Wordsworth & Basho—Walking Poets

‘Wordsworth and Basho: Walking Poets’ is a group exhibition based in the Wordsworth Trust, in Grasmere, UK. The exhibition builds on momentum developed through previous collaborations between the Wordsworth Trust, the University of Sunderland and Bath Spa University, in which a range of contemporary artists created fresh and challenging perspectives on Wordsworth’s poetry and Basho's work. Dr Manny Ling collaborated with the Japanese sumi painter Christine Flint Sato and produced a series of work that explored East Asian and western contexts. Dr Manny Ling also designed and curated the exhibition catalogue (ISBN: 978-1-906832-20-9

Susanna Blamire, Medicine, and Romantic Women's Poetry

This event took place on 28 April 2022 and was in collaboration with the University of Northumbria. Romantic poet Susanna Blamire (1747-1794) was a prolific Cumbria-based writer who explored topics including healthcare, religion and travel in both verse and prose. Little of her body of work was published during her lifetime. Over the last 25 years the Wordsworth Trust worked with Christopher Hugh Maycock, Blamire’s descendent and biographer (A Passionate Poet, Hypatia Press 2003; Selected Poems, Bookcase, 2008), to preserve her surviving manuscript works. Her writings not only reveal the hidden history of women’s medical work in the 18th century but form a starting point for exploring what good healthcare looks like in past, present and future. In this event our speakers took an in-depth look at Blamire’s life and writing, and showcased manuscripts and objects from the Wordsworth Trust’s collection. They explored topics including the experience of illness and disability in the late 18th century, how women influenced healthcare while being barred from medical school, and how creativity can interact with wellbeing. This event accompanied ‘(Re)Acting Romanticism: Disability and Women Writers’ at Wordsworth Grasmere, an exhibition that took place from April-May 2022. If you enjoyed this video, please consider making a donation to the Wordsworth Trust: https://wordsworth.org.uk/support

Budget impact and transferability of cost-effectiveness of DPYD testing in metastatic breast cancer in 3 health systems - supplementary material

Appendix Table 1. General (UK) model input parameter

Budget impact and transferability of cost-effectiveness of DPYD testing in metastatic breast cancer in 3 health systems - supplementary material

Appendix Table 1. General (UK) model input parameter

Investigating the viability of genetic screening/testing for RA susceptibility using combinations of five confirmed risk loci.

OBJECTIVE: Five loci-the shared epitope (SE) of HLA--DRB1, the PTPN22 gene, a locus on 6q23, the STAT4 gene and a locus mapping to the TRAF1/C5 genetic region--have now been unequivocally confirmed as conferring susceptibility to RA. The largest single effect is conferred by SE. We hypothesized that combinations of susceptibility alleles may increase risk over and above that of any individual locus alone. METHODS: We analysed data from 4238 RA cases and 1811 controls, for which genotypes were available at all five loci. RESULTS: Statistical analysis identified eight high-risk combinations conferring an odds ratio >6 compared with carriage of no susceptibility variants and, interestingly, 10% population controls carried a combination conferring high risk. All high-risk combinations included SE, and all but one contained PTPN22. Statistical modelling showed that a model containing only these two loci could achieve comparable sensitivity and specificity to a model including all five. Furthermore, replacing SE (which requires full subtyping at the HLA-DRB1 gene) with DRB1*1/4/10 carriage resulted in little further loss of information (correlation coefficient between models = 0.93). CONCLUSIONS: This represents the first exploration of the viability of population screening for RA and identifies several high-risk genetic combinations. However, given the population incidence of RA, genetic screening based on these loci alone is neither sufficiently sensitive nor specific at the current time

Exome-wide study of ankylosing spondylitis demonstrates additional shared genetic background with inflammatory bowel disease

Ankylosing spondylitis (AS) is a common chronic immune-mediated arthropathy affecting primarily the spine and pelvis. The condition is strongly associated with HLA-B*27 as well as other human leukocyte antigen variants and at least 47 individual non-MHC-associated variants. However, substantial additional heritability remains as yet unexplained. To identify further genetic variants associated with the disease, we undertook an association study of AS in 5,040 patients and 21,133 healthy controls using the Illumina Exomechip microarray. A novel association achieving genome-wide significance was noted at CDKAL1. Suggestive associations were demonstrated with common variants in FAM118A, C7orf72 and FAM114A1 and with a low-frequency variant in PNPLA1. Two of the variants have been previously associated with inflammatory bowel disease (IBD; CDKAL1 and C7orf72). These findings further increase the evidence for the marked similarity of genetic risk factors for IBD and AS, consistent with the two diseases having similar aetiopathogenesis