Evidence for ancient lithospheric deformation in the East European Craton based on mantle seismic anisotropy and crustal magnetics

International audienceWe present new shear-wave splitting measurements performed at 16 stations on the East European Craton, and discuss their implications in terms of upper-mantle anisotropy for this geophysically poorly-known region. Previous investigations of mantle anisotropy in Central Europe have shown fast directions aligning smoothly with the craton's margin and various suggestions have been proposed to explain their origin such as asthenospheric flow or lithospheric frozen-in deformation.;Here, we aim at investigating the continuation of this shear-wave splitting pattern further to the East, into the East European Craton For the craton, the interpretation appears to be less ambiguous than for central Europe since several arguments support lithospheric anisotropy in this region 1) The large-scale coherence within either of the four constituting blocks and the significant variations between the blocks on a small-scale, 2) the weak correlation with absolute plate motion vectors, and 3) the good correlation between anisotropy and crustal features, for which we use magnetic field alignments as a proxy. Rattler good correlation of these magnetic features with seismic fast orientations strongly supports the idea of vertically coherent deformation throughout upper mantle and crust. The observed splitting orientations thus reflect the last tectonic events of each block. frozen-in into the lithosphere for hundreds of millions of year

Identifying global seismic anisotropy patterns by correlating shear-wave splitting and surface-wave data

International audienceWe compare a global compilation of shear-wave splitting measurements with azimuthal seismic anisotropy parameters inferred from surface-wave tomography. The currently available splitting dataset is taken from a novel comprehensive collection of available publications that is updated interactively online. The comparison between the two types of data is made by calculating predicted splitting parameters from the anisotropic tomography model. Comparing these predicted splitting parameters with the observed ones, we find a considerable correlation between the two datasets at global scale. This result is noteworthy, since such correlation did not seem to exist in previous studies. The spatial resolution associated with the two types of methods is rather different. While surface waves have good vertical resolution and poor lateral resolution of several hundreds of kilometers, SKS splitting measurements have good lateral, but poor vertical resolution. The correlation can be understood in light of recent propositions that anisotropy seen by SKS splitting constrains mostly the upper mantle, and therefore a similar depth region as surface waves. The correlation also confirms the generally good quality of the shear-wave measurements, as well as that of the anisotropic tomography model

Classical Guitar Instruction for the Pre-College Classroom

This project is a curriculum for secondary guitar instruction. It consists of eight levels of study and is designed for the beginning to intermediate student. It has repertoire selections and explanations of the pedagogical validity of the works. These works were selected due to their cumulative and didactic nature and because of the specific technical issues they utilize. These technical issues are introduced gradually to ensure a student\u27s steady and incremental progress in both technical and musical aspects. The student executes exercises from such sources as Aaron Shearers: Learning the Classic Guitar, the Royal Conservatory of Music graded repertoire series, and works by many of the most celebrated composers for the instrument. This project includes repertoire of all styles and periods and is truly varied. It is an invaluable tool for any guitar educator

Ice fabric in an Antarctic ice stream interpreted from seismic anisotropy

Here we present new measurements of an anisotropic ice fabric in a fast moving (377 ma−1) ice stream in West Antarctica. We use ∼6000 measurements of shear wave splitting observed in microseismic signals from the bed of Rutford Ice Stream, to show that in contrast to large-scale ice flow models, which assume that ice is isotropic, the ice in Rutford Ice Stream is dominated by a previously unobserved type of partial girdle fabric. This fabric has a strong directional contrast in mechanical properties, shearing 9.1 times more easily along the ice flow direction than across flow. This observed fabric is likely to be widespread and representative of fabrics in other ice streams and large glaciers, suggesting it is essential to consider anisotropy in data-driven models to correctly predict ice loss and future flow in these regions. We show how passive microseismic monitoring can be effectively used to provide these data

Heritage branding orientation: The case of Ach. Brito and the dynamics between corporate and product heritage brands

The notion of heritage branding orientation is introduced and explicated. Heritage branding orientation is designated as embracing both product and corporate brands and differs from corporate heritage brand orientation which has an explicit corporate focus. Empirical insights are drawn from an in-depth and longitudinal case study of Ach. Brito, a celebrated Portuguese manufacturer of soaps and toiletries. This study shows how, by the pursuance of a strategy derived from a heritage branding orientation Ach. Brito – after a prolonged period of decline – achieved a dramatic strategic turnaround. The findings reveal how institutional heritage can be a strategic resource via its adoption and activation at both the product and corporate levels. Moreover, the study showed how the bi-lateral interplay between product and corporate brand levels can be mutually reinforcing. In instrumental terms, the study shows how heritage can be activated and articulated in different ways. For instance, it can re-position both product and/or corporate brands; it can be meaningfully informed by product brand heritage and shape corporate heritage; and can be of strategic importance to both medium-sized and small enterprises

