Intensive care unit-related fluconazole use in Spain and Germany: patient characteristics and outcomes of a prospective multicenter longitudinal observational study

Background: Candida spp. are a frequent cause of nosocomial bloodstream infections worldwide. Objective: To evaluate the use patterns and outcomes associated with intravenous (IV) fluconazole therapy in intensive care units in Spain and Germany. Patients and methods: The research reported here was a prospective multicenter longitudinal observational study in adult intensive care unit patients receiving IV fluconazole. Demographic, microbiologic, therapy success, length of hospital stay, adverse event, and all-cause mortality data were collected at 14 sites in Spain and five in Germany, from February 2004 to November 2005. Results: Patients (n = 303) received prophylaxis (n = 29), empiric therapy (n = 140), preemptive therapy (n = 85), or definitive therapy (n = 49). A total of 298 patients (98.4%) were treated with IV fluconazole as first-line therapy. The treating physicians judged therapy successful in 66% of prophylactic, 55% of empiric, 45% of preemptive, and 43% of definitive group patients. In the subgroup of 152 patients with proven and specified Candida infection only, 32% suffered from Candida specified as potentially resistant to IV fluconazole. The overall mortality rate was 42%. Conclusion: Our study informs treatment decision makers that approximately 32% of the patients with microbiological results available suffered from Candida specified as potentially resistant to IV fluconazole, highlighting the importance of appropriate therapy

Brief Note: A Scanning Electron Microscopic Study of the Mouthparts of Cheumatopsyche Analis (Trichoptera; Hydropsychidae) Larvae

Author Institution: Department of Zoology, Miami Universit

Distribution, Abundance, and Age Structure of a Population of the Burrowing Mayfly, Hexagenia Limbata, in an Ohio Pond

Author Institution: Department of Zoology, Miami UniversityRUTTER, ROBERT P., AND THOMAS E. WISSING, Distribution, Abundance and Age Structure of a Population of the Burrowing Mayfly, Hexagenia limbata, in an Ohio Pond. Ohio J. Sci. 75(1): 7, 1975

Die Erwartungen der Industrie für das Jahr 2000 - Elektroindustrie: trotz deutlicher Belebung der Exporte nur verhaltener Optimismus

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Die Erwartungen der Industrie für 2002

Für das kommende Jahr rechnen die Konjunkturforscher mit einem weiterhin schwachen Wirtschaftswachstum. Die Zunahme des realen Bruttoinlandsproduktes dürfte 2002 in der Größenordnung von 0,7% liegen nach 0,6% in diesem Jahr. Wie schätzt die Industrie ihre Aussichten für 2002 ein? Welche Erwartungen hat sie an die Wirtschaftspolitik der Bundesregierung? --