Social marketing: Immunizing against unethical practice

A simple approach for the catalytic conversion of primary alcohols into their corresponding esters and amides, with evolution of H2 gas using in situ formed ruthenium PNP- and PNN-pincer catalysts, is presented. The evaluation showed conversions for the esterification with turnover numbers as high as 4300, and 4400 for the amidation

Thou: The connection between Shakespeare and his Sonnets

William Shakespeare Sonnet’s were written from an autobiographical point of view that represents his personal struggles with love and. Most notably defining this idea is the use of the word “thou”, that which indicates identity, ownership and things one is owned. Shakespeare uses the friendship with the young man to showcase his desires for love and an everlasting saga for the young man. The spirit of the relationship between the two was perfectly normal for the time period, and a very strong relationship as Shakespeare’s strong language suggests. A relationship that reaches its climax in Sonnet 18, “Shall I compare thee to a summer’s day…..” So was the end of Shakespeare’s struggle with love truly defined in the end of The Sonnets? The world will never know, but poetic art and love can both be present in an autobiographical work, one which truly encompasses the word “thou”. 

Learning To Do in Vivo Neural Responses in Mice

Timothy Mogan, Tyler Erker, Riley Faulhammer and Justin Wobser were the target students for this stereotaxic neurosurgery and electrophysiology lab experience. They are Pre-Nursing, Pre-Neuroscience (Pyschology) or Pre-Med majors. This richly educational and hands-on investigation significantly enhanced their confidence and experience in RODENT HANDLING, ANESTHESIA, ELECTROPHSYIOLOGY, PERFUSION, BRAIN REMOVAL and GENERAL LAB SKILLS. An animal use protocol was created for the project under the guidance of the Mentors and the students followed it competently. Students completed CITI online animal research training and animal handling training was provided by Lou Turchyn, DVM. Animals for the research were generously donated by Dr. Turchyn and other animal investigators at CSU so that this investigation did not require any additional research animals. A poster presentation of the first stages of the study covering background and significance, data collection methods and specimen preservation was academically instructive. Next, the molecular biology analysis of the specimens is expected to generate a proof of concept for methods necessary to conduct ongoing research in cochlear (inner ear) dysfunction ostensibly caused by dynorphins released during acoustic over-stimulation stress by Drs. Tony Sahley, David Anderson, Michael Hammonds and Karthik Chandu.https://engagedscholarship.csuohio.edu/u_poster_2018/1048/thumbnail.jp

Das Werk Alexander Kluges lesen/schauen/hören/spüren. Audiovisuelle Montagen als Movens eines ästhetischen Bildungsprojekts

Kluges Theorie und Medienpraxis ist bislang nur selten und dann bloß einseitig in bildungsphilosophischer und didaktischer Perspektive rezipiert worden. Diesem Desiderat widmet sich der folgende Beitrag, der Kluges Werk zunächst ausgehend von dessen Montageprinzip philosophisch zwischen Frankfurt und Frankreich verortet, um diese „Philosophie des Dazwischen“ anschließend mit Hilfe der aktuellen Modelle ästhetisch-performativer Bildungstheoretiker zu charakterisieren und didaktisch in die Schulpraxis zu überführen. Mittels Geschichte und Eigensinn und einem audiovisuellen Essay Kluges wird verdeutlicht, dass Kluges Werk ein innovatives multisensorisches „Lesenlernen“ ermöglichen kann.Jusqu’à présent, la théorie et la pratique médiatique d’Alexander Kluge n’ont que trop rarement – et alors de façon unilatérale – fait l’objet d’une approche relevant de la didactique et de la philosophie de l’éducation. Plaçant cette approche au centre de ses préoccupations et partant du principe klugien du montage, cet article entend d’abord situer philosophiquement l’œuvre de Kluge entre Francfort et la France. En un second temps et à l’aide de modèles issus des théories contemporaines de l’éducation esthético-performative, cette philosophie de « l’entre-deux » est définie et transposée dans la praxis scolaire. Partant de Histoire et obstination et d’un essai audiovisuel de Kluge, il s’agit de montrer que l’œuvre klugienne rend possible un apprentissage de la lecture qui est à la fois innovateur et multisensoriel.Kluge’s theory and media works have only rarely and merely one-sided been included and used in an educational and didactical perspective. This contribution aims at philosophically situating Kluge’s work and principle of montage between Frankfurt and France, in order to characterize subsequently this “philosophy of the in-between” with the help of current models of aesthetical-performative theorists of education, and to transfer it didactically into all-day school practice. Regarding History and Obstinacy and an audiovisual essay of Kluge, this article shows that Kluge’s work enables an innovative multisensory “learning-to-read”

Особенности фразеологического варианта в английском, немецком и шведском языках

Объект исследования – фразеология английского, немецкого и шведского языков, предмет изучения – характер вариантности ФЕ, цель исследования – выявление изоморфизма структурной организации германской фразеологии и вариантности посредством выполнения задач сопоставительного анализа, позволяющего выделить различные типы вариантов ФЕ в каждом из рассматриваемых германских языков