Molecular Level in Silico Studies for Oncology. Direct Models Review

The combination of therapy and diagnostics in one process "theranostics" is a trend in a modern medicine, especially in oncology. Such an approach requires development and usage of multifunctional hybrid nanoparticles with a hierarchical structure. Numerical methods and mathematical models play a significant role in the design of the hierarchical nanoparticles and allow looking inside the nanoscale mechanisms of agent-cell interactions. The current position of in silico approach in biomedicine and oncology is discussed. The review of the molecular level in silico studies in oncology, which are using the direct models, is presented

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

Senescent cells secrete a combination of factors collectively known as the senescence-associated secretory phenotype (SASP). The SASP reinforces senescence and activates an immune surveillance response, but it can also show pro-tumorigenic properties and contribute to age-related pathologies. In a drug screen to find new SASP regulators, we uncovered the mTOR inhibitor rapamycin as a potent SASP suppressor. Here we report a mechanism by which mTOR controls the SASP by differentially regulating the translation of the MK2 (also known as MAPKAPK2) kinase through 4EBP1. In turn, MAPKAPK2 phosphorylates the RNA-binding protein ZFP36L1 during senescence, inhibiting its ability to degrade the transcripts of numerous SASP components. Consequently, mTOR inhibition or constitutive activation of ZFP36L1 impairs the non-cell-autonomous effects of senescent cells in both tumour-suppressive and tumour-promoting contexts. Altogether, our results place regulation of the SASP as a key mechanism by which mTOR could influence cancer, age-related diseases and immune responses

Role of tau versus TDP‐43 pathology on medial temporal lobe atrophy in aging and Alzheimer's disease

Hippocampal atrophy on magnetic resonance imaging is an important biomarker in Alzheimer's disease (AD). While hippocampal atrophy was thought to result from tau tangles in AD, different neuropathologies can lead to hippocampal atrophy, especially TAR DNA-binding protein 43 (TDP-43) pathology. In this narrative review, we evaluate existing studies on the relative contribution of tau and TDP-43 pathology to medial temporal lobe (MTL) atrophy. We report a clear association of both tau and TDP-43 neuropathology with MTL atrophy, even after correcting for other neuropathologies. Next, we discuss a potential synergism between tau and TDP-43 and the relative timing of the effects of both neuropathologies. Finally, avenues for future research will be discussed. A better understanding of the interplay between tau and TDP-43 neuropathologies and their effect on atrophy will help with the development of more specific biomarkers for limbic-predominant age-related TDP-43 encephalopathy and pinpointing of the optimal timing for testing anti-tau and anti-TDP-43 treatments in trials. HIGHLIGHTS: Both tau and TAR DNA-binding protein 43 (TDP-43) pathology contribute to medial temporal lobe atrophy. There is a positive association between tau and TDP-43 and potentially a synergism. It is unclear if tau and TDP-43 have an additive or synergistic effect on atrophy. The relative timing of the tau and TDP-43 effects on atrophy remains unclear. Clarifying the interplay between tau and TDP-43 will help improve magnetic resonance imaging biomarkers

Human cytomegalovirus immediate-early 1 protein rewires upstream STAT3 to downstream STAT1 signaling switching an IL6-type to an IFNγ-like response

MN and CP were supported by the Wellcome Trust (www.wellcome.ac.uk) Institutional Strategic Support Fund and CP was supported by the Deutsche Forschungsgemeinschaft (PA 815/2-1; www.dfg.de).The human cytomegalovirus (hCMV) major immediate-early 1 protein (IE1) is best known for activating transcription to facilitate viral replication. Here we present transcriptome data indicating that IE1 is as significant a repressor as it is an activator of host gene expression. Human cells induced to express IE1 exhibit global repression of IL6- and oncostatin M-responsive STAT3 target genes. This repression is followed by STAT1 phosphorylation and activation of STAT1 target genes normally induced by IFNγ. The observed repression and subsequent activation are both mediated through the same region (amino acids 410 to 445) in the C-terminal domain of IE1, and this region serves as a binding site for STAT3. Depletion of STAT3 phenocopies the STAT1-dependent IFNγ-like response to IE1. In contrast, depletion of the IL6 receptor (IL6ST) or the STAT kinase JAK1 prevents this response. Accordingly, treatment with IL6 leads to prolonged STAT1 instead of STAT3 activation in wild-type IE1 expressing cells, but not in cells expressing a mutant protein (IE1dl410-420) deficient for STAT3 binding. A very similar STAT1-directed response to IL6 is also present in cells infected with a wild-type or revertant hCMV, but not an IE1dl410-420 mutant virus, and this response results in restricted viral replication. We conclude that IE1 is sufficient and necessary to rewire upstream IL6-type to downstream IFNγ-like signaling, two pathways linked to opposing actions, resulting in repressed STAT3- and activated STAT1-responsive genes. These findings relate transcriptional repressor and activator functions of IE1 and suggest unexpected outcomes relevant to viral pathogenesis in response to cytokines or growth factors that signal through the IL6ST-JAK1-STAT3 axis in hCMV-infected cells. Our results also reveal that IE1, a protein considered to be a key activator of the hCMV productive cycle, has an unanticipated role in tempering viral replication.Publisher PDFPeer reviewe