edu/corslides/1015/thumbnail.jp

Making open data work for plant scientists

Despite the clear demand for open data sharing, its implementation within plant science is still limited. This is, at least in part, because open data-sharing raises several unanswered questions and challenges to current research practices. In this commentary, some of the challenges encountered by plant researchers at the bench when generating, interpreting, and attempting to disseminate their data have been highlighted. The difficulties involved in sharing sequencing, transcriptomics, proteomics, and metabolomics data are reviewed. The benefits and drawbacks of three data-sharing venues currently available to plant scientists are identified and assessed: (i) journal publication; (ii) university repositories; and (iii) community and project-specific databases. It is concluded that community and project-specific databases are the most useful to researchers interested in effective data sharing, since these databases are explicitly created to meet the researchers’ needs, support extensive curation, and embody a heightened awareness of what it takes to make data reuseable by others. Such bottom-up and community-driven approaches need to be valued by the research community, supported by publishers, and provided with long-term sustainable support by funding bodies and government. At the same time, these databases need to be linked to generic databases where possible, in order to be discoverable to the majority of researchers and thus promote effective and efficient data sharing. As we look forward to a future that embraces open access to data and publications, it is essential that data policies, data curation, data integration, data infrastructure, and data funding are linked together so as to foster data access and research productivity

A local regulatory network around three NAC transcription factors in stress responses and senescence in Arabidopsis leaves

A model is presented describing the gene regulatory network surrounding three similar NAC transcription factors that have roles in Arabidopsis leaf senescence and stress responses. ANAC019, ANAC055 and ANAC072 belong to the same clade of NAC domain genes and have overlapping expression patterns. A combination of promoter DNA/protein interactions identified using yeast 1-hybrid analysis and modelling using gene expression time course data has been applied to predict the regulatory network upstream of these genes. Similarities and divergence in regulation during a variety of stress responses are predicted by different combinations of upstream transcription factors binding and also by the modelling. Mutant analysis with potential upstream genes was used to test and confirm some of the predicted interactions. Gene expression analysis in mutants of ANAC019 and ANAC055 at different times during leaf senescence has revealed a distinctly different role for each of these genes. Yeast 1-hybrid analysis is shown to be a valuable tool that can distinguish clades of binding proteins and be used to test and quantify protein binding to predicted promoter motifs

Markets and operations: 2011 Q4

This article reviews developments in sterling financial markets, including the Bank’s official operations, between the 2011 Q3 Quarterly Bulletin and 25 November 2011. The article also summarises market intelligence on selected topical issues relating to market functioning.

Markets and operations: 2011 Q1

This article reviews developments in sterling financial markets, including the Bank’s official operations, between the 2010 Q4 Quarterly Bulletin and 25 February 2011. The article also summarises market intelligence on selected topical issues relating to market functioning.