Evaluation eines retroviralen Transfektionssystems zur Hemmung der Telomerase mittels DN-hTERT in Neuroblastomzellen

Die Telomerase spielt eine Schlüsselrolle bei der Proliferation, bei Alterungsprozessen und der Krebsentstehung. Die klinische Anwendung der Telomeraseforschung zur Diagnose, Prognose und Therapieplanung verspricht insbesondere für das Neuroblastom eine Verbesserung der Behandlungsoptionen. Deshalb wurde in dieser Studie ein Transfektionssystem an Neuroblastomzelllinien entwickelt und evaluiert, welches eine Telomeraseinhibition mittels retroviralen Gentransfers einer dominant-negativen Mutante von hTERT bezweckt. Trotz erfolgreicher Genübertragung war in den verschiedenen Zelllinien nur eine inkonstante Expression von WT-hTERT und DN-hTERT nachweisbar. Dementsprechend fehlten funktionelle Konsequenzen einer Telomeraseinhibition wie Telomerenverkürzung, verändertes Wachstumsverhalten und Zelltod. Für eine effektive Telomerasehemmung bieten sich also in nachfolgenden Arbeiten alternative Vektorsysteme an, um neue Erkenntnisse über die Telomerenbiologie des Neuroblastoms zu gewinnen

Learning To Do in Vivo Neural Responses in Mice

Timothy Mogan, Tyler Erker, Riley Faulhammer and Justin Wobser were the target students for this stereotaxic neurosurgery and electrophysiology lab experience. They are Pre-Nursing, Pre-Neuroscience (Pyschology) or Pre-Med majors. This richly educational and hands-on investigation significantly enhanced their confidence and experience in RODENT HANDLING, ANESTHESIA, ELECTROPHSYIOLOGY, PERFUSION, BRAIN REMOVAL and GENERAL LAB SKILLS. An animal use protocol was created for the project under the guidance of the Mentors and the students followed it competently. Students completed CITI online animal research training and animal handling training was provided by Lou Turchyn, DVM. Animals for the research were generously donated by Dr. Turchyn and other animal investigators at CSU so that this investigation did not require any additional research animals. A poster presentation of the first stages of the study covering background and significance, data collection methods and specimen preservation was academically instructive. Next, the molecular biology analysis of the specimens is expected to generate a proof of concept for methods necessary to conduct ongoing research in cochlear (inner ear) dysfunction ostensibly caused by dynorphins released during acoustic over-stimulation stress by Drs. Tony Sahley, David Anderson, Michael Hammonds and Karthik Chandu.https://engagedscholarship.csuohio.edu/u_poster_2018/1048/thumbnail.jp

Genomische Amplifikationen und Koamplifikationen in ZNS-Tumoren

Die molekulare Grundlage der Entstehung solider ZNS-Tumoren ist nicht endgültig geklärt. Eine genomische Veränderung in der Tumorigenese liegt in der Amplifikation bestimmter DNA-Abschnitte. Für manche Tumoren stellt der Amplifikationsstatus spezifischer Gene einen prädiktiven Faktor bezüglich Tumorprogression und Therapieansprechen dar. Ziel der Arbeit war die Häufigkeit von Ko-/Amplifikationen auf 2p24 und 5p15 in soliden Hirntumoren zu untersuchen. Diese Genregionen beeinflussen Proliferation, Alterungsprozesse und neuronale Entwicklung. In 1/7 embryonalen Tumoren konnten signifikante Amplifikationen von MYCN sowie Koamplifikation von DDX1 und NAG quantifiziert werden. In 13/37 Tumoren fanden sich Amplifikationen auf 5p15.33. Erstmals wurden signifikante hTERT- und Irx1-Amplifikationen in Tumoren des ZNS nachgewiesen. Die pathogenetische Relevanz und prognostische Bedeutung dieser Genveränderungen bleibt Untersuchungen an einem größeren Kollektiv und auf Expressionsebene vorbehalten

The ketimide ligand is not just an inert spectator: heteroallene insertion reactivity of an actinide-ketimide linkage in a thorium carbene amide ketimide complex

The ketimide anion R2C[DOUBLE BOND]N− is an important class of chemically robust ligand that binds strongly to metal ions and is considered ideal for supporting reactive metal fragments due to its inert spectator nature; this contrasts with R2N− amides that exhibit a wide range of reactivities. Here, we report the synthesis and characterization of a rare example of an actinide ketimide complex [Th(BIPMTMS){N(SiMe3)2}(N[DOUBLE BOND]CPh2)] [2, BIPMTMS=C(PPh2NSiMe3)2]. Complex 2 contains Th[DOUBLE BOND]Ccarbene, Th[BOND]Namide and Th[BOND]Nketimide linkages, thereby presenting the opportunity to probe the preferential reactivity of these linkages. Importantly, reactivity studies of 2 with unsaturated substrates shows that insertion reactions occur preferentially at the Th[BOND]Nketimide bond rather than at the Th[DOUBLE BOND]Ccarbene or Th[BOND]Namide bonds. This overturns the established view that metal-ketimide linkages are purely inert spectators